Telmisartan And Hydrochlorothiazide Tablets

Sartel-H (Telmisartan 40 mg and Hydrochlorothiazide 12.5 mg Tablets) - Product Information

Sartel-H (Telmisartan 40 mg and Hydrochlorothiazide 12.5 mg Tablets) are combination of an angiotensin II receptor blocker (ARB) and a thiazide diuretic indicated for the treatment of hypertension, alone or with other antihypertensive agents, to lower blood pressure. Lowering blood pressure reduces the risk of fatal and nonfatal cardiovascular events, primarily strokes and myocardial infarctions.
Sartel-H tablets are manufactured by Intas Pharmaceuticals Limited, India in the strengths of 40 mg of Telmisartan and 12.5 mg of Hydrochlorothiazide.
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Name of the Drug

Sartel-H Tablets.

Manufacturer of Sartel-H Tablets

Intas Pharmaceuticals Limited, India.  
Website: www.intaspharma.com

Active Pharmaceutical Ingredient

The active ingredients present in Sartel-H tablets are Telmisartan and Hydrochlorothiazide. Each uncoated bilayered tablet of Sartel-H contains 40mg of Telmisartan and 12.5 mg of Hydrochlorothiazide.

Uses of Sartel-H (Telmisartan 40 mg and Hydrochlorothiazide 12.5 mg Tablets)

elmisartan and hydrochlorothiazide combination is used to treat high blood pressure (hypertension). High blood pressure adds to the workload of the heart and arteries. If it continues for a long time, the heart and arteries may not function properly. This can damage the blood vessels of the brain, heart, and kidneys, resulting in a stroke, heart failure, or kidney failure. A lower blood pressure can reduce the risk of strokes and heart attacks.

Sartel-H (Telmisartan and Hydrochlorothiazide Tablets) - Dosage

Generic Telmisartan and Hydrochlorothiazide tablets should be administered exactly as suggested by your doctor. Your doctor may recommend a dosage of Sartel-H tablets depending on your age, medical requirement, body weight, other medical conditions, and current medications.
The usual starting dose of telmisartan is 40 mg once a day; blood pressure response is dose related over the range of 20 to 80 mg. Patients with depletion of intravascular volume should have the condition corrected or telmisartan tablets should be initiated under close medical supervision. Patients with biliary obstructive disorders or hepatic insufficiency should have treatment started under close medical supervision.
Hydrochlorothiazide is effective in doses of 12.5 mg to 50 mg once daily.
To minimize dose-independent side effects, it is usually appropriate to begin combination therapy only after a patient has failed to achieve the desired effect with monotherapy. The side effects of Telmisartan are generally rare and apparently independent of dose; those of Hydrochlorothiazide are a mixture of dose-dependent phenomena (primarily hypokalemia) and dose-independent phenomena (e.g., pancreatitis), the former much more common than the latter.
Sartel-H tablets work effectively if the amount of Telmisartan and Hydrochlorothiazide is maintained at a constant level in the body. You should be systematic about the daily schedule for the medication such that you take tablets at about the same time every day, to get the maximum benefit of the medication. Continue taking tablets without missing any doses for the recommended treatment period and do not stop the treatment suddenly even if you feel better.

Please consult your doctor for exact dosing instructions.Sartel-H tablets (Generic Telmisartan and Hydrochlorothiazide tablets) should be administered in the dose prescribed by the doctor and for the duration recommended by the doctor.

Missed Dose

If you forget to take your regular Sartel-H tablet dose on time, take it whenever you remember.
If you remember the next day, skip the missed dose and take your scheduled dose. Do not take a double dose to compensate the missed dose.

Telmisartan and Hydrochlorothiazide Tablets Mechanism of Action

Telmisartan blocks receptors in your body that normally bind to a hormone called angiotensin II. When angiotensin II binds to these receptors, it causes your blood vessels to constrict. Blocking these receptors helps your blood vessels relax so that blood can move through them more easily.
Hydrochlorothiazide works by increasing how much you pee. It does this by helping the kidneys remove electrolytes, such as sodium (salt), and water from the body. It also appears to allow blood to flow more freely (less resistance to flow).
These effects can help lower blood pressure, and may reduce your risk for heart attack and stroke.

Storage Instructions for Sartel-H (Telmisartan and Hydrochlorothiazide Tablets)

Store at controlled room temperature (20°C to 25°C),protected from heat, moisture, and sunlight. Excursions are permitted from 15°C to 30°C.
Retain the original packing of the medication and do not consume past its expiration date printed on the blister pack. Keep the pack of away from the reach of children and pets. Do not dispose along with domestic waste or sewage. Consult your doctor or pharmacist about the correct method of disposal.

Contraindications

Sartel-H tablets are contraindicated in patients with a hypersensitivity to Telmisartan or Hydrochlorothiazide or any inactive ingredient present in tablets. Sartel-H are contraindicated in the following cases:

Sartel-H tablets are contraindicated in the following cases:
In patients with anuria.
Second and third trimesters of pregnancy, Biliary obstructive disorders and Severe hepatic impairment
Do not co-administer Aliskiren with Telmisartan tablets in patients with diabetes

Overdose

Telmisartan
Limited data are available with regard to overdosage of telmisartan in humans. The most likely manifestations of overdosage with telmisartan are hypotension, dizziness, and tachycardia; bradycardia could occur from parasympathetic (vagal) stimulation. If symptomatic hypotension should occur, supportive treatment should be instituted. Telmisartan is not removed by hemofiltration and is not dialyzable.
Hydrochlorothiazide
The most common signs and symptoms observed in patients with a hydrochlorothiazide overdose are those caused by electrolyte depletion (hypokalemia, hypochloremia, hyponatremia) and dehydration resulting from excessive diuresis. If digitalis has also been administered, hypokalemia may accentuate cardiac arrhythmias. The degree to which hydrochlorothiazide is removed by hemodialysis has not been established.

