Rizatriptan Benzoate Tablets

Rizact (Generic Rizatriptan Benzoate Tablets) - Product Information

Rizact (Generic Rizatriptan Benzoate Tablets) is used for the acute treatment of attacks of migraine with or without aura in adults and pediatric patients 6 to 17 years of age. Rizatriptan should not be used for the management of hemiplegic or basilar migraine or for the prophylaxis of migraine.
Safety and efficacy have not been established for the management of cluster headaches.
Rizact tablets, the generic equivalent of Rizatriptan Benzoate are manufactured by Cipla limited, India in the strengths of 5 mg and 10 mg.
We also have in stock Generic Sumatriptan 25 mg, 50 mg and 100 mg Tablets (Suminat Tablets by Sun Pharma) which is also used for the treatment of migraine attacks with or without aura in adults.

Name of the Drug

Rizact Tablets.

Manufacturer of Rizact Tablets

Cipla Limited, India  
Website: www.cipla.com

Active Pharmaceutical Ingredient

The active ingredient present in Rizact tablets is Rizatriptan Benzoate.
Each tablet of Rizact contains Rizatriptan Benzoate equivalent to 5 mg or 10 mg of Rizatriptan.

Uses of Rizact Tablets (Generic Rizatriptan Benzoate Tablets)

Rizatriptan (Rizact Tablets) is used to treat acute migraine headaches with or without aura. It is not used to prevent migraine headaches and is not used for cluster headaches.
Rizatriptan works in the brain to relieve the pain from migraine headaches. It belongs to the group of medicines called triptans.
Many people find that their headaches go away completely after they take Rizatriptan. Other people find that their headaches are much less painful, and that they are able to go back to their normal activities even though their headaches are not completely gone.
Rizatriptan often relieves other symptoms that occur together with a migraine headache, such as nausea, vomiting, sensitivity to light, and sensitivity to sound.

Rizact Tablets (Rizatriptan Benzoate Tablets) - Dosage

Generic Rizatriptan Benzoate tablets should be administered exactly as suggested by your doctor. Your doctor may recommend a dosage of Rizact tablets depending on your age, medical requirement, body weight, other medical conditions, and current medications.
Adults: 5 or 10 mg single dose; separate repeat doses by at least two hours; maximum dose in a 24-hour period: 30 mg.
Pediatric patients 6 to 17 years: 5 mg single dose in patients less than 40 kg (88 lb); 10 mg single dose in patients 40 kg (88 lb) or more.
Adjust dose if co-administered with propranolol.
Rizact tablets work effectively if the amount of Rizatriptan is maintained at a constant level in the body. You should be systematic about the daily schedule for the medication such that you take tablets at about the same time every day, to get the maximum benefit of the medication. Continue taking Rizact tablets without missing any doses for the recommended treatment period and do not stop the treatment suddenly even if you feel better.

Please consult your doctor for exact dosing instructions. Rizact tablets (Generic Rizatriptan Benzoate tablets) should be administered in the dose prescribed by the doctor and for the duration recommended by the doctor.

Missed Dose

If you forget to take your regular Rizact tablet dose on time, take it whenever you remember.
If you remember the next day, skip the missed dose and take your scheduled dose. Do not take a double dose to compensate the missed dose.

Rizatriptan Benzoate Tablets Mechanism of Action

Current theories on the etiology of migraine headache suggest that symptoms are due to local cranial vasodilatation and/or to the release of vasoactive and pro-inflammatory peptides from sensory nerve endings in an activated trigeminal system.
The therapeutic activity of Rizatriptan in migraine can most likely be attributed to agonist effects at 5-HT1B/1D receptors on the extracerebral, intracranial blood vessels that become dilated during a migraine attack and on nerve terminals in the trigeminal system.
Activation of these receptors results in cranial vessel constriction, inhibition of neuropeptide release and reduced transmission in trigeminal pain pathways.

Storage Instructions for Rizact Tablets

Store Rizact Tablets (Generic Rizatriptan Benzoate Tablets) at controlled room temperature (20°C to 25°C),protected from heat, moisture, and sunlight. Excursions are permitted from 15°C to 30°C.
Retain the original packing of the medication and do not consume Rizact Tablets past its expiration date printed on the blister pack. Keep the pack of Generic Rizatriptan Benzoate Tablets away from the reach of children and pets. Do not dispose Rizact Tablets along with domestic waste or sewage. Consult your doctor or pharmacist about the correct method of disposal.

