Cenforce Tablets

Cenforce Tablets (Generic Sildenafil Citrate) - Product Information

Cenforce (Generic Sildenafil Citrate) is an oral medication recommended to treat adult men with erectile dysfunction, which is the inability to achieve or maintain a penile erection sufficient for satisfactory sexual performance. In order for Sildenafil to be effective, sexual stimulation is required.
Cenforce tablets, which contain Sildenafil Citrate as the active ingredient, belongs to a group of medications known as Phosphodiesterase type-5 inhibitors. It acts by inhibiting cGMP-specific phosphodiesterase type 5, an enzyme that delays degradation of cGMP, which regulates blood flow in the penis.
The therapeutic effect of Cenforce pills is visible within 30 minutes to one hour of consumption and it lasts for a duration of 3 to 4 hours. However, Cenforce tablets may take longer to start working if you take it with a heavy meal.
Cenforce tablets should not be consumed by women or any person under the age of 18 years. Cenforce tablets are available in the strength of 25 mg, 50 mg and 100 mg of Sildenafil.
We also have in stock Kamagra Oral Jelly (Sildenafil Jelly) which is used an oral therapy for erectile dysfunction (male impotence) and works efficaciously to relax the muscles in the penile area, thus enhancing blood flow in the penis during sexual activity.

Name of the Drug

Cenforce tablets.
Generic Sildenafil Citrate tablets are also available under different brand names such as Kamagra, Kamagra Soft Chewable, Silagra, Alphagra, Red Serpent (Sildenafil 120 mg), Rocketman, Penegra, Caverta or Suhagra tablets.

Manufacturer of Cenforce Tablets

Centurion Remedies Private Limited, India  
Website: www.centurionremedies.com

Active Pharmaceutical Ingredient

The active ingredient present in Cenforce tablets is Sildenafil Citrate. Each Cenforce tablet contains Sildenafil Citrate equivalent to 25 mg, 50 mg or 100 mg of Sildenafil.

What are Cenforce Tablets Used For?

Cenforce tablets (Generic Sildenafil citrate), manufactured by Centurion Remedies Private Limited, India, in the strengths of 25 mg, 50 mg and 100 mg of Sildenafil Citrate, are oral drugs recommended for men for the treatment of erectile dysfunction(also called sexual impotence), a medical condition due to which men are unable to experience a lasting erection during sexual activity. They are also used to treat pulmonary arterial hypertension (PAH). Sildenafil belongs to a group of medicines called phosphodiesterase 5 (PDE5) inhibitors. These medicines prevent an enzyme called phosphodiesterase type-5 from working too quickly. The penis is one of the areas where this enzyme works.
Sildenafil is also used in both men and women to treat the symptoms of pulmonary arterial hypertension. This is a type of high blood pressure that occurs between the heart and the lungs. When hypertension occurs in the lungs, the heart must work harder to pump enough blood through the lungs. Sildenafil works on the PDE5 enzyme in the lungs to relax the blood vessels. This will increase the supply of blood to the lungs and reduce the workload of the heart.
The therapeutic effect of Cenforce tablets is visible within 30 minutes to one hour of consumption and it lasts for a duration of approximately 3 to 4 hours. Cenforce pills are not effective against the prevention of pregnancy or against sexually transmitted diseases (such as HIV, hepatitis B, gonorrhea, and syphilis). For these purposes, you should practice proper and safe barrier methods of contraception such as condoms.

Cenforce Tablets Dosage - How to Take Sildenafil Citrate Tablets?

Cenforce tablets should be used exactly as prescribed by your doctor. Your doctor may suggest a dosage of Cenforce tablets depending on your requirement, body weight, other medical conditions, and current medications. Cenforce pills can be consumed before or after meals.
For most patients, the recommended dose is 50 mg taken, as needed, approximately 1 hour before sexual activity. However, Sildenafil tablets may be taken anywhere from 30 minutes to 4 hours before sexual activity. The maximum recommended dosing frequency is once per day. 24 hours must elapse before taking your next dose. Based on effectiveness and toleration, the dose may be increased to a maximum recommended dose of 100 mg or decreased to 25 mg.
Cenforce tablets will take longer to produce the medical effects if you have eaten a large or high-fat meal before consuming the medication. The incidence of an erection requires sexual stimulation after taking Cenforce pills. Patients should consume only one Cenforce tablet in a day.

