Propranolol Hydrochloride Tablets

Propranolol Hydrochloride Tablets (Ciplar Tablets) - Product Information

Propranolol Hydrochloride Tablets (Ciplar Tablets) are a beta-blocker medication that works by lowering your blood pressure and heart rate, making it easier for your heart to pump blood. It treats conditions like high blood pressure, tremors and atrial fibrillation.
It can also prevent migraine headaches by relaxing the blood vessels in your brain.
Ciplar tablets are manufactured by Cipla Limited, India in the strengths of 10 mg and 40 mg.
We also have in stock Spironolactone Tablets (Aldactone Tablets) which is also used to treat the same indications.

Name of the Drug

Ciplar Tablets .

Manufacturer of Ciplar Tablets

Cipla Limited, India  
Website: www.cipla.com

Active Pharmaceutical Ingredient

The active ingredient present in Ciplar tablets is Propranolol Hydrochloride. Each film-coated tablet of Ciplar contains 10 mg or 40 mg of Propranolol Hydrochloride.

Uses of Propranolol Hydrochloride Tablets (Ciplar Tablets)

Propranolol Hydrochloride Tablets (Ciplar Tablets) is used for the following indications:

• the control of hypertension;
• the management of angina pectoris;
• long-term management against re-infarction after recovery from acute myocardial infarction;
• the control of most forms of cardiac dysrhythmias;
• the prophylaxis of migraine;
• the management of essential tremor;
• relief of situational anxiety and generalised anxiety symptoms, particularly those of somatic type;
• prophylaxis of upper gastrointestinal bleeding in patients with portal hypertension and oesophageal varices;
• the adjunctive management of thyrotoxicosis and thyrotoxic crisis;
• management of hypertrophic obstructive cardiomyopathy;
• management of phaeochromocytoma peri-operatively (with an alpha-blocker).

Propranolol Hydrochloride Tablets (Ciplar Tablets) - Dosage

Generic Propranolol Hydrochloride tablets should be administered exactly as suggested by your doctor. Your doctor may recommend a dosage of Ciplar tablets depending on your age, medical requirement, body weight, other medical conditions, and current medications.
The dosage for adults for various indications is given below:
Hypertension
A starting dose of 80 mg twice a day may be increased by 80 mg per day at weekly intervals according to response. The usual dose range is 160 to 320 mg per day. With concurrent diuretic or other antihypertensive drugs a further reduction of blood pressure is obtained.
Angina, migraine and essential tremor
A starting dose of 40 mg two or three times daily may be increased by the same amount at weekly intervals according to patient response. An adequate response in migraine and essential tremor is usually seen in the range 80 to 160 mg/day and in angina in the range 120 to 240 mg/day.
Situational and generalised anxiety
A dose of 40 mg daily may provide short term relief of acute situational anxiety. Generalised anxiety, requiring longer term therapy, usually responds adequately to 40 mg twice daily which, in individual cases, may be increased to 40 mg three times daily. Treatment should be continued according to response. Patients should be reviewed after 6 to 12 months treatment.
Arrhythmias, anxiety tachycardia, hypertrophic obstructive cardiomyopathy and thyrotoxicosis
A dosage range of 10 to 40 mg three or four times a day usually achieves the required response.
Post myocardial infarction:
Treatment should start between days 5 and 21 after myocardial infarction, with an initial dose of 40 mg four times a day for 2 or 3 days. In order to improve compliance, the total daily dosage may thereafter be given as 80 mg twice a day.
Portal hypertension:
Dosage should be titrated to achieve approximately 25% reduction in resting heart rate. Dosage should begin with 40 mg twice daily, increasing to 80 mg twice daily depending on heart rate response. If necessary, the dose may be increased incrementally to a maximum of 160 mg twice daily.
Ciplar tablets work effectively if the amount of Propranolol Hydrochloride is maintained at a constant level in the body. You should be systematic about the daily schedule for the medication such that you take tablets at about the same time every day, to get the maximum benefit of the medication. Continue taking tablets without missing any doses for the recommended treatment period and do not stop the treatment suddenly even if you feel better.

Please consult your doctor for exact dosing instructions.Ciplar tablets (Generic Propranolol Hydrochloride tablets) should be administered in the dose prescribed by the doctor and for the duration recommended by the doctor.

Missed Dose

If you forget to take your regular Ciplar tablet dose on time, take it whenever you remember.
If you remember the next day, skip the missed dose and take your scheduled dose. Do not take a double dose to compensate the missed dose.

Propranolol Hydrochloride Tablets Mechanism of Action

The mechanism of the antihypertensive effect of propranolol has not been established.
Among factors that contribute to the antihypertensive action are: (1) decreased cardiac output, (2) inhibition of renin release by the kidneys, and (3) diminution of tonic sympathetic nerve outflow from vasomotor centers in the brain.
Although total peripheral resistance may increase initially, it readjusts to or below the pretreatment level with chronic use of propranolol. Effects of propranolol on plasma volume appear to be minor and somewhat variable.

Storage Instructions for Propranolol Hydrochloride Tablets (Ciplar Tablets)

Store Ciplar tablets at controlled room temperature (20°C to 25°C),protected from heat, moisture, and sunlight. Excursions are permitted from 15°C to 30°C.
Retain the original packing of the medication and do not consume past its expiration date printed on the blister pack. Keep the pack of Propranolol Hydrochloride Tablets away from the reach of children and pets. Do not dispose Ciplar tablets along with domestic waste or sewage. Consult your doctor or pharmacist about the correct method of disposal.

