Methotrexate Tablets

Methotrexate Tablets (Neotrexate) - Product Information

Neotrexate is an antimetabolite and antifolate drug used for the treatment of various cancers: breast, skin, head and neck, leukemia, lymphoma, lung, osteosarcoma, bladder, and trophoblastic neoplasms, autoimmune diseases (rheumatoid arthritis, psoriasis, psoriatic arthritis, and Crohn's disease), ectopic pregnancy, and eczema.
Methotrexate Tablets are also used for the initiation of medical abortions. Neotrexate tablets successfully prevents the growth of fast differentiating cells such as cancer cells, bone marrow cells, and skin cells.
Although Neotrexate tablets in high doses was initially used as an anti-cancer drug, it is also used as first-line therapy in the treatment of inflammatory conditions such as severe psoriasis and rheumatoid arthritis in low doses.
Neotrexate is available in our online pharmacy in the form of tablets of 2.5 mg strength for oral administration.
We also have in stock Naprosyn Tablets (Generic Naproxen Sodium Tablets) which is also used to to alleviate pain and inflammation symptoms such as redness, swelling and heat associated with various medical conditions such as arthritis, sprains and strains, backache, ankylosing spondylitis, tendinitis, bursitis, menstrual cramps, and gout.

Name of the Drug

Neotrexate. Methotrexate Tablets are also available under other brand names including Rheumatrex, Trexall, MTX, and Amethopterin.

Manufacturer of Neotrexate Tablets

GlaxoSmithKline  
Website: www.gsk-india.com

Active Pharmaceutical Ingredient

The active ingredient present in Neotrexate tablets is Methotrexate. Each tablet of Neotrexate contains 2.5 mg of Methotrexate as the active ingredient.
The inactive ingredients present in Neotrexate tablets are lactose, magnesium stearate, pregelatinized starch NF, sodium hydroxide, and sodium starch glycolate.

Methotrexate Indications - What are Neotrexate Tablets Used For?

Methotrexate in the form of Neotrexate Tablets is used to treat cancer (acute lymphoblastic leukemia, acute lymphocytic leukemia, acute nonlymphocytic leukemia, bladder cancer, brain tumor, breast cancer, cervical cancer, choriocarcinoma, colorectal cancer, esophageal carcinoma, gastric cancer, head and neck cancer, hodgkin's lymphoma, lymphoma, meningeal leukemia, mycosis fungoides, neoplastic diseases, non-hodgkin's lymphoma, non-small cell lung cancer, osteosarcoma, ovarian cancer, pancreatic cancer, small cell lung cancer, soft tissue sarcoma, solid tumors, and trophoblastic disease), certain skin conditions (eczema), ectopic pregnancy, autoimmune diseases (bullous pemphigoid, pemphigoid, pemphigus, and systemic sclerosis), inflammatory conditions (cogan's syndrome, dermatomyositis, pityriasis rubra pilaris, psoriasis, rheumatoid arthritis, uveitis), and surgical complications (graft-versus-host disease).

Methotrexate - Dosage

Methotrexate tablets are used for the treatment of different types of diseases. Consult your doctor before starting the treatment because you will be recommended a dosage depending on your medical condition.
You may be advised to follow a distinctive dosage program consisting of a few days of medication followed by a gap of a few weeks with no medication. Be sure to cautiously follow your doctor's guidelines about the dosage and the dosage period.
Patients who have accidentally consumed an overdose of the tablets in the past have suffered severe and lethal side effects of Methotrexate tablets. During the course of Methotrexate tablets, you may be advised to undergo routine tests such as complete blood count, kidney and liver function tests, and liver biopsies to examine your response to the treatment.
Methotrexate is usually administered once or twice per week. It should not be consumed every day. You must use the exact dose for your condition, as recommended by your doctor. Some patients have experienced adverse effects in the past after accidental consumption of Methotrexate on a daily basis.
Please consult your doctor for exact dosing instructions. Neotrexate tablets (Generic Methotrexate tablets) should be administered in the dose prescribed by the doctor and for the duration recommended by the doctor.

Methotrexate Tablets - Missed Dose

If you forget to take a dose of Methotrexate tablets, let your doctor know immediately. Your doctor will advise you on the future course of action.

Methotrexate Mechanism of Action – How Does Methotrexate Work?

The antimetabolite, methotrexate exerts its mechanism of action by preventing the metabolism the folic acid required for cell growth. Body cells require folic acid for DNA production. By inhibiting folic acid, Methotrexate hinders the cell's ability to repair and replicate its DNA.
This affects the growth of cells. Although Methotrexate targets normal body cells as well as cancer cells, it has more affinity towards fast growing cells such as tumor cells and bone marrow cells. The correct mechanism of action of Methotrexate to reduce inflammation (pain, swelling, stiffness) in rheumatoid arthritis is still unknown.

