Minocycline Hydrochloride Tablets

Generic Minocycline Hydrochloride Tablets (Divaine Tablets) - Product Information

Divaine(Generic Minocycline Hydrochloride tablets) is indicated to treat only inflammatory lesions of non-nodular moderate to severe acne vulgaris in patients 12 years of age and older. It is also commonly used to treat the following infections caused by certain bacteria such as Infections from tick bites, Certain sexually transmitted infections, Respiratory tract infections, such as bronchitis, pneumonia, or sinusitis, certain eye infections, plague, cholera, anthrax, certain infections spread from animals, certain infections when penicillin cannot be used and specific infections caused by parasites.
To reduce the development of drug-resistant bacteria as well as to maintain the effectiveness of other antibacterial drugs, Minocycline Hydrochloride tablets should be used only as indicated.
Divaine tablets are manufactured by Cipla Limited, India, in the strengths of 50 mg and 100 mg.
We also have in stock Zoxan Tablets (Generic Ciprofloxacin Hydrochloride Tablets) which is also used to treat are prescribed as oral therapy for the effective treatment of various types of bacterial infections of the eye, ears, teeth, chest, prostate, digestive system, bone and joint.

Name of the Drug

Divaine Tablets.

Manufacturer of Divaine Tablets

Cipla Limited, India  
Website: www.cipla.com

Active Pharmaceutical Ingredient

The active ingredient present in Divaine tablets is Minocycline Hydrochloride. Each film-coated tablet of Divaine contains Minocycline Hydrochloride equivalent to 50 mg or 100 mg of Minocycline.

Uses of Minocycline Hydrochloride Tablets (Divaine Tablets)

Minocycline Hydrochloride Tablets (Divaine Tablets) are indicated in the treatment of the following infections due to susceptible microorganisms: acne, gonorrhoea, non-gonococcal urethritis, syphilis, prostatitis, acute and chronic bronchitis, bronchiectasis, lung abscess, pneumonia, ear, nose and throat infections, urinary tract infections, pelvic inflammatory disease, skin and soft tissue infections, ophthalmological infections, nocardiosis, prophylactic treatment of asymptomatic meningococcal carriers, pre- and post-operative prophylaxis of infection, trachoma, and inclusion conjunctivitis.

Minocycline Hydrochloride Tablets (Divaine Tablets) - Dosage

Generic Minocycline Hydrochloride tablets should be administered exactly as suggested by your doctor. Your doctor may recommend a dosage of Divaine tablets depending on your age, medical requirement, body weight, other medical conditions, and current medications.
Acne:
50 mg twice daily for a minimum of 6 weeks. Treatment of acne should be continued for a minimum of 6 weeks. If, after 6 months, there is no satisfactory response, Divaine tablets should be discontinued and other therapies considered. If Divaine tablets are to be continued for longer than 6 months, patients should be monitored at least every 3 months thereafter for signs and symptoms of hepatitis or systemic lupus erythematosus (SLE) or unusual pigmentation.
Uncomplicated Gonococcal Infections other than Urethritis and Anorectal Infections:
The dosage for treating uncomplicated gonococcal infections in men is 200 mg initially, followed by 100 mg every 12 hours for a minimum of 4 days, with post-therapy cultures within 2 to 3 days. More prolonged therapy may be required in the case of Adult females.
Uncomplicated Gonococcal Urethritis in Men:
100 mg, every 12 hours, for 5 days is recommended.
Uncomplicated Non-Gonococcal Urethral Infection in Adults Caused by Chlamydia trachomatis or Ureaplasma urealyticum:
100 mg orally, every 12 hours, for at least 7 days.
Syphilis:
The recommended dosage of Divaine tablets has to be administered over a period of 10 to 15 days. Close follow-up, including laboratory tests, is strongly recommended.
Pneumonia Caused By Susceptible organisms:
The normal dosage of Divaine tablets is 200 mg initially, followed by 100 mg every 12 hours. The alternative dosage regimen if more frequent doses are preferred, two or four 50 mg tablets may be given initially, followed by one 50 mg four times daily. Treatment should be continued for at least 24 to 48 hours after symptoms and fever have subsided.
Meningococcal Carrier State:
The usual dosage of Divaine tablets for adults is 100 mg, every 12 hours, for 5 days.

For children (above 8 years of age) the usual dosage of Divaine tablets is 50 mg every 12 hours. Minocycline is not recommended for children below 8 years of age.

Divaine tablets work effectively if the amount of Minocycline is maintained at a constant level in the body. You should be systematic about the daily schedule for the medication such that you take Divaine tablets at about the same time every day, to get the maximum benefit of the medication. Continue taking tablets without missing any doses for the recommended treatment period and do not stop the treatment suddenly even if you feel better.
Please consult your doctor for exact dosing instructions.Divaine tablets (Generic Minocycline Hydrochloride tablets) should be administered in the dose prescribed by the doctor and for the duration recommended by the doctor.

