Thyronorm Tablets

Thyronorm Tablets (Generic Thyroxine Sodium Tablets) - Product Information

Thyronorm Tablets containing the active ingredient Thyroxine Sodium (Levothyroxine Sodium) are used in adult and pediatric patients, including neonates, as a replacement therapy in primary (thyroidal), secondary (pituitary), and tertiary (hypothalamic) congenital or acquired hypothyroidism. This medicine is also used to help decrease the size of enlarged thyroid glands (also called a goiter).
They are also used in adult and pediatric patients, including neonates, as an adjunct to surgery and radioiodine therapy in the management of thyrotropin-dependent well-differentiated thyroid cancer.
Thyronorm tablets are manufactured by Acme Generics Private Limited and marketed by Abbott India Limited in the strengths of 12.5 mcg, 25 mcg, 50 mcg, 62.5 mcg, 75 mcg, 88 mcg, 100 mcg, 112 mcg, 125 mcg and 150 mcg.
We also have in stock Thyro3 Tablets (Liothyronine Sodium) which is also used as oral replacement therapy for the treatment of myxedema coma in hypothyroid patients to restore the thyroid levels back to normal. Thyro3 25 mcg tablets are also useful for the treatment and prevention of goiter, an endocrine disorder which is characterized by an enlarged thyroid gland.

Name of the Drug

Thyronorm Tablets.

Manufacturer of Thyronorm Tablets

Thyronorm tablets are manufactured by Acme Generics Private Limited and marketed by Abbott India Limited  
Website: www.abbott.co.in

Active Pharmaceutical Ingredient

The active ingredient present in Thyronorm Tablets is Thyroxine Sodium. Each Thyronorm Tablet contains 12.5 mcg, 25 mcg, 50 mcg, 62.5 mcg, 75 mcg, 88 mcg, 100 mcg, 112 mcg, 125 mcg or 150 mcg of Thyroxine Sodium. Thyroxine Sodium is also known as Levothyroxine Sodium.

Uses of Thyronorm Tablets (Generic Thyroxine Sodium)

Thyronorm (Generic Thyroxine Sodium 12.5 mcg, 25 mcg, 50 mcg, 62.5 mcg, 75 mcg, 88 mcg, 100 mcg, 112 mcg, 125 mcg and 150 mcg Tablets) are indicated in pediatric and adult patients for:

• Hypothyroidism: As replacement in primary (thyroidal), secondary (pituitary), and tertiary (hypothalamic) congenital or acquired hypothyroidism.
• Pituitary Thyrotropin (Thyroid-Stimulating Hormone, TSH) suppression: As an adjunct to surgery and radioiodine therapy in the management of well-differentiated thyroid cancer.

Limitations of Use:-
Not indicated for suppression of benign thyroid nodules and nontoxic diffuse goiter in iodine-sufficient patients.
Not indicated for treatment of hypothyroidism during the recovery phase of subacute thyroiditis.

Thyronorm Tablets (Levothyroxine Sodium) - Dosage

Generic Levothyroxine Sodium tablets should be administered exactly as suggested by your doctor. Your doctor may recommend a dosage of Thyronorm tablets depending on your age, medical requirement, body weight, other medical conditions, and current medications.
Administer once daily, on an empty stomach, one-half to one hour before breakfast with a full glass of water.
Administer at least 4 hours before or after drugs that are known to interfere with absorption.
Evaluate the need for dose adjustments when regularly administering within one hour of certain foods that may affect absorption.
Starting dose depends on a variety of factors, including age, body weight,cardiovascular status, concomitant medical conditions (including pregnancy), concomitant medications, co-administered food, and the specific nature of the condition being treated. Peak therapeutic effect may not be attained for 4 to 6 weeks
Adequacy of therapy determined with periodic monitoring of TSH and/or T4 as well as clinical status.
Thyronorm tablets work effectively if the amount of Levothyroxine Sodium is maintained at a constant level in the body. You should be systematic about the daily schedule for the medication such that you take Thyronorm tablets at about the same time every day, to get the maximum benefit of the medication. Continue taking Generic Thyroxine Sodium tablets without missing any doses for the recommended treatment period and do not stop the treatment suddenly even if you feel better.

Please consult your doctor for exact dosing instructions. Thyronorm tablets (Generic Thyroxine Sodium tablets) should be administered in the dose prescribed by the doctor and for the duration recommended by the doctor.

Missed Dose

If you forget to take your regular Thyronorm tablet dose on time, take it whenever you remember.
If you remember the next day, skip the missed dose and take your scheduled dose. Do not take a double dose to compensate the missed dose.

Thyroxine Sodium Mechanism of Action – How do Thyronorm Tablets Work?

Thyroid hormones exert their physiologic actions through control of DNA transcription and protein synthesis. Triiodothyronine (T3) and L-thyroxine (T4) diffuse into the cell nucleus and bind to thyroid receptor proteins attached to DNA. This hormone nuclear receptor complex activates gene transcription and synthesis of messenger RNA and cytoplasmic proteins.
The physiological actions of thyroid hormones are produced predominantly by T3, the majority of which (approximately 80%) is derived from T4 by deiodination in peripheral tissues.

Storage Instructions for Thyronorm Tablets

Store Thyronorm Tablets (Generic Thyroxine Sodium Tablets) at controlled room temperature (20°C to 25°C),protected from heat, moisture, and sunlight. Excursions are permitted from 15°C to 30°C.
Retain the original packing of the medication and do not consume past its expiration date printed on the blister pack. Keep the pack of Thyronorm tablets away from the reach of children and pets. Do not dispose along with domestic waste or sewage. Consult your doctor or pharmacist about the correct method of disposal.