Please consult your doctor for exact dosing instructions. Cenforce Tablets (Generic Sildenafil Citrate) should be administered in the dose prescribed by the doctor and for the duration recommended by the doctor.

Missed Dose

Cenforce tablets are consumed on a need-basis before engaging in sexual activity. Patients should consume only one Cenforce tablet in a day.
Do not administer more than a single dose of Cenforce tablets within a duration of 24 hours. The question of missed dose does not arise in this case.

Sildenafil Citrate Mechanism of Action – How Does Cenforce Work?

Erectile dysfunction in men is the failure to develop or maintain a good erection upon sexual stimulation. This malfunction occurs due to the narrowing of the blood vessels in the penis.
The physiologic mechanism of erection of the penis involves release of nitric oxide (NO) in the corpus cavernosum during sexual stimulation. NO then activates the enzyme guanylate cyclase, which results in increased levels of cyclic guanosine monophosphate (cGMP), producing smooth muscle relaxation in the corpus cavernosum and allowing inflow of blood.
Sildenafil enhances the effect of NO by inhibiting phosphodiesterase type 5 (PDE5), which is responsible for degradation of cGMP in the corpus cavernosum. Sildenafil has no direct relaxant effect on isolated human corpus cavernosum. When sexual stimulation causes local release of NO, inhibition of PDE5 by Sildenafil causes increased levels of cGMP in the corpus cavernosum, resulting in smooth muscle relaxation and inflow of blood to the corpus cavernosum. Sildenafil at recommended doses has no effect in the absence of sexual stimulation.

Storage

Store Cenforce tablets at controlled room temperature (20°C to 25°C). Excursions are permitted from 15°C to 30°C.
Keep the pack of Cenforce tablets protected from heat, moisture, and sunlight. Retain the original packing of the medication and do not consume Cenforce tablets past its expiration date printed on the blister pack. Keep the pack of Cenforce tablets away from the reach of children and pets. Do not dispose Cenforce tablets along with domestic waste or sewage.
Consult your doctor or pharmacist about the correct method of disposal.

Contraindications

Cenforce tablets are contraindicated in patients with a known hypersensitivity to Sildenafil Citrate or any inactive ingredient present in Cenforce tablets.
Cenforce tablets are also contraindicated in patients with the following conditions:
Administration of Cenforce to patients using nitric oxide donors, such as organic nitrates or organic nitrites in any form. VIAGRA was shown to potentiate the hypotensive effect of nitrates.
Administration with Guanylate Cyclase (GC) stimulators, such as Riociguat.
Cenforce (Sildenafil Citrate tablets) should not be used in men for whom sexual activity is inadvisable (e.g. patients with severe cardiovascular disorders such as unstable angina or severe cardiac failure).
Sildenafil is contraindicated in patients who have loss of vision in one eye because of non-arteritic anterior ischaemic optic neuropathy (NAION), regardless of whether this episode was in connection or not with previous PDE5 inhibitor exposure.

Overdose

In studies with healthy volunteers of single doses of Sildenafil (Cenforce tablets) up to 800 mg, adverse reactions were similar to those seen at lower doses but incidence rates and severities were increased.
In cases of overdose, standard supportive measures should be adopted as required. Renal dialysis is not expected to accelerate clearance as sildenafil is highly bound to plasma proteins and it is not eliminated in the urine.