Missed Dose

If you forget to take your regular Divaine tablet dose on time, take it whenever you remember.
If you remember the next day, skip the missed dose and take your scheduled dose. Do not take a double dose to compensate the missed dose.

Minocycline Hydrochloride Mechanism of Action – How do Divaine Tablets Work?

The tetracyclines are primarily bacteriostatic and are thought to exert their antimicrobial effect by the inhibition of protein synthesis. The tetracyclines, including Minocycline(Divaine tablets), have a similar antimicrobial spectrum of activity against a wide range of gram-positive and gram-negative organisms.
Cross-resistance of these organisms to Tetracycline is common.

Storage Instructions for Divaine (Generic Minocycline Hydrochloride Tablets)

Store Divaine tablets at controlled room temperature (20°C to 25°C),protected from heat, moisture, and sunlight. Excursions are permitted from 15°C to 30°C.
Retain the original packing of the medication and do not consume Divaine tablets past its expiration date printed on the blister pack. Keep the pack of Generic Minocycline tablets away from the reach of children and pets. Do not dispose Divaine tablets along with domestic waste or sewage. Consult your doctor or pharmacist about the correct method of disposal.

Contraindications

Divaine tablets are contraindicated in patients with a hypersensitivity to Minocycline Hydrochloride or any inactive ingredient present in Divaine tablets. Divaine tablets are also contraindicated in the following cases:
individuals with a known hypersensitivity to tetracyclines.

Overdose

The adverse events more commonly seen in overdose are dizziness, nausea, and vomiting. No specific antidote for Minocycline (Divaine tablets) is known.
In case of overdosage, discontinue medication, treat symptomatically, and institute supportive measures. Minocycline is not removed in significant quantities by haemodialysis or peritoneal dialysis.

Warnings and Precautions

Tooth Development
Minocycline, like other tetracycline-class antibiotics, can cause fetal harm when administered to a pregnant woman. If any tetracycline is used during pregnancy or if the patient becomes pregnant while taking these drugs, the patient should be apprised of the potential hazard to the fetus.
Skeletal Development
All tetracyclines form a stable calcium complex in any bone-forming tissue. A decrease in the fibula growth rate has been observed in premature human infants given oral tetracycline in doses of 25 mg/kg every six hours. This reaction was shown to be reversible when the drug was discontinued.
Use in Pregnancy
Results of animal studies indicate that tetracyclines cross the placenta, are found in fetal tissues, and can have toxic effects on the developing fetus
Dermatologic Reaction
Drug Rash with Eosinophilia and Systemic Symptoms (DRESS) including fatal cases has been reported with minocycline use. Fixed drug eruptions have occurred with minocycline and other tetracyclines.
Antianabolic Action
The antianabolic action of the tetracyclines may cause an increase in blood urea nitrogen (BUN). While this is not a problem in those with normal renal function, in patients with significantly impaired function, higher serum levels of tetracycline may lead to azotemia, hyperphosphatemia, and acidosis.
Photosensitivity
Photosensitivity manifested by an exaggerated sunburn reaction has been observed in some individuals taking tetracyclines. This has been reported with minocycline.
Central Nervous System
Central nervous system side effects including lightheadedness, dizziness, or vertigo have been reported with minocycline therapy. Patients who experience these symptoms should be cautioned about driving vehicles or using hazardous machinery while on minocycline therapy.
Clostridium difficile-Associated Diarrhea
Clostridium difficile-associated diarrhea (CDAD) has been reported with use of nearly all antibacterial agents, including minocycline, and may range in severity from mild diarrhea to fatal colitis. Treatment with antibacterial agents alters the normal flora of the colon leading to overgrowth of C. difficile.
Intracranial Hypertension
Intracranial hypertension (IH, pseudotumor cerebri) has been associated with the use of tetracyclines including minocycline. Clinical manifestations of IH include headache, blurred vision, diplopia, and vision loss; papilledema can be found on fundoscopy.

Side Effects of Minocycline Hydrochloride Tablets (Divaine Tablets)

The most commonly observed Minocycline Hydrochloride Tablets (Divaine Tablets) side effects with an incidence rate of 5% or more are headache, fatigue, dizziness, and pruritus. The following side effects have been observed in patients receiving Tetracyclines:

