Paracetamol Tablets

Calpol (Generic Paracetamol or Acetaminophen Tablets) - Product Information

Calpol (Generic Paracetamol or Acetaminophen Tablets) is an over-the-counter analgesic (pain reliever) and antipyretic (fever reducer) that is used to temporarily relieve mild-to-moderate pain and fever. This drug is used to treat mild to moderate pain (from headaches, menstrual periods, toothaches, backaches, osteoarthritis, or cold/flu aches and pains) and to reduce fever.
It is commonly included as an ingredient in cold and flu medications and is also used on its own.
Paracetamol is classified as a mild analgesic. It is commonly used for the relief of headaches and other minor aches and pains and is a major ingredient in numerous cold and flu remedies.
In combination with opioid analgesics, Paracetamol can also be used in the management of more severe pain such as post-surgical pain and providing palliative care in advanced cancer patients.
Calpol tablets are manufactured by GlaxoSmithKline Pharmaceuticals Limited, India, in the strengths of 500 mg and 650 mg .
We also have in stock Diclofenac Sodium Tablets (Voveran) which is used to reduce the pain and inflammation which are characteristic symptoms in musculoskeletal conditions such as arthritis, rheumatoid arthritis, polymyositis, dermatomyositis, osteoarthritis, Temporomandibular Joint disorders (TMJ), spondylarthritis, ankylosing spondylitis, and gout attacks.

Name of the Drug

Calpol Tablets. Calpol tablets are also known as Panadol, Calpol, Alvedon and Tylenol.

Manufacturer of Calpol Tablets

GlaxoSmithKline Pharmaceuticals Limited, India  
Website: www.gsk-india.com

Active Pharmaceutical Ingredient

The active ingredient present in Calpol tablets is Paracetamol. Each Calpol tablet contains 500 mg or 650 mg of Paracetamol (Acetaminophen).

Uses of Paracetamol Tablets (Calpol Tablets)

Paracetamol(Acetaminophen) is a mild analgesic and antipyretic, and is recommended for the treatment of most painful and febrile conditions, for example, headache including migraine, toothache, neuralgia, colds and influenza, sore throat, backache, rheumatic pain and dysmenorrhoea.

Calpol (Generic Paracetamol Tablets) - Dosage

Generic Paracetamol tablets should be administered exactly as suggested by your doctor. Your doctor may recommend a dosage of Calpol tablets depending on your age, medical requirement, body weight, other medical conditions, and current medications.
Adults, Elderly and Children over 16 years:
Two tablets every four hours as required. Not more than eight tablets of 500 mg in 24 hours Do not take for more than 3 days without consulting your doctor. Maximum daily dose: 4000 mg
These doses should not be given more frequently than every four hours nor should more than four doses be given in any 24 hour period.
Paediatric population
Not recommended for children under 10 years of age.
Children aged 10 to 15 years:
One 500 mg tablet every four to six hours when necessary to a maximum of four doses in 24 hours. Do not take for more than 3 days without consulting your doctor.
These doses should not be repeated more frequently than every four to six hours nor should more than four doses be given in any 24 hour period.
Calpol tablets work effectively if the amount of Paracetamol is maintained at a constant level in the body. You should be systematic about the daily schedule for the medication such that you take tablets at about the same time every day, to get the maximum benefit of the medication. Continue taking Calpol tablets without missing any doses for the recommended treatment period and do not stop the treatment suddenly even if you feel better.

Please consult your doctor for exact dosing instructions. Calpol tablets (Generic Paracetamol tablets) should be administered in the dose prescribed by the doctor and for the duration recommended by the doctor.

Missed Dose

If you forget to take your regular Calpol tablet dose on time, take it whenever you remember.
If you remember the next day, skip the missed dose and take your scheduled dose. Do not take a double dose to compensate the missed dose.

Paracetamol Mechanism of Action – How do Calpol Tablets Work?

It is not clear exactly how Paracetamol (Acetaminophen) works. However, it is thought to work by blocking chemical messengers in the brain that let us know when we're in pain and by affecting the chemical messengers that regulate our body temperature. The evidence suggests that paracetamol inhibits the production of prostaglandins, which are made by the body to deal with illness and injury. It's also thought to act on the serotonergic, opioid, nitric oxide and cannabinoid pathways.

Storage Instructions for Calpol Tablets (Generic Paracetamol)

Store Calpol tablets at controlled room temperature (20°C to 25°C),protected from heat, moisture, and sunlight. Excursions are permitted from 15°C to 30°C.
Retain the original packing of the medication and do not consume Paracetamol tablets past its expiration date printed on the blister pack. Keep the pack of Calpol tablets away from the reach of children and pets. Do not dispose Calpol tablets along with domestic waste or sewage. Consult your doctor or pharmacist about the correct method of disposal.

Contraindications

Calpol tablets are contraindicated in patients with a hypersensitivity to Paracetamol or any inactive ingredient present in Calpol tablets.