Contraindications

Rizact tablets are contraindicated in patients with a hypersensitivity to Rizatriptan Benzoate or any inactive ingredient present in tablets. Rizact tablets are also contraindicated in the following cases:

• History of ischemic heart disease or coronary artery vasospasm
• History of stroke or transient ischemic attack
• Peripheral vascular disease
• Ischemic bowel disease
• Uncontrolled hypertension
• Recent (within 24 hours) use of another 5-HT 1 agonist (e.g., another triptan), or of an ergotamine-containing medication
• Hemiplegic or basilar migraine
• MAO-A inhibitor used in the past 2 weeks

Overdose

No overdoses of Rizatriptan Benzoate (Rizact Tablets) were reported during clinical trials in adults.Some adult patients who received 40 mg of rizatriptan benzoate either a single dose or as two doses with a 2-hour interdose interval had dizziness and somnolence.
In a clinical pharmacology study in which 12 adult subjects received Rizatriptan Benzoate, at total cumulative doses of 80 mg (given within 4 hours), two of the subjects experienced syncope, dizziness, bradycardia including third degree AV block, vomiting, and/or incontinence.
In addition, based on the pharmacology of rizatriptan benzoate, hypertension or myocardial ischemia could occur after overdosage. Gastrointestinal decontamination, (i.e., gastric lavage followed by activated charcoal) should be considered in patients suspected of an overdose with Rizatriptan benzoate.
Clinical and electrocardiographic monitoring should be continued for at least 12 hours, even if clinical symptoms are not observed.

Warnings and Precautions

Myocardial ischemia, myocardial infarction, and Prinzmetal's angina:
Perform cardiac evaluation in patients with multiple cardiovascular risk factors
Arrhythmias:
Discontinue dosing if occurs
Chest/throat/neck/jaw pain, tightness, pressure, or heaviness:
Generally not associated with myocardial ischemia; Evaluate patients at high risk
Cerebral hemorrhage, subarachnoid hemorrhage, and stroke:
Discontinue dosing if occurs
Gastrointestinal ischemic events, peripheral vasospastic reactions:
Discontinue dosing if occurs
Medication overuse headache:
Detoxification may be necessary
Serotonin syndrome:
Discontinue dosing if occurs

Side Effects of Rizatriptan Benzoate (Rizact Tablets)

The most common side effects in adults with an incidence rate of 5% or more and greater than placebo were : asthenia/fatigue, somnolence, pain/pressure sensation and dizziness.

Rizatriptan Benzoate (Rizact Tablets) During Pregnancy

Rizatriptan Benzoate (Rizact Tablets) has been classified by the US FDA as Pregnancy Category C.
There are no adequate and well controlled studies in pregnant women. Rizatriptan benzoate should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus.
In a general reproductive study in rats, birth weights and pre- and post-weaning weight gain were reduced in the offspring of females treated prior to and during mating and throughout gestation and lactation with doses of 10 and 100 mg/kg/day.
In a pre- and postnatal developmental toxicity study in rats, an increase in mortality of the offspring at birth and for the first 3 days after birth, a decrease in pre- and post-weaning weight gain, and decreased performance in a passive avoidance test (which indicates a decrease in learning capacity of the offspring) were observed at doses of 100 and 250 mg/kg/day.
Do not use this medicine without your doctor's consent in case you are pregnant. Stop using this medication and inform your doctor immediately if you become pregnant during treatment.

Nursing Considerations

It is not known whether this drug is excreted in human milk. Because many drugs are excreted in human milk, caution should be exercised when Rizatriptan Benzoate (Rizact Tablets) is administered to a nursing woman. Rizatriptan is extensively excreted in rat milk, with levels in milk at least 5-fold higher than levels in maternal plasma.
Do not use this medication without telling your doctor if you are breast-feeding a baby.

Buy Generic Rizatriptan Benzoate (Rizact 5 mg and 10 mg Tablets) Pills Online From Only $2.58 per Pill

You can buy Generic Rizatriptan Benzoate online from Everest Online Pharmacy at a cheap price. Rizact 5 mg and 10 mg pills, manufactured by Cipla Limited, India are supplied in a blister strip of 4 tablets. The 5 mg tablets cost only $2.58 per unit when you place an order for 24 tablets.

Disclaimer

The above information is provided to the best of our knowledge and in good faith. It is without a warrant of any kind, expressed or implied.

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