Triamcinolone Acetonide Injectable Suspension

Kenacort Injection (Triamcinolone Acetonide Injectable Suspension) - Product Information

Kenacort 40 mg and 10 mg injection (Triamcinolone Acetonide injection) is used for systemic corticosteroid therapy in such conditions as dermatoses or generalized rheumatoid arthritis and other connective tissue disorders. It is also indicated for allergic diseases.
I.M. administration is particularly valuable in such conditions when oral corticosteroid therapy is not feasible. Triamcinolone acetonide is not an agent of choice in the treatment of adrenocortical insufficiency or the salt-losing form of the adrenogenital syndrome.
We also have in stock Methylcobalamin Injections (Nurokind Vitamin B12 Injections) which is used in the treatment of Vitamin B12 deficiency in patients suffering from medical conditions such as pernicious anemia.

Name of the Drug

Kenacort Injection.

Manufacturer of Kenacort Injection

Manufactured by: Swiss Garnier Genexiaa Sciences Pvt. Ltd., India and Marketed by Abbott Healthcare Pvt. Ltd., India  
Website: www.abbott.co.in

Active Pharmaceutical Ingredient

The active ingredient present in Kenacort Injection is Triamcinolone Acetonide. Each Kenacort injection contains 10 mg or 40 mg Triamcinolone in 1 ml injectable suspension.

Uses of Kenacort Injectable Suspension (Triamcinolone Acetonide Injection)

Kenacort Injection (Triamcinolone Acetonide Injectable Suspension, USP) is indicated as adjunctive therapy for short-term administration (to tide the patient over an acute episode or exacerbation) in acute gouty arthritis, acute and subacute bursitis, acute nonspecific tenosynovitis, epicondylitis, rheumatoid arthritis, synovitis of osteoarthritis.

Kenacort Injection (Triamcinolone Acetonide Injection) - Dosage

Generic Triamcinolone Acetonide Injectable Suspension should be administered exactly as suggested by your doctor. Your doctor may recommend a dosage of Kenacort Injection depending on your age, medical requirement, body weight, other medical conditions, and current medications.
The initial dose of Kenacort Injection may vary from 5 to 60 mg per day depending on the specific indication being treated. In situations of less severity, lower doses will be sufficient while in selected patients higher initial doses may be necessary.
Systemic:
The recommended starting dose is 60 mg, injected deeply into the gluteal muscle. Loss of fatty tissue located directly below the layer of skin may occur if the injection is not properly given. The Dosage is usually adjusted within the range of 40 mg to 80 mg, depending upon patient response and duration of relief. However, some patients can well controlled on doses as low as 20 mg or less.
Hay fever or pollen asthma:
Patients with hay fever or pollen asthma who are not responding to pollen administration and other conventional therapy may obtain a remission of symptoms lasting throughout the pollen season after a single injection of 40 mg to 100 mg.
Treatment of acute exacerbations of multiple sclerosis:
Daily doses of 160 mg of Triamcinolone Acetonide injection for a week followed by 64 mg every other day for one month are usually recommended.

Local:
Intra-articular administration:
A single local injection of Triamcinolone Acetonide is normally sufficient, but several injections may be required for adequate relief of symptoms.

Initial dose:
2.5 mg to 5 mg for smaller joints and from 5 mg to 15 mg for larger joints, depending on the specific indications being treated. For adults, doses up to 10 mg for smaller areas and up to 40 mg for larger areas have usually been enough. Single injections into several joints, up to a total of 80 mg, have been administered.
Please consult your doctor for exact dosing instructions. Kenacort Injection (Generic Triamcinolone Acetonide Injection) should be administered in the dose prescribed by the doctor and for the duration recommended by the doctor.

Missed Dose

If you forget to take your regular Kenacort injection dose on time, take it whenever you remember.
If you remember the next day, skip the missed dose and take your scheduled dose. Do not take a double dose to compensate the missed dose.

Triamcinolone Acetonide Injection Mechanism of Action – How Does Kenacort Injectable Suspension Work?

Triamcinolone Acetonide (Kenacort Tablets) is a glucocorticoid that works by binding to cytoplasmic glucocorticoid receptors, which then translocate to the cell nucleus. In the nucleus, the complex binds to glucocorticoid response elements (GREs) in target genes, suppressing the expression of pro-inflammatory proteins (like cytokines and enzymes) and increasing the expression of anti-inflammatory proteins.
This ultimately reduces inflammation by decreasing inflammatory cell migration, inhibiting the production of inflammatory mediators, and decreasing the tissue response to inflammation.

Storage Instructions for Kenacort Injection

Store Kenacort Injection at controlled room temperature (20°C to 25°C),protected from heat, moisture, and sunlight. Excursions are permitted from 15°C to 30°C.
Retain the original packing of the medication and do not use Kenacort Injection past its expiration date printed on the blister pack. Keep the pack of Kenacort Injection away from the reach of children and pets. Do not dispose this medicine along with domestic waste or sewage. Consult your doctor or pharmacist about the correct method of disposal.

Contraindications

Kenacort Injections are contraindicated in patients with a hypersensitivity to Triamcinolone Acetonide or any inactive ingredient present in Kenacort Injections. Kenacort Injections are contraindicated in the following cases:
Patients with systemic fungal infections
Intramuscular corticosteroid preparations are contraindicated for idiopathic thrombocytopenic purpura.