Overdose

Liver damage is possible in adults who have taken 10g or more of paracetamol. Ingestion of 5g or more of paracetamol may lead to liver damage if the patient has risk factors.
Risk Factors:
is on long term treatment with carbamazepine, phenobarbitone, phenytoin, primidone, rifampicin, St. John's Wort or other drugs that induce liver enzymes, or
• regularly consumes ethanol in excess of recommended amounts, or
• is likely to be glutathione deplete e.g. eating disorders, cystic fibrosis, HIV infection, starvation, cachexia.
Symptoms:
Symptoms of paracetamol overdosage, in the first 24 hours are pallor, nausea, vomiting, anorexia and abdominal pain. Liver damage may become apparent 12 to 48 hours after ingestion. Abnormalities of glucose metabolism and metabolic acidosis may occur. In severe poisoning, hepatic failure may progress to encephalopathy, disseminated intravascular coagulation, haemorrhage, hypoglycaemia, cerebral oedema, gastrointestinal bleeding and death. Acute renal failure with acute tubular necrosis, strongly suggested by loin pain, haematuria and proteinuria may develop even in the absence of severe liver damage.
Cardiac arrhythmias and pancreatitis have been reported.
Management:
Immediate treatment is essential in the management of paracetamol overdose. Despite a lack of significant early symptoms, patients should be referred to hospital urgently for immediate medical attention. Symptoms may be limited to nausea or vomiting and may not reflect the severity of overdose or the risk of organ damage. Management should be in accordance with established treatment guidelines (see BNF overdose section).
Treatment with activated charcoal should be considered if the overdose has been taken within 1 hour. Plasma paracetamol concentration should be measured at 4 hours or later after ingestion (earlier concentrations are unreliable). Treatment with N-acetylcysteine may be used up to 24 hours after ingestion of paracetamol, however, the maximum protective effect is obtained up to 8 hours post-ingestion.

Warnings and Precautions

Do Not Exceed Dosage:
Administration of Acetaminophen in doses higher than recommended (by all routes of administration and from all acetaminophen-containing products including combination products) may result in hepatic injury, including the risk of liver failure and death.Do not exceed the maximum recommended daily dose of Acetaminophen. Do not take for more than 3 days without consulting a doctor. If symptoms persist consult your doctor.
Patients with Hepatic Impairment:
Use caution when administering Paracetamol in patients with the following conditions: hepatic impairment or active hepatic disease, in cases of alcoholism, chronic malnutrition, severe hypovolemia, or severe renal impairment (creatinine clearance 30 mL/min or less).
Care is advised in the administration of paracetamol to patients with severe renal or severe hepatic impairment. The hazard of overdose is greater in those with non-cirrhotic alcoholic liver disease.
Skin Rash:
Discontinue Acetaminophen immediately at the first appearance of skin rash and if symptoms associated with allergy or hypersensitivity occur. Do not use in patients with acetaminophen allergy.
Children Under The Age Of 10:
Not recommended for children under the age of 10 years. Keep out of the reach of children.
High Anion Gap Metabolic Acidosis:
Cases of high anion gap metabolic acidosis (HAGMA) due to pyroglutamic acidosis have been reported in patients with severe illness such as severe renal impairment and sepsis, or in patients with malnutrition or other sources of glutathione deficiency (e.g. chronic alcoholism) who were treated with paracetamol at therapeutic dose for a prolonged period or a combination of paracetamol and flucloxacillin. If HAGMA due to pyroglutamic acidosis is suspected, prompt discontinuation of paracetamol and close monitoring is recommended. The measurement of urinary 5-oxoproline may be useful to identify pyroglutamic acidosis as underlying cause of HAGMA in patients with multiple risk factors.
Overdose:
Immediate medical advice should be sought in the event of an overdose, even if you feel well, because of the risk of delayed, serious liver damage.

Effects On Ability To Drive And Use Machines

Paracetamol has no influence on the ability to drive and use machines.

Side Effects of Calpol ( Paracetamol Tablets)

The most common side effects in patients treated with Calpol ( Paracetamol Tablets) were nausea, vomiting, headache, and insomnia in adult patients and nausea, vomiting, constipation, pruritus, agitation, and atelectasis in pediatric patients.

Paracetamol Tablets During Pregnancy

Paracetamol Tablets (Calpol) has been classified by the US FDA as Pregnancy Category C.
Epidemiological studies in human pregnancy have shown no ill effects due to paracetamol used in the recommended dosage, but patients should follow the advice of their doctor regarding its use. A large amount of data on pregnant women indicate neither malformative, nor feto/neonatal toxicity. Epidemiological studies on neurodevelopment in children exposed to paracetamol in utero show inconclusive results. If clinically needed, Paracetamol can be used during pregnancy if clinically needed however it should be used at the lowest effective dose for the shortest possible time and at the lowest possible frequency.
Do not use this medicine without your doctor's consent in case you are pregnant. Stop using this medication and inform your doctor immediately if you become pregnant during treatment.

Nursing Considerations

Paracetamol is excreted in breast milk but not in a clinically significant amount. Available published data do not contraindicate breast feeding.
Do not use this medication without telling your doctor if you are breast-feeding a baby.

Buy Generic Paracetamol 500 mg and 650 mg Pills Online From Only $0.12 per Pill

You can buy Generic Paracetamol tablets online from Everest Online Pharmacy at a cheap price. Calpol 500 mg and 650 mg pills, manufactured by GlaxoSmithKline Pharmaceuticals Limited, India, are supplied in a blister strip of 10 tablets. The 500 mg tablets cost only per $0.12 unit when you place an order for 300 tablets.

Disclaimer

The above information is provided to the best of our knowledge and in good faith. It is without a warrant of any kind, expressed or implied.

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