Ezetimibe Tablets

Ezedoc Tablets (Generic Ezetimibe) - Product Information

Ezedoc (Generic Ezetimibe tablets) is used alone or combination with diet and other cholesterol-lowering medicines (eg, fenofibrate, statins) to treat high cholesterol and triglyceride (fats) levels in the blood, in patients with heterozygous familial hypercholesterolemia (HeFH), homozygous familial hypercholesterolemia (HoFH), or homozygous familial sitosterolemia.
Ezetimibe may also be used for other conditions as determined by your healthcare provider.
We also have in stock Atorvastatin Calcium Tablets (Lipvas 10 mg 20 mg and 40 mg) which is also used together with a proper diet to lower cholesterol and triglyceride (fats) levels in the blood.

Name of the Drug

Ezedoc tablets.

Manufacturer of Ezedoc Tablets

Lupin Limited, India  
Website: www.lupin.com

Active Pharmaceutical Ingredient

The active ingredient present in Ezedoc tablets is Ezetimibe. Each Ezedoc tablet contains 10 mg of Ezetimibe.

Uses of Ezetimibe (Ezedoc Tablets)

Primary Hypercholesterolaemia
Ezetimibe, co-administered with an HMG-CoA reductase inhibitor (statin) is indicated as adjunctive therapy to diet for use in patients with primary (heterozygous familial and non-familial) hypercholesterolaemia who are not appropriately controlled with a statin alone. Ezetimibe monotherapy is indicated as adjunctive therapy to diet for use in patients with primary (heterozygous familial and nonfamilial) hypercholesterolaemia in whom a statin is considered inappropriate or is not tolerated.
Prevention of Cardiovascular Events
Ezetimibe is indicated to reduce the risk of cardiovascular events in patients with coronary heart disease (CHD) and a history of acute coronary syndrome (ACS) when added to ongoing statin therapy or initiated concomitantly with a statin.
Homozygous Familial Hypercholesterolaemia (HoFH)
Ezetimibe co-administered with a statin, is indicated as adjunctive therapy to diet for use in patients with HoFH. Patients may also receive adjunctive treatments (e.g. LDL apheresis).
Homozygous Sitosterolaemia (phytosterolaemia)
Ezetimibe is indicated as adjunctive therapy to diet for use in patients with homozygous familial sitosterolaemia.

Ezedoc Tablets (Generic Ezetimibe) - Dosage

Generic Ezetimibe tablets should be administered exactly as suggested by your doctor. Your doctor may recommend a dosage of Ezedoc tablets depending on your age, medical requirement, body weight, other medical conditions, and current medications.
The recommended dose is one 10 mg tablet daily. Ezetimibe can be administered at any time of the day, with or without food.
When Ezetimibe is added to a statin, either the indicated usual initial dose of that particular statin or the already established higher statin dose should be continued. In this setting, the dosage instructions for that particular statin should be consulted.
Ezedoc tablets work effectively if the amount of Ezetimibe is maintained at a constant level in the body. You should be systematic about the daily schedule for the medication such that you take tablets at about the same time every day, to get the maximum benefit of the medication. Continue taking Ezedoc tablets without missing any doses for the recommended treatment period and do not stop the treatment suddenly even if you feel better.

Please consult your doctor for exact dosing instructions.Ezedoc tablets (Generic Ezetimibe tablets) should be administered in the dose prescribed by the doctor and for the duration recommended by the doctor.

Missed Dose

If you forget to take your regular Ezedoc tablet dose on time, take it whenever you remember.
If you remember the next day, skip the missed dose and take your scheduled dose. Do not take a double dose to compensate the missed dose.

Ezetimibe Mechanism of Action

Ezetimibe works by inhibiting the absorption of cholesterol in the intestines.
Reduction of cholesterol absorption leads to lower cholesterol stores in the liver, which increases the removal of cholesterol from the bloodstream.

Storage Instructions for Ezedoc Tablets (Generic Ezetimibe)

Store Ezedoc tablets at controlled room temperature (20°C to 25°C),protected from heat, moisture, and sunlight. Excursions are permitted from 15°C to 30°C.
Retain the original packing of the medication and do not consume past its expiration date printed on the blister pack. Keep the pack of Ezedoc tablets away from the reach of children and pets. Do not dispose Generic Ezetimibe tablets along with domestic waste or sewage. Consult your doctor or pharmacist about the correct method of disposal.

