Letrozole Tablets

Generic Letrozole (Letromina Tablets) - Product Information

Generic Letrozole (Letromina Tablets) is used to treat certain types of breast cancer in women who have already stopped menstruating (postmenopausal). It is also used for women who have already had other cancer treatments (eg, Tamoxifen).
Letrozole is also used off-label to treat infertility, particularly for inducing ovulation in women with polycystic ovary syndrome (PCOS).
Tamodex tablets are manufactured by Cadila Healthcare Limited, India, in the strengths of 10 mg and 20 mg.
We also have in stock Tamodex (Tamoxifen Citrate tablets) which is commonly used to treat certain types of breast cancer. It is also used to lower the risk of invasive breast cancer and prevent some breast cancers from recurring.

Name of the Drug

Letromina Tablets.

Manufacturer of Letromina Tablets

Alpha Pharma Healthcare Private limited, India.  
Website: www.alpha-pharma.com

Active Pharmaceutical Ingredient

The active ingredient present in Letromina tablets is Letrozole. Each tablet of Letromina contains 2.5 mg Letrozole.

Uses of Generic Letrozole Tablets (Letromina Tablets)

Letrozole (Letromina Tablets) is an aromatase inhibitor indicated for:
• Adjuvant treatment of postmenopausal women with hormone receptor positive early breast cancer.
• Extended adjuvant treatment of postmenopausal women with early breast cancer who have received prior standard adjuvant tamoxifen therapy.
• First and second-line treatment of postmenopausal women with hormone receptor positive or unknown advanced breast cancer

Generic Letrozole Tablets (Letromina Tablets) - Dosage

Generic Letrozole tablets should be administered exactly as suggested by your doctor. Your doctor may recommend a dosage of Letromina tablets depending on your age, medical requirement, body weight, other medical conditions, and current medications.
Letromina tablets are taken orally without regard to meals.
The recommended dose: 2.5 mg once daily. Patients with cirrhosis or severe hepatic impairment: 2.5 mg every other day.
Letromina tablets work effectively if the amount of Letrozole is maintained at a constant level in the body. You should be systematic about the daily schedule for the medication such that you take tablets at about the same time every day, to get the maximum benefit of the medication. Continue taking Letromina tablets without missing any doses for the recommended treatment period and do not stop the treatment suddenly even if you feel better.
Please consult your doctor for exact dosing instructions.Letromina tablets (Generic Letrozole tablets) should be administered in the dose prescribed by the doctor and for the duration recommended by the doctor.

Missed Dose

If you forget to take your regular tablet dose on time, take it whenever you remember.
If you remember the next day, skip the missed dose and take your scheduled dose. Do not take a double dose to compensate the missed dose.

Letrozole (Letromina Tablets) Mechanism of Action

Letrozole tablets work by inhibiting the aromatase enzyme, which stops the conversion of androgens (like testosterone) into estrogens. This leads to a decrease in estrogen levels in the body.
Blocks cancer cell growth:
For estrogen-sensitive breast cancers, letrozole works by decreasing the amount of estrogen the body produces. This slows or stops the growth and spread of cancer cells, which are often stimulated by estrogen.
Targeting peripheral tissue:
Letrozole also acts on peripheral tissues and breast tumors that can produce their own estrogens, making it an effective treatment for postmenopausal women.

Storage Instructions for Letromina Tablets (Generic Letrozole Tablets)

Store Letromina tablets at controlled room temperature (20°C to 25°C),protected from heat, moisture, and sunlight. Excursions are permitted from 15°C to 30°C.
Retain the original packing of the medication and do not consume past its expiration date printed on the blister pack. Keep the pack of Generic Letrozole tablets away from the reach of children and pets. Do not dispose Letromina tablets along with domestic waste or sewage. Consult your doctor or pharmacist about the correct method of disposal.

