Bupropion Hydrochloride Sr Tablets

Bupron SR (Generic Bupropion Hydrochloride SR 150mg Tablets) - Product Information

Bupron SR (Generic Bupropion Hydrochloride SR 150mg Tablets) is used to treat major depressive disorder (MDD) and to prevent seasonal affective disorder (SAD), which is sometimes called autumn-winter seasonal depression.
If you are already taking medicine for depression or to help you stop smoking, discuss this with your doctor before taking bupropion. It is very important that you receive only one prescription at a time for Bupropion.
Bupron SR tablets are manufactured by Sun Pharmaceutical Industries Limited, India , in the strengths of 150 mg.
We also have in stock Arpizol (Generic Aripiprazole Tablets) which is used alone or together with other medicines to treat mental conditions such as bipolar I disorder (manic-depressive illness), major depressive disorder, and schizophrenia.

Name of the Drug

Bupron SR Tablets.

Manufacturer of Bupron SR Tablets

Sun Pharmaceutical Industries Limited, India  
Website: sunpharma.com

Active Pharmaceutical Ingredient

The active ingredient present in tablets is Bupropion Hydrochloride . Each film coated extended release Bupron SR tablet of contains 150 mg of Bupropion Hydrochloride.

Uses of Bupron SR Tablets (Generic Bupropion Hydrochloride SR Tablets)

Bupropion Hydrochloride extended-release (SR) tablets (Bupron SR) are an aminoketone antidepressant, indicated for the treatment of major depressive disorder (MDD). It is also used to treat seasonal affective disorder (SAD), and under a different formulation Bupron XL by Sun Pharma to help you quit smoking.

Bupron SR Tablets (Generic Bupropion Hydrochloride SR Tablets) - Dosage

Generic Bupropion Hydrochloride SR tablets should be administered exactly as suggested by your doctor. Your doctor may recommend a dosage of Bupron SR tablets depending on your age, medical requirement, body weight, other medical conditions, and current medications.
The usual adult target dose for Bupron SR is 300 mg/day, given as 150 mg twice daily. Initiate dosing with 150 mg/day given as a single daily dose in the morning. After 3 days of dosing, the dose may be increased to the 300-mg/day target dose, given as 150 mg twice daily. There should be an interval of at least 8 hours between successive doses. A maximum of 400 mg/day, given as 200 mg twice daily, may be considered for patients in whom no clinical improvement is noted after several weeks of treatment at 300 mg/day. To avoid high peak concentrations of Bupropion and/or its metabolites, do not exceed 200 mg in any single dose.
Bupron SR tablets work effectively if the amount of Bupropion Hydrochloride is maintained at a constant level in the body. You should be systematic about the daily schedule for the medication such that you take tablets at about the same time every day, to get the maximum benefit of the medication. Continue taking Bupropion Hydrochloride SR tablets without missing any doses for the recommended treatment period and do not stop the treatment suddenly even if you feel better.

Please consult your doctor for exact dosing instructions.Bupron SR tablets (Generic Bupropion Hydrochloride SR tablets) should be administered in the dose prescribed by the doctor and for the duration recommended by the doctor.

Missed Dose

If you forget to take your regular tablet dose on time, take it whenever you remember.
If you remember the next day, skip the missed dose and take your scheduled dose. Do not take a double dose to compensate the missed dose.

Bupropion Hydrochloride Mechanism of Action

Bupropion Hydrochloride works in the brain to increase levels of the neurotransmitters norepinephrine and dopamine by blocking their reuptake, leading to a therapeutic effect for depression. While its exact mechanism isn't fully defined, it functions as a norepinephrine-dopamine reuptake inhibitor (NDRI) and has minimal effects on serotonin.
This mechanism increases the concentration of these neurotransmitters in the synapse (the gap between neurons), which is believed to alleviate symptoms of major depressive disorder.

Storage Instructions for Bupron SR Tablets

Store Bupron SR Tablets at controlled room temperature (20°C to 25°C),protected from heat, moisture, and sunlight. Excursions are permitted from 15°C to 30°C.
Retain the original packing of the medication and do not consume Bupron SR Tablets past its expiration date printed on the blister pack. Keep the pack of away from the reach of children and pets. Do not dispose Bupron SR Tablets along with domestic waste or sewage. Consult your doctor or pharmacist about the correct method of disposal.

Contraindications

Bupron SR tablets are contraindicated in patients with a hypersensitivity to Bupropion Hydrochloride or any inactive ingredient present in tablets.Bupron SR tablets are also contraindicated in the following cases:

• Seizure disorder.
• Current or prior diagnosis of bulimia or anorexia nervosa.
• Abrupt discontinuation of alcohol, benzodiazepines, barbiturates, antiepileptic drugs.
• Monoamine Oxidase Inhibitors (MAOIs): Do not use MAOIs intended to treat psychiatric disorders with Bupron SR or within 14 days of stopping treatment with Bupron SR . Do not use Bupron SR within 14 days of stopping an MAOI intended to treat psychiatric disorders. In addition, do not start Bupron SR in a patient who is being treated with linezolid or intravenous methylene blue.