Contraindications

Thyronorm tablets are contraindicated in patients with a hypersensitivity to Thyroxine Sodium (Levothyroxine Sodium) or any inactive ingredient present in tablets. Thyronorm Tablets are contraindicated in the following cases:

• Patients with untreated subclinical thyrotoxicosis (suppressed serum TSH with normal L- Triiodothyronine/Liothyronine [T3] and L-Thyroxine/Levothyroxine [T4] levels) or overt thyrotoxicosis of any etiology.
• Patients with acute myocardial infarction.
• Patients with uncorrected/untreated adrenal insufficiency, as thyroid hormones increase tissue demands for adrenocortical hormones and may thereby precipitate acute adrenal crisis by increasing the metabolic clearance of glucocorticoids
• Pregnant women being treated with drugs for hyperthyroidism, such as methimazole and propylthiourac.

Overdose

The signs and symptoms of overdosage are those of hyperthyroidism. In addition, confusion and disorientation may occur. Cerebral embolism, seizure, shock, coma, and death have been reported. Symptoms may not necessarily be evident or may not appear until several days after ingestion.
Reduce the Thyronorm Tablets (Levothyroxine Sodium) dose or temporarily discontinued if signs or symptoms of overdosage occur. Initiate appropriate supportive treatment as dictated by the patient's medical status.

Warnings and Precautions

Cardiac Adverse Reactions in the Elderly and in Patients with Underlying Cardiovascular Disease:
Initiate liothyronine sodium at less than the full replacement dose because of the increased risk of cardiac adverse reactions, including atrial fibrillation
Myxedema coma:
Do not use oral thyroid hormone drug products to treat myxedema coma
Acute adrenal crisis in patients with concomitant adrenal insufficiency:
Treat with replacement glucocorticoids prior to initiation of liothyronine sodium treatment
Prevention of hyperthyroidism or incomplete treatment of hypothyroidism:
Proper dose titration and careful monitoring is critical to prevent the persistence of hypothyroidism or the development of hyperthyroidism
Worsening of diabetic control:
Therapy in patients with diabetes mellitus may worsen glycemic control and result in increased antidiabetic agent or insulin requirements. Carefully monitor glycemic control after starting, changing, or discontinuing thyroid hormone therapy.
Decreased bone mineral density associated with thyroid hormone over-replacement:
Over-replacement can increase bone resorption and decrease bone mineral density. Give the lowest effective dose.

Side Effects of Thyroxine Sodium Tablets (Thyronorm Tablets)

Side effects associated with Thyroxine Sodium (Levothyroxine Sodium) therapy are primarily those of hyperthyroidism due to therapeutic overdosage. They include the following:

• General: fatigue, increased appetite, weight loss, heat intolerance, fever, excessive sweating
• Central nervous system: headache, hyperactivity, nervousness, anxiety, irritability, emotional lability, insomnia
• Musculoskeletal: tremors, muscle weakness, muscle spasm
• Cardiovascular: palpitations, tachycardia, arrhythmias, increased pulse and blood pressure, heart failure, angina, myocardial infarction, cardiac arrest
• Respiratory: dyspnea
• Gastrointestinal: diarrhea, vomiting, abdominal cramps, elevations in liver function tests
• Dermatologic: hair loss, flushing, rash
• Endocrine: decreased bone mineral density
• Reproductive: menstrual irregularities, impaired fertility

Seizures have been reported rarely with the institution of levothyroxine therapy.

Thyroxine Sodium (Levothyroxine Sodium) During Pregnancy and Breastfeeding

Thyroxine Sodium has been classified by the US FDA as Pregnancy Category A.
The clinical experience, including data from postmarketing studies, in pregnant women treated with oral levothyroxine to maintain euthyroid state have not reported increased rates of major birth defects, miscarriages, or other adverse maternal or fetal outcomes. There are risks to the mother and fetus associated with untreated hypothyroidism in pregnancy. Since TSH levels may increase during pregnancy, TSH should be monitored and levothyroxine sodium dosage adjusted during pregnancy.
Animal reproductive studies have not been conducted with levothyroxine sodium. Levothyroxine sodium should not be discontinued during pregnancy and hypothyroidism diagnosed during pregnancy should be promptly treated.
Published studies report that Thyroxine Sodium (Levothyroxine Sodium) is present in human milk following the administration of oral levothyroxine. No adverse effects on the breastfed infant have been reported and there is no information on the effects of Levothyroxine on milk production. Adequate levothyroxine treatment during lactation may normalize milk production in hypothyroid lactating mothers with low milk supply.

Buy Generic Thyroxine Sodium Tablets (Levothyroxine Sodium) Pills Online From Only $0.10 per Pill

You can buy Generic Thyroxine Sodium Tablets online from Everest Online Pharmacy at a cheap price. Thyronorm 12.5 mcg, 25 mcg, 50 mcg, 62.5 mcg, 75 mcg, 88 mcg, 100 mcg, 112 mcg, 125 mcg and 150 mcg pills, manufactured by Acme Generics Private Limited and marketed by Abbott India Limited are supplied in a bottle of 120 tablets. The 12.5 mg tablets cost only $0.10per unit when you place an order for tablets.

Disclaimer

The above information is provided to the best of our knowledge and in good faith. It is without a warrant of any kind, expressed or implied.

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