Contraindications

Letromina tablets are contraindicated in patients with a hypersensitivity to Letrozole or any inactive ingredient present in tablets. Letromina tablets are also contraindicated in the following cases:
Women of premenopausal endocrine status, including pregnant women

Overdose

Isolated cases of Letrozole Tablets (Letromina Tablets) overdose have been reported. In these instances, the highest single dose ingested was 62.5 mg or 25 tablets. While no serious adverse reactions were reported in these cases, because of the limited data available, no firm recommendations for treatment can be made.
However, emesis could be induced if the patient is alert. In general, supportive care and frequent monitoring of vital signs are also appropriate.

Warnings and Precautions

Bone Effects:
Use of Letrozole may cause decreases in bone mineral density (BMD). Consideration should be given to monitoring BMD.
Cholesterol:
Consideration should be given to monitoring serum cholesterol. In the adjuvant trial (BIG 1-98), hypercholesterolemia was reported in 52.3% of letrozole patients and 28.6% of tamoxifen patients. Grade 3 to 4 hypercholesterolemia was reported in 0.4% of Letrozole patients and 0.1% of Tamoxifen patients.
Hepatic Impairment:
Subjects with cirrhosis and severe hepatic impairment who were dosed with 2.5 mg of Letrozole experienced approximately twice the exposure to letrozole as healthy volunteers with normal liver function. Therefore, a dose reduction is recommended for this patient population.
Fatigue and Dizziness:
Because fatigue, dizziness, and somnolence have been reported with the use of letrozole, caution is advised when driving or using machinery until it is known how the patient reacts to letrozole use.
Laboratory Test Abnormalities:
No dose-related effect of letrozole on any hematologic or clinical chemistry parameter was evident. Moderate decreases in lymphocyte counts, of uncertain clinical significance, were observed in some patients receiving Letrozole tablets 2.5 mg. This depression was transient in about half of those affected.
Embryo-Fetal Toxicity:
Based on post-marketing reports, findings from animal studies and the mechanism of action, letrozole can cause fetal harm and is contraindicated for use in pregnant women. In post-marketing reports, use of letrozole during pregnancy resulted in cases of spontaneous abortions and congenital birth defects.

Side Effects of Letrozole Tablets (Letromina Tablets)

The most common Letrozole tablets (Letromina tablets) side effects with an incidence rate of 20% or greater were hot flashes, arthralgia, flushing, asthenia, edema, arthralgia, headache, dizziness, hypercholesterolemia, sweating increased, bone pain, and musculoskeletal.

Letrozole Tablets During Pregnancy

Letrozole tablets (Letromina tablets) has been classified by the US FDA as Pregnancy Category D.
Based on post-marketing reports, findings from animal studies and the mechanism of action, letrozole can cause fetal harm and is contraindicated for use in pregnant women. In post-marketing reports, use of letrozole during pregnancy resulted in cases of spontaneous abortions and congenital birth defects; however, the data are insufficient to inform a drug-associated risk.
In animal reproduction studies, administration of letrozole to pregnant animals during organogenesis resulted in increased post-implantation pregnancy loss and resorption, fewer live fetuses, and fetal malformation affecting the renal and skeletal systems in rats and rabbits at doses approximately 0.1 times the daily maximum recommended human dose (MRHD) on a mg/m 2 basis.
Do not use this medicine without your doctor's consent in case you are pregnant. Stop using this medication and inform your doctor immediately if you become pregnant during treatment.

Nursing Considerations

It is not known if Letrozole is present in human milk. There are no data on the effects of letrozole on the breastfed infant or milk production. Exposure of lactating rats to letrozole was associated with impaired reproductive performance of the male offspring.
Do not use Letromina tablets without telling your doctor if you are breast-feeding a baby.

Buy Generic Letrozole 2.5 mg Pills Online From Only $0.83 per Pill

You can buy Generic Letrozole Tablets online from Everest Online Pharmacy at a cheap price. Letromina 2.5 mg pills, manufactured by Alpha Pharma Healthcare Private limited, India, are supplied in a blister strip of 10 tablets. The mg tablets cost only $0.83 per unit when you place an order for 420 tablets.

Disclaimer

The above information is provided to the best of our knowledge and in good faith. It is without a warrant of any kind, expressed or implied.

>

Shipping Restriction