Overdose

Overdoses of up to 30 grams or more of Bupropion Hydrochloride have been reported. Seizure was reported in approximately one-third of all cases. Other serious reactions reported with overdoses of Bupropion Hydrochloride alone included hallucinations, loss of consciousness, mental status changes, sinus tachycardia, ECG changes such as conduction disturbances (including QRS prolongation) or arrhythmias, clonus, myoclonus, and hyperreflexia. Fever, muscle rigidity, rhabdomyolysis, hypotension, stupor, coma, and respiratory failure have been reported mainly when bupropion was part of multiple drug overdoses.
Although most patients recovered without sequelae, deaths associated with overdoses of Bupropion Hydrochloride alone have been reported in patients ingesting large doses of the drug. Multiple uncontrolled seizures, bradycardia, cardiac failure, and cardiac arrest prior to death were reported in these patients.
There are no known antidotes for Bupropion. In case of an overdose, provide supportive care, including close medical supervision and monitoring. Consider the possibility of multiple drug overdose. Ensure an adequate airway, oxygenation, and ventilation. Monitor cardiac rhythm and vital signs. Induction of emesis is not recommended.

Warnings and Precautions

Bupron SR Tablets (Generic Bupropion Hydrochloride SR Tablets)

Neuropsychiatric adverse events during smoking cessation:
Postmarketing reports of serious or clinically significant neuropsychiatric adverse events have included changes in mood (including depression and mania), psychosis, hallucinations, paranoia, delusions, homicidal ideation, aggression, hostility, agitation, anxiety, and panic, as well as suicidal ideation, suicide attempt, and completed suicide. Observe patients attempting to quit smoking with bupropion for the occurrence of such symptoms and instruct them to discontinue bupropion and contact a healthcare provider if they experience such adverse events.
Seizure risk:
The risk is dose-related. Can minimize risk by gradually increasing the dose and limiting daily dose to 400 mg. Discontinue if seizure occurs.
Hypertension:
Bupropion Hydrochloride extended-release (SR) tablets can increase blood pressure. Monitor blood pressure before initiating treatment and periodically during treatment.
Activation of mania/hypomania:
Screen patients for bipolar disorder and monitor for these symptoms.
Psychosis and other neuropsychiatric reactions:
Instruct patients to contact a healthcare professional if such reactions occur.
Angle-closure glaucoma:
Angle-closure glaucoma has occurred in patients with untreated anatomically narrow angles treated with antidepressants

Use with Alcohol

In postmarketing experience, there have been rare reports of adverse neuropsychiatric events or reduced alcohol tolerance in patients who were drinking alcohol during treatment with Bupropion Hydrochloride SR tablets . The consumption of alcohol during treatment with Bupropion Hydrochloride SR (Bupron SR tablets) should be minimized or avoided.

Side Effects of Bupron SR Tablets (Generic Bupropion Hydrochloride SR Tablets)

Most common side effects with an incidence rate of 5% or greater and 2% or more than placebo rate are: headache, dry mouth, nausea, insomnia, dizziness, pharyngitis, constipation, agitation, anxiety, abdominal pain, tinnitus, tremor, palpitation, myalgia, sweating, rash, and anorexia.

Bupropion Hydrochloride During Pregnancy

Bupropion Hydrochloride (Bupron SR Tablets) has been classified by the US FDA as Pregnancy Category C.
Data from epidemiological studies of pregnant women exposed to bupropion in the first trimester have not identified an increased risk of congenital malformations overall. There are risks to the mother associated with untreated depression in pregnancy (see Clinical Considerations). When Bupropion was administered to pregnant rats during organogenesis, there was no evidence of fetal malformations at doses up to approximately 11 times the maximum recommended human dose (MRHD) of 400 mg/day. When given to pregnant rabbits during organogenesis, non-dose–related increases in incidence of fetal malformations, and skeletal variations were observed at doses approximately equal to the MRHD and greater. Decreased fetal weights were seen at doses twice the MRHD and greater.
Do not use this medicine without your doctor's consent in case you are pregnant. Stop using Bupron SR tablets and inform your doctor immediately if you become pregnant during treatment.

Nursing Considerations

There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding.
Limited data from postmarketing reports have not identified a clear association of adverse reactions in the breastfed infant. The developmental and health benefits of breastfeeding should be considered along with the mother’s clinical need for Bupropion Hydrochloride extended-release (SR) tablets and any potential adverse effects on the breastfed child from Bupropion Hydrochloride extended-release (SR) tablets or from the underlying maternal condition.
Do not use Bupron SR Tablets (Bupropion Hydrochloride SR Tablets) without telling your doctor if you are breast-feeding a baby.

Buy Generic Bupropion Hydrochloride SR 150 mg Pills Online From Only $0.74 per Pill

You can buy Generic Bupropion Hydrochloride SR online from Everest Online Pharmacy at a cheap price. Bupron SR Tablets 150 mg pills, manufactured by Sun Pharmaceutical Industries Limited, India, are supplied in a blister strip of 10 tablets. The 150 mg tablets cost only $0.74 per unit when you place an order for 240 tablets.

Disclaimer

The above information is provided to the best of our knowledge and in good faith. It is without a warrant of any kind, expressed or implied.

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