Storage

Store Methotrexate tablets at controlled room temperature (20°C to 25°C), protected from moisture, sunlight, and heat. Excursions are permitted from 15°C to 30°C.
Make sure that the pack of Neotrexate tablets are away from the reach of children and pets. Retain the original packing of the medication and do not use Methotrexate Tablets beyond its expiration date.
Do not discard Neotrexate tablets along with domestic waste or sewage. Consult your doctor or pharmacist about the correct method of disposal.

Contraindications

Methotrexate tablets are contraindicated in patients with a history of severe hypersensitivity reactions, including anaphylaxis, to Methotrexate or any inactive ingredient present in tablets.
Methotrexate tablets are also contraindicated in pregnant women receiving Methotrexate Tablets for treatment of non-neoplastic diseases.

Overdose

Overdosage, including fatal overdosage, has occurred with Methotrexate.
Manifestations of methotrexate overdosage include adverse reactions reported at pharmacologic doses, particularly hematologic and gastrointestinal reactions (e.g., leukopenia, thrombocytopenia, anemia, pancytopenia, myelosuppression, mucositis, stomatitis, oral ulceration, nausea, vomiting, gastrointestinal ulceration, or gastrointestinal bleeding).
In some cases, no symptoms were reported; however, sepsis or septic shock, renal failure, and aplastic anemia were also reported.

Warnings and Precautions to be taken when using Methotrexate Tablets

Methotrexate is a potent medication capable of producing substantial toxicity. It should be administered for the treatment of serious diseases in patients who have already undergone less toxic treatment substitutes. Before starting the course of Methotrexate medication, patients should discuss their current medications, medical history, and allergies with their doctors.
Medical history
Inform your doctor in advance if you have kidney disease, a folate deficiency, pneumonia or lung disease, liver diseases (alcoholism, cirrhosis), blood cell disorder (anemia or leukopenia), bone marrow disorder, stomach ulcers, any type of infection; if you are breast feeding and if you are receiving radiation treatments.
Drug Interactions from Current Medications
Before starting your course of Methotrexate tablets, inform your doctor if you are using any of the following drugs azathioprine (Imuran); chloramphenicol (Chloromycetin); hydroxychloroquine (Plaquenil, Quineprox); retinol, tretinoin (Retin-A), isotretinoin (Accutane); steroids (prednisone and others); sulfa drugs such as Azulfidine, Bactrim, or Septra; phenytoin (Dilantin); probenecid (Benemid); tetracycline (Brodspec, Panmycin, Sumycin, Tetracap); theophylline (Elixophyllin, Slo-Bid, Theobid, Theo-Dur); gold treatments such as auranofin (Ridura); oral diabetes medications such as acetohexamide (Dymelor), chlorpropamide (Diabinese), glipizide (Glucotrol), glimepiride (Amaryl), or tolbutamide (Orinase); a penicillin antibiotic such as amoxicillin (Amoxil, Augmentin, Dispermox, Moxatag), ampicillin (Principen, Unasyn), dicloxacillin (Dycill, Dynapen), or penicillin (Bicillin L-A, PC Pen VK, Pfizerpen), and others; medicines that reduce stomach acid, such as esomeprazole (Nexium, Vimovo), lansoprazole (Prevacid), omeprazole (Prilosec, Zegerid), pantoprazole (Protonix), or rabeprazole (Aciphex); NSAIDs (non-steroidal anti-inflammatory drugs) such as ibuprofen (Motrin, Advil), diclofenac (Cataflam, Voltaren), etodolac (Lodine), indomethacin (Indocin), naproxen (Aleve, Naprosyn), meloxicam (Mobic), piroxicam (Feldene), and others; or salicylates such as aspirin, Disalcid, Doan's Pills, Dolobid, Salflex, Tricosal, and others.
This may not be comprehensive list and there may be other drugs that can interact with Methotrexate. Inform your doctor about all your current prescription and over-the-counter medications. These should include vitamins, minerals, herbal products, and drugs prescribed by other medical professionals. Avoid the consumption of a new medication without informing your doctor.
Methotrexate and Pregnancy:
Methotrexate is known to be contraindicated in pregnant women suffering from psoriasis or rheumatoid arthritis. Methotrexate should be used in the treatment of cancer in pregnant woman only when the potential benefit is much greater than the risk to the fetus.
Women should avoid starting a family if either partner is undergoing a medication course of Methotrexate. Male patients should avoid family plans during and for a minimum of three months after therapy while female patients should avoid pregnancy during and for at least one ovulatory cycle after therapy.
Patients with inflammatory conditions such as psoriasis or rheumatoid arthritis along with alcoholism
, alcoholic liver disease or other chronic liver disease should not consume Methotrexate tablets. Patients with psoriasis or rheumatoid arthritis who are known to have immunodeficiency syndromes should not be administered Methotrexate. Patients with psoriasis or rheumatoid arthritis who have had prior blood dyscrasias, such as bone marrow hypoplasia, leukopenia, thrombocytopenia or significant anemia, should not consume Methotrexate.
Methotrexate is contraindicated in lactating mothers because of its severe and dangerous effects in breast fed infants. Methotrexate can be transmitted through breast milk and could result in serious problems in a nursing infant. Breast feeding mothers should consult their doctor before taking Neotrexate tablets.
Patients with a known hypersensitivity to Methotrexate or any other inactive ingredient present in Neotrexate tablets should not take the drug.
General Effects
Methotrexate can reduce the number of blood cells that protect you from infections and aids in blood clotting. This may result in increased vulnerability to infection or bleeding. Let your doctor know if you develop any uncommon bruising or bleeding, or symptoms of infection (fever, chills, body aches).
Methotrexate And Alcohol:
Avoid the consumption of alcohol during the course of Methotrexate medication. Hepatotoxicity (Liver Damage) was perceived to be related to the total cumulative dose and appeared to be increased by alcoholism.
Alcohol drinks, including beer and wine, may increase some of the side effects with Methotrexate including the possibility of liver damage.
General Precautions
All patients administered Neotrexate tablets must be carefully and frequently examined. This may include complete blood counts, blood tests to investigate liver and kidney function, chest x-rays, and liver biopsies. Patients undergoing a course of Methotrexate tablets should avoid sunlight or artificial UV rays exposure from sunlamps or tanning beds. This is especially important for psoriasis patients because Methotrexate makes skin more vulnerable to sunlight and the psoriasis condition may further deteriorate.