Warnings and Precautions to be taken when using Cenforce Tablets

Medical History
Before beginning a course of Cenforce tablets, discuss your personal and family medical history with your doctor. Inform your doctor if you have had heart problems (heart attack, irregular heartbeat, angina, chest pain, narrowing of the aortic valve or heart failure, heart surgery, stroke, low or high blood pressure), a severe loss of body water (dehydration), kidney or liver disorders, penis conditions (such as angulation, fibrosis/scarring, Peyronie's disease), history of painful/prolonged erection (priapism), conditions that may increase the risk of priapism (such as sickle cell anemia, leukemia, multiple myeloma), eye problems (such as retinitis pigmentosa, sudden decreased vision, NAION), bleeding disorders (hemophilia), active stomach ulcers.
Cardiovascular Risk Factors
Prior to initiating any treatment for erectile dysfunction, physicians should consider the cardiovascular status of their patients, since there is a degree of cardiac risk associated with sexual activity. Sildenafil has vasodilator properties, resulting in mild and transient decreases in blood pressure
Priapism
Agents for the treatment of erectile dysfunction, including Sildenafil, should be used with caution in patients with anatomical deformation of the penis (such as angulation, cavernosal fibrosis or Peyronie's disease), or in patients who have conditions which may predispose them to priapism (such as sickle cell anaemia, multiple myeloma or leukaemia). Patients should seek emergency treatment if an erection lasts for more than 4 hours.
Effects on the Eye
Physicians should advise patients to stop use of all phosphodiesterase type 5 (PDE5) inhibitors, including Sildenafil tablets, and seek medical attention in the event of a sudden loss of vision in one or both eyes. Such an event may be a sign of non-arteritic anterior ischemic optic neuropathy (NAION), a rare condition and a cause of decreased vision including permanent loss of vision, that has been reported rarely post-marketing. Cenforce tablets should be used with caution, and only when the anticipated benefits outweigh the risks, in patients with a history of NAION. Patients with a "crowded" optic disc may also be at an increased risk of NAION.
Hearing Loss
Physicians should advise patients to stop taking PDE5 inhibitors, including sildenafil tablets, and seek prompt medical attention in the event of sudden decrease or loss of hearing.
Concomitant use with other PDE5 Inhibitors:
Concomitant use with other PDE5 inhibitors or other treatments for erectile dysfunction The safety and efficacy of combinations of sildenafil with other PDE5 Inhibitors, or other pulmonary arterial hypertension (PAH) treatments containing sildenafil, or other treatments for erectile dysfunction have not been studied. Therefore the use of such combinations is not recommended.
Risk of Hypotension:
Caution is advised when Cenforce is co-administered with alpha-blockers or anti-hypertensives. Concomitant use may lead to hypotension
Allergy
Please inform your doctor if you have an allergy or have had an allergic reaction in the past to Sildenafil Citrate or any inactive ingredient in Cenforce tablets.
Decreased Blood Pressure:
Decreased blood pressure, syncope, and prolonged erectionmay occur at higher sildenafil exposures. In patients taking strong CYP inhibitors, such as Ritonavir, Sildenafil exposure is increased. Decrease in Cenforce dosage is recommended.
Cenforce Interactions
Before staring the course of Cenforce tablets, please inform your doctor of all your current medications including prescription drugs, over the counter medications, mineral supplements, herbal products, and vitamins. Cenforce tablets are known to have drug interactions with certain other medications. Let your doctor know if are using nitroglycerin (Nitrostat, Nitrolingual, Nitro-Dur, Nitro-Bid), isosorbide dinitrate (Dilatrate-SR, Isordil, Sorbitrate), and isosorbide mononitrate (Imdur, ISMO, Monoket), recreational drugs called "poppers" containing amyl or butyl nitrite, alpha blocker medication (such as doxazosin, tamsulosin), azole antifungals (such as itraconazole, ketoconazole), macrolide antibiotics (such as clarithromycin, erythromycin), HIV protease inhibitors (such as ritonavir, saquinavir), hepatitis C virus protease inhibitors (such as boceprevir, telaprevir), rifampin, other erectile dysfunction or pulmonary hypertension drugs (such as tadalafil, vardenafil).
Cenforce Pills and Alcohol
Consumption of excess alcohol can reduce your ability to experience an erection. You may lose the advantage of Cenforce tablets in such situations. Alcohol consumption can also increase the risk of certain side effects.
Cenforce Tablets - Driving and Other Activities
Cenforce tablets may make you light-headed or impair your vision. Avoid activities such as driving, using machinery, or performing any activity that requires complete vigilance or perfect vision until you are sure about your safety.
Surgery and Regular Medical Tests
If you plan to have surgery or any dental procedure, inform your doctor or dentists about your course of Cenforce tablets. In case of an emergency medical treatment, please inform the practitioner about your course of Cenforce tablets and the details of your last dose.