Contraindications

Ciplar tablets are contraindicated in patients with a hypersensitivity to Propranolol Hydrochloride or any inactive ingredient present in tablets. Ciplar tablets are also contraindicated in the following cases:
Cardiogenic shock or decompensated heart failure
Sinus bradycardia, sick sinus syndrome, and greater than first-degree block unless a permanent pacemaker is in place
Bronchial asthma

Overdose

Most overdoses of propranolol are mild and respond to supportive care.
Propranolol is not significantly dialyzable.
Hypotension and bradycardia have been reported following propranolol overdose and should be treated appropriately. Glucagon can exert potent inotropic and chronotropic effects and may be particularly useful for the treatment of hypotension or depressed myocardial function after a propranolol overdose.
Monitor the electrocardiogram, pulse, blood pressure, neurobehavioral status and intake and output balance. Isoproterenol and aminophylline may be used for bronchospasm.

Warnings and Precautions

Cardiac Ischemia after Abrupt Discontinuation:
Following abrupt discontinuation of therapy with beta-blockers, exacerbations of angina pectoris and myocardial infarction have occurred.
Cardiac Failure
Beta-blockers, like , can cause depression of myocardial contractility and may precipitate heart failure and cardiogenic shock. If signs or symptoms of heart failure develop, treat the patient according to recommended guidelines.
Maintain During Major Surgery:
Chronically administered beta-blocking therapy, including Propranolol Hydrochloride tablets, should not be routinely withdrawn prior to major surgery; however, the impaired ability of the heart to respond to reflex adrenergic stimuli may augment the risks of general anesthesia and surgical procedures.
Hypoglycemia:
Beta-blockers may prevent early warning signs of hypoglycemia, such as tachycardia, and increase the risk for severe or prolonged hypoglycemia at any time during treatment, especially in patients with diabetes mellitus or children and patients who are fasting (i.e., surgery, not eating regularly, or are vomiting). If severe hypoglycemia occurs, patients should be instructed to seek emergency treatment.
Thyrotoxicosis:
Propranolol Hydrochloride tablets may mask clinical signs of hyperthyroidism, such as tachycardia. Avoid abrupt withdrawal of beta-blockade, which may precipitate a thyroid storm.
Thyrotoxicosis:
Propranolol Hydrochloride tablets may mask clinical signs of hyperthyroidism, such as tachycardia. Avoid abrupt withdrawal of beta-blockade, which may precipitate a thyroid storm.
Bradycardia:
Bradycardia, including sinus pause, heart block, and cardiac arrest have occurred with the use of Propranolol Hydrochloride tablets. Patients with first-degree atrioventricular block, sinus node dysfunction, or conduction disorders (including Wolff-Parkinson-White) may be at increased risk.
Reduced Effectiveness of Epinephrine in Treating Anaphylaxis:
Beta-adrenergic blocker-treated patients treated with epinephrine for a severe anaphylactic reaction may be less responsive to the typical doses of epinephrine. In these patients, consider other medications (e.g., intravenous fluids, glucagon.

Side Effects of Propranolol Hydrochloride Tablets (Ciplar Tablets)

Propranolol Hydrochloride tablets (Ciplar tablets)Side effects occurring at a rate of 3% or more, excluding those reported more commonly in placebo, encountered in the placebo-controlled hypertension trials and plausibly related to treatment are Fatigue, Dizziness (except vertigo) and Constipation

Propranolol Hydrochloride During Pregnancy

Propranolol Hydrochloride Tablets (Ciplar Tablets) has been classified by the US FDA as Pregnancy Category C.
Prolonged experience with propranolol in pregnant women over several decades, based on published interventional and observational studies, has not identified a drug associated risk of major birth defects, miscarriage, or other adverse maternal outcomes.
Bradycardia, hypoglycemia, and respiratory depression have been observed with use of beta-blockers, including propranolol, in utero near the time of delivery. There are inconsistent reports of intrauterine growth restriction with beta-blocker use, including propranolol, during pregnancy. Untreated hypertension during pregnancy can lead to serious adverse outcomes for the mother and the fetus.
Do not use this medicine without your doctor's consent in case you are pregnant. Stop using this medication and inform your doctor immediately if you become pregnant during treatment.

Nursing Considerations

Propranolol is present in human milk at low levels, but the related risk to a breastfed infant is unknown. There are no data on the effects of propranolol on milk production.
The developmental and health benefits of breastfeeding should be considered along with the mother’s clinical need for Propranolol Hydrochloride Tablets (Ciplar Tablets) and any potential adverse effects on the breastfed child from Propranolol Hydrochloride or from the underlying maternal condition.
Do not use this medication without telling your doctor if you are breast-feeding a baby.

Buy Generic Propranolol Hydrochloride 10 mg and 40 mg Pills Online From Only $0.13 per Pill

You can buy Generic Propranolol Hydrochloride tablets online from Everest Online Pharmacy at a cheap price. Ciplar tablets 10 mg and 40 mg pills, manufactured by Cipla Limited, India, are supplied in a blister strip of 10 tablets. The 10 mg tablets cost only $0.13 per unit when you place an order for tablets.

Disclaimer

The above information is provided to the best of our knowledge and in good faith. It is without a warrant of any kind, expressed or implied.

Shipping Restriction