Side Effects of Methotrexate Tablets(Neotrexate)

The administration of Methotrexate tablets are known to have certain side effects. Consult your doctor if you develop any of these side effects: dizziness, drowsiness, headache, swollen, tender gums, loss of appetite, reddened eyes, and hair loss.
Inform your doctor straightaway if you develop serious symptoms such as dry cough, difficulty in breathing, blurred vision or sudden loss of vision, diarrhea, blood in urine or stools, darkening of urine, clay-colored stools, yellowing of skin and whites of eyes, irregularities in urination pattern, seizures, confusion, weakness or difficulty moving one or both sides of the body, loss of consciousness, white patches or sores inside your mouth or on your lips, sore throat, bleeding gums.
Some of the common side effects of Methotrexate administration are ulcerative stomatitis, low white blood cell count resulting in susceptibility to infection, vomiting, abdominal pain, tiredness, chills, fever, body aches, light-headedness and seldom pulmonary fibrosis.
This is not an exhaustive list of all the possible side effects from the administration of Neotrexate (Methotrexate tablets). If you develop any other symptoms apart from those mentioned in the list, please inform your doctor immediately.

Methotrexate Tablets (Neotrexate) During Pregnancy

Methotrexate Tablets (Neotrexate) has been classified by the US FDA as Pregnancy Category X.
Methotrexate Tablets are contraindicated in pregnant women with non-neoplastic diseases.
Based on published reports and its mechanism of action, Methotrexate can cause embryo-fetal toxicity and fetal death when administered to a pregnant woman. There are no animal data that meet current standards for nonclinical developmental toxicity studies. Advise pregnant women with neoplastic diseases of the potential risk to a fetus.
Do not use this medicine without your doctor's consent in case you are pregnant. Stop using this medication and inform your doctor immediately if you become pregnant during treatment.

Buy Methotrexate 2.5 mg Tablets (Neotrexate Pills ) Online at Only $0.5 per Pill

You can buy Methotrexate 2.5 mg tablets online from Everest Online Pharmacy at a cheap price. Neotrexate 2.5 mg pills, manufactured by GlaxoSmithKline, India are supplied in a blister strip of 10 tablets. It is available in packs of 30, 60, 90, 180 and 360 tablets. The cost of a single 2.5 mg pill of is 0.5 USD when you place an order for 360 tablets.

Disclaimer

The above information is provided to the best of our knowledge and in good faith. It is without a warrant of any kind, expressed or implied.

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