Overdose

The symptoms of glucocorticoid overdose may include confusion, anxiety, depression, gastrointestinal cramping or bleeding, ecchymosis, moon face, and hypertension. After long-term use, rapid withdrawal can result in acute adrenal insufficiency (which may also occur in times of stress). Cushingoid changes can result from continued use of large doses.
There is no specific treatment for acute overdose, but supportive therapy should be instituted and, if gastrointestinal bleeding occurs, it should be managed.

Warnings and Precautions

Kenacort Injection (Triamcinolone Acetonide Injection) should not be administered intravenously.
Ophthalmic effects:
May include cataracts, infections, and glaucoma. Monitor intraocular pressure.
Hypothalamic-pituitary-adrenal (HPA) axis suppression:
Hypothalamic-pituitary-adrenal (HPA) axis suppression, Cushing's syndrome and hyperglycemia: Monitor patients for these conditions and taper doses gradually.
Infections:
Increased susceptibility to new infection and increased risk of exacerbation, dissemination, or reactivation of latent infection.
Elevated blood pressure, salt and water retention, and hypokalemia:
Monitor blood pressure and sodium, potassium serum levels.
GI perforation:
Increased risk in patients with certain GI disorders.
Behavioral and mood disturbances:
May include euphoria, insomnia, mood swings, personality changes, severe depression, and psychosis.
Decreases in bone density:
Monitor bone density in patients receiving long term corticosteroid therapy.
Live or live attenuated vaccines:
Do not administer to patients receiving immunosuppressive doses of corticosteroids.
Negative effects on growth and development:
Monitor pediatric patients on long-term corticosteroid therapy.
Use in pregnancy:
Fetal harm can occur with first trimester use.
Weight gain:
May cause increased appetite.

Side Effects of Kenacort Injection (Triamcinolone Acetonide Injectable Suspension)

• General: Following administration by any route, anaphylactoid reactions, anaphylactic reactions, anaphylactic shock, aggravation or masking of infections.
• Cardiovascular: hypertension, syncope, congestive heart failure, arrhythmias, necrotizing angiitis, thromboembolism, thrombophlebitis.
• Fluid and electrolyte disturbances: sodium retention, fluid retention associated with hypertension or congestive heart failure, potassium loss which may lead to cardiac arrhythmias or ECG changes, hypokalemic alkalosis.
• Musculoskeletal: muscle weakness, fatigue, myopathy, loss of muscle mass, osteoporosis, vertebral compression fractures, delayed healing of fractures, aseptic necrosis of femoral and humeral heads, pathologic fractures of long bones, spontaneous fractures.
• Gastrointestinal: peptic ulcer with possible subsequent perforation and hemorrhage, pancreatitis, abdominal distention, ulcerative esophagitis.
• Dermatologic: impaired wound healing, thin fragile skin, petechiae and ecchymoses, facial erythema, increased sweating, purpura, striae, hirsutism, acneiform eruptions, lupus erythematosus-like lesions, hives, rash, suppressed reactions to skin tests.
• Neuropsychiatric: convulsions, increased intracranial pressure with papilledema (pseudotumor cerebri) usually after treatment, vertigo, headache, insomnia, neuritis, parasthesias, aggravation of pre-existing psychiatric conditions, depression (sometimes severe), euphoria, mood swings, psychotic symptoms, personality changes.
• Endocrine: menstrual irregularities, postmenopausal vaginal haemorrhage, development of the cushingoid state, suppression of growth in children, secondary adrenocortical and pituitary unresponsiveness, particularly in times of stress (e.g., trauma, surgery, or illness), decreased carbohydrate tolerance, manifestations of latent diabetes mellitus, increased requirements for insulin or oral hypoglycemic agents in diabetics.
• Ophthalmic: central serous chorioretinopathy, posterior subcapsular cataracts, increased intra- ocular pressure, glaucoma, exophthalmos, blurred vision, corneal perforation.
• Metabolic: hyperglycemia, glycosuria, negative nitrogen balance due to protein catabolism

Triamcinolone Acetonide Injection (Kenacort) During Pregnancy

Triamcinolone Acetonide has been classified by the US FDA as Pregnancy Category C. Corticosteroids have been observed to be teratogenic in many species when given in doses equivalent to the human dose.
Triamcinolone acetonide can cause fetal harm when administered to a pregnant woman. Human and animal studies suggest that use of corticosteroids during the first trimester of pregnancy is associated with an increased risk of orofacial clefts, intrauterine growth restriction and decreased birth weight.
If this drug is used during pregnancy, or if the patient becomes pregnant while using this drug, the patient should be apprised of the potential hazard to the fetus.
Do not use this medicine without your doctor's consent in case you are pregnant. Stop using this medication and inform your doctor immediately if you become pregnant during treatment.

Kenacort Injection - Nursing Considerations

Many corticosteroids have been shown to be teratogenic in laboratory animals at low doses.
Since adequate human reproduction studies have not been performed with corticosteroids, the use of these drugs in pregnancy, nursing mothers, or women of child-bearing potential requires that the possible benefits of the drug be weighed against the potential hazards to the mother and the embryo, fetus, or breast-fed infant.
Do not use this medication without telling your doctor if you are breast-feeding a baby.

Buy Triamcinolone Acetonide Injection (Kenacort 10 mg and 40 mg Injection) Online From Only $ per Injection

You can buy Triamcinolone Acetonide Injection online from Everest Online Pharmacy at a cheap price.Kenacort Injection 10 mg and 40 mg, manufactured by Piramal Healthcare, India are supplied in a vial (injection) of 1 ml. Kenacort 10 mg injections cost only $4.00 per unit when you place an order for 20 injections.

Disclaimer

The above information is provided to the best of our knowledge and in good faith. It is without a warrant of any kind, expressed or implied.

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