Adapalene Gel

Adaferin (Generic Adapalene Gel 0.1%) - Product Information

Adaferin (Generic Adapalene Gel 0.1%) is a retinoid, indicated for the topical treatment of acne vulgaris in patients 12 years of age and older. Adapalene is commonly used to treat acne vulgaris on your skin. Adapalene may also be used for other conditions as determined by your healthcare provider. Safety and effectiveness of Adaferin Gel in children below the age of 12 have not been established.
Adaferin gel is manufactured by Galderma India Pvt. Ltd. in the strengths of 0.1%.
We also have in stock Azelaic Acid Cream (Aziderm 10% and 20% Cream) which is topically administered for the treatment of bacterial skin infection such as acne and rosacea.

Name of the Drug

Adaferin Gel .

Manufacturer of Adaferin Gel

Manufactured by Laboratories Galderma in France. Marketed by Galderma India Ltd.  
Website:www.galderma.in

Active Pharmaceutical Ingredient

The active ingredient present in Adaferin gel is Adapalene. Each gram of Adaferin Gel, 0.1% contains 1 mg adapalene in an off-white aqueous gel.

Uses of Adaferin (Generic Adapalene Gel)

Adaferin Gel (Generic Adapalene Gel) is used for the cutaneous treatment of mild to moderate acne where comedones, papules and pustules predominate. Acne of the face, chest or back is appropriate for treatment.

Adaferin (Generic Adapalene Gel) - Dosage

Generic Adapalene Gel should be administered exactly as suggested by your doctor. Your doctor may recommend a dosage of Adaferin gel depending on your age, medical requirement, body weight, other medical conditions, and current medications.
Apply a thin film of Adaferin gel, 0.1% to the entire face and any other affected areas of the skin once daily in the evening, after washing gently with a non-medicated soap. This medication is for topical use only. Not for ophthalmic, oral or intravaginal use.
How to Use:
Adults And Children 12 Years Of Age And Older:
use once daily
clean the skin gently and pat dry before applying the product
cover the entire affected area with a thin layer. For example, if your acne is on the face, apply the product to the entire face.
do not use more than one time a day. Applying more than directed will not provide faster or better results, but may worsen skin irritation.
Adaferin gel works effectively if the amount of Adapalene is maintained at a constant level in the body. You should be systematic about the daily schedule for the medication such that you take tablets at about the same time every day, to get the maximum benefit of the medication. Continue using Adaferin gel without missing any doses for the recommended treatment period and do not stop the treatment suddenly even if you feel better.
Please consult your doctor for exact dosing instructions. Adaferin gel (Generic Adapalene Gel ) should be administered in the dose prescribed by the doctor and for the duration recommended by the doctor.

Missed Dose

If you forget to administer your regular Adaferin gel dose on time, administer it whenever you remember.
If you remember the next day, skip the missed dose and administer your scheduled dose. Do not administer a double dose to compensate the missed dose.

Adapalene Gel Mechanism of Action

Adapalene changes how your skin cells grow and shed so they do not clog pores or form acne. It also helps decrease redness and swelling that happens with acne.
Adapalene acts on retinoid receptors. Biochemical and pharmacological profile studies have demonstrated that adapalene is a modulator of cellular differentiation, keratinization, and inflammatory processes all of which represent important features in the pathology of acne vulgaris.
Mechanistically, adapalene binds to specific retinoic acid nuclear receptors but does not bind to the cytosolic receptor protein. Although the exact mode of action of adapalene is unknown, it is suggested that topical adapalene normalizes the differentiation of follicular epithelial cells resulting in decreased microcomedone formation.

Storage Instructions for Adaferin (Generic Adapalene Gel)

Store Adaferin Gel at controlled room temperature (20°C to 25°C),protected from heat, moisture, and sunlight. Excursions are permitted from 15°C to 30°C.
Retain the original packing of the medication and do not use Generic Adapalene Gel past its expiration date printed on the blister pack. Keep the pack of Adaferin Gel away from the reach of children and pets. Do not dispose Adaferin Gel along with domestic waste or sewage. Consult your doctor or pharmacist about the correct method of disposal.

Contraindications

Adaferin Gel is contraindicated in patients with a hypersensitivity to Adapalene or any inactive ingredient present in Adaferin Gel.

Adaferin (Generic Adapalene Gel 0.1%) Overdose

Chronic ingestion of Adapalene Gel may lead to the same side effects as those associated with excessive oral intake of vitamin A.

Warnings and Precautions

Allergic/ Hypersensitivity Reactions
Adverse reactions including anaphylaxis angioedema, face edema, eyelid edema, lip swelling, and pruritus that sometimes required medical treatment have been reported during postmarketing use of Adapalene.
Ultraviolet Light and Environmental Exposure:
Exposure to sunlight, including sunlamps, should be minimized during use of Adapalene Gel. Patients who normally experience high levels of sun exposure, and those with inherent sensitivity to sun, should be warned to exercise caution. Use of sunscreen products and protective clothing over treated areas is recommended when exposure cannot be avoided. Weather extremes, such as wind or cold, also may be irritating to patients under treatment with Adapalene Gel.
Local Cutaneous Reactions
Cutaneous signs and symptoms such as erythema, scaling, dryness, and stinging/burning were reported with use of Adapalene Gel. These were most likely to occur during the first four weeks of treatment, were mostly mild to moderate in intensity, and usually lessened with continued use of the medication. Depending upon the severity of these side effects, patients should be instructed to either use a moisturizer, reduce the frequency of application of Adapalene Gel or discontinue use. Avoid application to cuts, abrasions, eczematous or sunburned skin. As with other retinoids, use of "waxing" as a depilatory method should be avoided on skin treated with adapalene.

Side Effects of Adapalene Gel (Adaferin Gel)

The most frequently reported Adapalene Gel (Adaferin Gel) side effects with an incidence rate of 1% or more were dry skin, skin discomfort, pruritus, desquamation, and sunburn.
The following adverse reactions have been identified during post approval use of Adapalene:
Immune system disorders: angioedema, face edema, lip swelling
Skin disorders: application site pain

Adapalene Gel (Adaferin Gel) During Pregnancy

Adapalene Gel (Adaferin Gel) has been classified by the US FDA as Pregnancy Category C.
Retinoids may cause fetal harm, when administered to pregnant women. Adapalene has been shown to be teratogenic in rats and rabbits when administered orally. There are no adequate and well-controlled studies in pregnant women. Adaferin Gel, 0.3% should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus. The safety and efficacy of Adaferin Gel, 0.1% in pregnancy has not been established.
Do not use this medicine without your doctor's consent in case you are pregnant. Stop using this medication and inform your doctor immediately if you become pregnant during treatment.

Nursing Considerations

It is not known whether adapalene is excreted in human milk. Because many drugs are excreted in human milk, caution should be exercised when Adaferin Gel, 0.1% is administered to a nursing woman
Do not use this medication without telling your doctor if you are breast-feeding a baby.

Buy Generic Adapalene Gel 0.1% Online From Only $17.40 per 15g Tube

You can buy Generic Adapalene Gel 0.1% online from Everest Online Pharmacy at a cheap price. Adaferin Gel 0.1% (Adapalene Gel), manufactured by Galderma India Pvt. Ltd. is supplied in a tube of 15 grams. The 15 gm tube of Adaferin 0.1% costs only $17.40 per unit when you place an order for 10 tubes.

Disclaimer

The above information is provided to the best of our knowledge and in good faith. It is without a warrant of any kind, expressed or implied.

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