• Body as a Whole: Fever, and discolouration of secretions.
• Gastrointestinal: Anorexia, nausea, vomiting, diarrhoea, dyspepsia, stomatitis, glossitis, dysphagia, enamel hypoplasia, enterocolitis, pseudomembranous colitis, pancreatitis, inflammatory lesions (with monilial overgrowth) in the oral and anogenital regions. Instances of oesophagitis and oesophageal ulcerations have been reported in patients taking the tetracycline-class antibiotics in capsule and tablet form. Most of these patients took the medication immediately before going to bed.
• Genitourinary: Vulvovaginitis.
• Hepatic Toxicity: Hyperbilirubinaemia, hepatic cholestasis, increases in liver enzymes, fatal hepatic failure, and jaundice. Hepatitis, including autoimmune hepatitis and liver failure have been reported.
• Skin: Alopecia, erythema nodosum, hyperpigmentation of nails, pruritus, photosensitivity toxic epidermal necrolysis, and vasculitis. Maculopapular and erythematous rashes. Exfoliative dermatitis has been reported. Fixed drug eruptions have been reported. Lesions occurring on the glans penis have caused balanitis. Erythema multiforme and Stevens-Johnson syndrome have been reported.. Pigmentation of the skin and mucous membranes has been reported.
• Respiratory: Cough, dyspnoea, bronchospasm, exacerbation of asthma, and pneumonitis.
• Renal Toxicity: Interstitial nephritis. Elevations in BUN have been reported and are apparently dose-related .Reversible acute renal failure has been reported.
• Musculoskeletal: Arthralgia, arthritis, bone discolouration, myalgia, joint stiffness, and joint swelling.
• Hypersensitivity Reactions: Urticaria, angioneurotic oedema, polyarthralgia, anaphylaxis/anaphylactoid reaction (including shock and fatalities), anaphylactoidpurpura, myocarditis, pericarditis, polyarteritisnodosa, exacerbation of systemic lupus erythematosus and pulmonary infiltrates with eosinophilia have been reported. A transient lupus-like syndrome and serum sickness-like reactions also have been reported.
• Blood: Agranulocytosis, haemolytic anaemia, thrombocytopenia, leucopenia, neutropenia, pancytopenia and eosinophilia have been reported.
• Central Nervous System: Convulsions, dizziness, hypaesthesia, paraesthesia, sedation, and vertigo. Bulging fontanels in infants and benign intracranial hypertension (pseudotumourcerebri) in adults have been reported. Headache has also been reported.
• Infections and infestations: Oral and anogenital candidiasis, vulvovaginitis.
• Other: Thyroid cancer has been reported in the postmarketing setting in association with minocycline products. When minocycline therapy is given over prolonged periods, monitoring for signs of thyroid cancer should be considered. When given over prolonged periods, tetracyclines have been reported to produce brown-black microscopic discolouration of the thyroid gland. Cases of abnormal thyroid function have been reported. Tooth discolouration in children less than 8 years of age, and also in adults, has been reported. Oral cavity discolouration (including tongue, lips and gums) have been reported.Tinnitus and decreased hearing have been reported in patients on Minocycline Hydrochloride.

The following syndromes have been reported. In some cases involving these syndromes, death has been reported. As with other serious side effects, if any of these syndromes are recognized, Minocycline Tablets (Divaine) should be discontinued immediately:

• Hypersensitivity syndrome consisting of cutaneous reaction (such as rash or exfoliative dermatitis), eosinophilia, and one or more of the following: hepatitis, pneumonitis, nephritis, myocarditis, and pericarditis. Fever and lymphadenopathy may be present.
• Lupus-like syndrome consisting of positive antinuclear antibody; arthralgia, arthritis, joint stiffness or joint swelling; and one or more of the following: fever, myalgia, hepatitis, rash, and vasculitis.
• Serum sickness-like syndrome consisting of fever; urticaria or rash; and arthralgia, arthritis, joint stiffness, or joint swelling.

Minocycline Hydrochloride Tablets (Divaine) During Pregnancy

Minocycline Hydrochloride tablets (Divaine) has been classified by the US FDA as Pregnancy Category D.
Results of animal studies indicate that tetracyclines cross the placenta, are found in foetal tissues and can have toxic effects on the developing foetus (often related to retardation of skeletal development). Evidence of embryotoxicity has also been noted in animals treated early in pregnancy. The use of drugs of the tetracycline class during tooth development (last half of pregnancy, infancy, and childhood up to the age of 12 years) may cause permanent discolouration of the teeth (yellow to grey-brown).
This adverse reaction is more common during long-term use of the drugs, but has been observed following repeated short-term courses. Enamel hypoplasia has also been reported.
Do not use this medicine without your doctor's consent in case you are pregnant. Stop using this medication and inform your doctor immediately if you become pregnant during treatment.

Nursing Considerations

Tetracyclines are excreted in human milk. Because of the potential for serious adverse reactions in nursing infants from the tetracyclines, a decision should be made whether to discontinue nursing or discontinue the drug, taking into account the importance of the drug to the mother.
Do not use this medication without telling your doctor if you are breast-feeding a baby.

Buy Generic Minocycline 50 mg and 100 mg Pills (Divaine) Online From Only $0.92 per Pill

You can buy Generic Minocycline Hydrochloride tablets online from Everest Online Pharmacy at a cheap price. Divaine 50 mg and 100 mg pills, manufactured by Cipla Limited, India, are supplied in a blister strip of 10 tablets. The 50 mg tablets cost only $0.92 per unit when you place an order for 180 tablets.

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