Contraindications

Ezedoc tablets are contraindicated in patients with a hypersensitivity to or any inactive ingredient present in tablets. Ezedoc tablets are contraindicated in the following cases:
When Ezetimibe is co-administered with a statin, please refer to the SPC for that particular medicinal product.
Therapy with Ezetimibe co-administered with a statin is contraindicated during pregnancy and lactation.
Ezetimibe co-administered with a statin is contraindicated in patients with active liver disease or unexplained persistent elevations in serum transaminases.
Women who are pregnant or may become pregnant
Nursing mothers

Overdose

In clinical studies, administration of ezetimibe, 50 mg/day to 15 healthy subjects for up to 14 days, or 40 mg/day to 18 patients with primary hyperlipidemia for up to 56 days, was generally well tolerated.
A few cases of overdosage with Ezetimibe have been reported; most have not been associated with adverse experiences. Reported adverse experiences have not been serious. In the event of an overdose, symptomatic and supportive measures should be employed.

Warnings and Precautions

Risks Associated with Combination Treatment with a Statin, Fenofibrate, or Other LDL-C Lowering Therapies:
Refer to the Prescribing Information of these products for a description of their risks including, but not limited to, the warnings and precautions.
Liver Enzyme Abnormalities and Monitoring:
Increases in serum transaminases have been reported with use of Ezetimibe . Perform liver enzyme testing as clinically indicated and consider withdrawal of Ezetimibe if increases in ALT or AST 3 X ULN or higher persist.
Skeletal Muscle Effects (e.g., Myopathy and Rhabdomyolysis):
Ezetimibe may cause myopathy and rhabdomyolysis. In post-marketing reports, most patients who developed rhabdomyolysis were taking a statin or other agents known to be associated with an increased risk of rhabdomyolysis, such as fibrates. If myopathy is suspected, discontinue Ezetimibe and other concomitant medications, as appropriate
Moderate Or Severe Hepatic Impairment:
Ezetimibe is not recommended in patients with moderate or severe hepatic impairment.

Effects on ability to drive and use machines

No studies on the effects on the ability to drive and use machines have been performed. However, when driving vehicles or operating machines, it should be taken into account that dizziness has been reported.

Side Effects of Ezetimibe (Ezedoc Tablets)

Common Ezetimibe (Ezedoc Tablets) side effects observed in clinical trials:
Ezetimibe Tablets administered alone (incidence rate of 2% or higher and greater than placebo): upper respiratory tract infection, diarrhea, arthralgia, sinusitis, pain in extremity, fatigue, and influenza.
Ezetimibe coadministered with a statin (incidence rate of 2% or higher and greater than statin alone): nasopharyngitis, myalgia, upper respiratory tract infection, arthralgia, diarrhea, back pain, influenza, pain in extremity, and fatigue.
The following additional adverse reactions have been identified during post-approval use of Ezetimibe (Ezedoc Tablets):

• Blood Disorders: thrombocytopenia
• Gastrointestinal Disorders: abdominal pain; pancreatitis; nausea
• Hepatobiliary Disorders: elevations in liver transaminases; hepatitis; cholelithiasis; cholecystitis
• Immune System Disorders: Hypersensitivity reactions including: anaphylaxis, angioedema, rash, and urticaria
• Musculoskeletal Disorders: elevated creatine phosphokinase; myopathy/rhabdomyolysis
• Nervous System Disorders: dizziness; paresthesia; depression; headache
• Skin and Subcutaneous Tissue Disorders: erythema multiforme

Ezetimibe During Pregnancy

Ezetimibe has been classified by the US FDA as Pregnancy Category C.
Ezetimibe should be given to pregnant women only if clearly necessary.
No clinical data are available on the use of ezetimibe during pregnancy. Animal studies on the use of ezetimibe in monotherapy have shown no evidence of direct or indirect harmful effects on pregnancy, embryofoetal development, birth or postnatal development.
Do not use this medicine without your doctor's consent in case you are pregnant. Stop using this medication and inform your doctor immediately if you become pregnant during treatment.

Nursing Considerations

There is no information about the presence of Ezetimibe in human milk. Ezetimibe is present in rat milk. When a drug is present in animal milk, it is likely that the drug will be present in human milk.
There is no information about the effects of Ezetimibe on the breastfed infant or the effects of ezetimibe on milk production. Ezetimibe (Ezedoc Tablets) should not be used in nursing mothers unless the potential benefit justifies the potential risk to the infant.
Do not use this medication without telling your doctor if you are breast-feeding a baby.

Buy Generic Ezetimibe 10 mg Pills Online From Only $0.72 per Pill

You can buy Generic Ezetimibe tablets online from Everest Online Pharmacy at a cheap price. Ezedoc 10 mg pills, manufactured by Lupin Limited, India, are supplied in a blister strip of 10 tablets. The 10 mg tablets cost only $0.72 per unit when you place an order for 240 tablets.

Disclaimer

The above information is provided to the best of our knowledge and in good faith. It is without a warrant of any kind, expressed or implied.

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