Side Effects of Sildenafil Citrate (Cenforce Tablets)

Most common Sildenafil Citrate side effects with an incidence rate of 2% or more include headache, flushing, dyspepsia, abnormal vision, nasal congestion, back pain, myalgia, nausea, dizziness and rash. The following side effects have been reported during the course of treatment with Sildenafil Citrate Tablets (Cenforce pills):

• Cardiovascular System- flushing, chest pain or heavy feeling, pain spreading to the arm or shoulder, sweating, general ill feeling, irregular heartbeat, blood pressure changes, palpitations, angina, stroke, sudden cardiac death
• Central Nervous System- headache, nausea, dizziness, memory problems, vertigo, cerebrovascular problems, fainting or brief loss of consciousness, feeling irritable, seizures
• Skin- skin rash or rashes, hypoesthesia, toxic epidermal necrolysis.
• Eye and ENT- nasal congestion, nose bleed, dryness in the nose, abnormal vision, increased sensitivity to light, blurred vision, myopia, precipitation of glaucoma, enlargement of the pupil, visual field defect, eye pain, trouble telling blue and green colors, problems in tear production, red eye, sudden decreased vision in one or both eyes (NAION), eye or eyelid oedema, sudden decrease or loss of hearing, ringing in the ears, irritation in the eye, nasal oedema, rhinitis, throat tightness.
• Gastrointestinal System- stomach upset, indigestion, dry mouth, gastro-oesophageal reflux, vomiting, hypoesthesia in the mouth.
• Genitourinary System- painful or prolonged erection lasting 4 or more hours, blood in the urine, bleeding from the penis, blood in the semen.
• Musculoskeletal System- back pain, pain in extremities, swelling in hands/ ankles/ feet, muscle pain or tenderness.
• Hypersensitivity- rash, hives, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing, warmth or redness in face/neck/chest.
• Miscellaneous- hot flushes, feeling hot, sleepiness, tiredness, Stevens-Johnson syndrome.

Inform your doctor immediately if you experience any of these side effects. This is not a comprehensive list of all the possible side effects of Cenforce tablets. If you develop any other medical conditions during the course of treatment with Cenforce pills, please consult your doctor immediately.

Sildenafil Citrate (Cenforce Tablets) During Pregnancy and Breastfeeding

Sildenafil Citrate has been classified by the US FDA as Pregnancy Category B.
Cenforce tablets are not intended for consumption by women. There are no adequate and well-controlled studies of Sildenafil in pregnant women to inform any drug-associated risks for adverse developmental outcomes. Animal reproduction studies conducted with Sildenafil did not show adverse developmental outcomes when administered during organogenesis in rats and rabbits at oral doses up to 16 and 32 times, respectively, the maximum recommended human dose (MRHD) of 100 mg/day on a mg/m. No evidence of teratogenicity, embryotoxicity or fetotoxicity was observed in rats and rabbits which received oral doses up to 200 mg/kg/day during organogenesis.
Do not use this medicine without your doctor's consent in case you are pregnant. Stop using this medication and inform your doctor immediately if you become pregnant during treatment.
Limited data indicate that Sildenafil and its active metabolite are present in human milk. There is no information on the effects on the breastfed child, or the effects on milk production. Do not use this medication without telling your doctor if you are breast-feeding a baby.

Buy Generic Sildenafil 25 mg, 50 mg and 100 mg Pills (Cenforce Tablets) Online From Only $0.60 per Pill

You can buy Generic Sildenafil tablets online from Everest Online Pharmacy at a cheap price. Cenforce 25 mg, 50 mg and 100 mg pills, manufactured by Centurion Remedies Private Limited, India, are supplied in a box of 4 tablets. The 25 mg tablets cost only $0.60 per unit when you place an order for 500 tablets.

Disclaimer

The above information is provided to the best of our knowledge and in good faith. It is without a warrant of any kind, expressed or implied.

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