Warnings and Precautions

Fetal Toxicity:
Telmisartan:Use of drugs that act on the renin-angiotensin system during the second and third trimesters of pregnancy reduces fetal renal function and increases fetal and neonatal morbidity and death. Resulting oligohydramnios can be associated with fetal lung hypoplasia and skeletal deformations. Potential neonatal adverse effects include skull hypoplasia, anuria, hypotension, renal failure, and death.
Hydrochlorothiazide: Thiazides cross the placental barrier and appear in cord blood. Adverse reactions include fetal or neonatal jaundice and thrombocytopenia
Hypotension in Volume-or Salt-Depleted Patients
In patients with an activated renin-angiotensin system, such as volume-or salt-depleted patients (e.g., those being treated with high doses of diuretics), symptomatic hypotension may occur after initialization of treatment with telmisartan and hydrochlorothiazide tablets.
Impaired Renal Function
Changes in renal function including acute renal failure can be caused by drugs that inhibit the renin-angiotensin system and by diuretics. Patients whose renal function may depend in part on the activity of the renin-angiotensin system (e.g., patients with renal artery stenosis, chronic kidney disease, severe congestive heart failure, or volume depletion) may be at particular risk of developing oliguria, progressive azotemia, or acute renal failure on telmisartan and hydrochlorothiazide tablets.
Electrolytes and Metabolic Disorders
Drugs, including Telmisartan, that inhibit the renin-angiotensin system can cause hyperkalemia, particularly in patients with renal insufficiency, diabetes, or combination use with other angiotensin receptor blockers or ACE inhibitors and the concomitant use of other drugs that raise serum potassium levels
Hypersensitivity Reaction:
HydrochlorothiazideHypersensitivity reactions to hydrochlorothiazide may occur in patients with or without a history of allergy or bronchial asthma, but are more likely in patients with such a history
Acute Myopia and Secondary Angle-Closure Glaucoma

Hdrochlorothiazide, a sulfonamide, can cause an idiosyncratic reaction, resulting in acute transient myopia and acute angle-closure glaucoma. Symptoms include acute onset of decreased visual acuity or ocular pain and typically occur within hours to weeks of drug initiation. Untreated acute angle-closure glaucoma can lead to permanent vision loss. The primary treatment is to discontinue hydrochlorothiazide as rapidly as possible. Systemic Lupus Erythematosus
Thiazide diuretics have been reported to cause exacerbation or activation of systemic lupus erythematosus.
Postsympathectomy Patients
The antihypertensive effects of hydrochlorothiazide may be enhanced in the postsympathectomy patient.

Side Effects of Telmisartan and Hydrochlorothiazide Tablets

Side effects occurring with both Telmisartan and Hydrochlorothiazide include:
Common: Bronchitis, pharyngitis, sinusitis, upper respiratory tract infections, urinary tract infections, hypercholesterolemia, hypokalemia, anxiety, dizziness, vertigo, abdominal pain, diarrhea, dyspepsia, gastritis, eczema, arthralgia, osteoarthritis, back pain, muscle spasms or pain in extremity, m y a l g i a , erectile dysfunction, influenza-like illness, pain.
Uncommon: Hypersensitivity, diabetes mellitus inadequate control, hyperuricemia.
As with other angiotensin II antagonists isolated cases of angioneurotic oedema, urticaria and other related reactions have been reported.

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Telmisartan and Hydrochlorothiazide Tablets During Pregnancy

Telmisartan has been classified by the US FDA as Pregnancy Category C (first trimester) and D (second and third trimesters.Hydrochlorothiazide has been classified by the US FDA as Pregnancy Category B.
Telmisartan and hydrochlorothiazide tablets can cause fetal harm when administered to a pregnant woman.
Use of medications that act on the renin-angiotensin system during the second and third trimesters of pregnancy reduces fetal renal function and increases fetal and neonatal morbidity and death.
Resulting oligohydramnios can be associated with fetal lung hypoplasia and skeletal deformations. Potential neonatal adverse effects include skull hypoplasia, anuria, hypotension, renal failure, and death. When pregnancy is detected, discontinue telmisartan tablets as soon as possible.

Do not use this medicine without your doctor's consent in case you are pregnant. Stop using this medication and inform your doctor immediately if you become pregnant during treatment.

Nursing Considerations

There is no information regarding the presence of telmisartan and hydrochlorothiazide tablets or telmisartan in human milk, the effects on the breastfed infant or the effects on milk production. Limited published studies report that hydrochlorothiazide is present in human milk. However, there is insufficient information to determine the effects of hydrochlorothiazide on the breastfed infant or the effects of hydrochlorothiazide on milk production. Telmisartan is present in the milk of lactating rats
Do not use this medication without telling your doctor if you are breast-feeding a baby.

Buy Generic Telmisartan 40 mg and Hydrochlorothiazide 12.5 mg (Sartel-H 40 mg) Pills Online From Only $0.95 per Pill

You can buy Generic Telmisartan 40 mg and Hydrochlorothiazide 12.5 mg Tablets online from Everest Online Pharmacy at a cheap price. Sartel-H 40 mg pills containing 40 mg of Telmisartan and 12.5 mg of Hydrochlorothiazide, manufactured by Intas Pharmaceuticals Ltd., India are supplied in a blister strip of 10 tablets. The 40 mg tablets cost only $0.95 per unit when you place an order for 240 tablets.

Disclaimer

The above information is provided to the best of our knowledge and in good faith. It is without a warrant of any kind, expressed or implied.

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