Tadali Tablets

Generic Tadalafil Tablets (Tadali) - Product Information

Generic Tadalafil Tablets (Tadali) which belongs to a group of medicines called phosphodiesterase 5 (PDE5) inhibitors is a medicine that is commonly used for the treatment of Erectile dysfunction, a condition where you have trouble getting or keeping an erection.
Tadalafil is also used to treat symptoms of benign prostatic hypertrophy (enlarged prostate) and pulmonary arterial hypertension and improve exercise capacity in men and women.
Tadali tablets are manufactured by Alpha-Pharma Healthcare, India in the strengths of 20 mg.
We also have Tadalafil tablets of 10 mg and 5 mg strength in our online pharmacy.
We also have in stock Apcalis SX Oral Jelly (Tadalafil Jelly) which is also used as an fast acting oral therapy for erectile dysfunction (male impotence) and works efficaciously to relax the muscles in the penile area.

Name of the Drug

Tadali Tablets
Tadalafil tablets are also available under other generic brand names such as Forzest, Megalis, Tadali, Tadacip, Tadalis, and Tadalista tablets.

Manufacturer of Tadali Tablets

Alpha Pharma Healthcare Private limited, India.  
Website: www.alpha-pharma.com

Active Pharmaceutical Ingredient

The active ingredient present in Tadali tablets is Tadalafil. Each tablet of Tadali contains 20 mg of Tadalafil.

Uses of Tadali Tablets

Tadalafil Tablets for Erectile Dysfunction
Tadalafil is used to treat men who have erectile dysfunction (also called sexual impotence). Tadalafil belongs to a group of medicines called phosphodiesterase 5 (PDE5) inhibitors. Erectile dysfunction is a condition where the penis does not harden and expand when a man is sexually excited, or when he cannot keep an erection. When a man is sexually stimulated, his body's normal response is to increase blood flow to his penis to produce an erection. By controlling the enzyme, tadalafil helps to maintain an erection after the penis is stroked by increasing blood flow to the penis. Without physical action to the penis, such as that occurring during sexual intercourse, Tadalafil will not work to cause an erection. The effects of Tadalafil tablets can last up to 36 hours.
Tadalafil Tablets for Benign Prostatic Hyperplasia (BPH)
Tadalafil tablets are also used for the treatment of medical conditions that arise due to the development of an enlarged prostate (also known as benign prostatic hyperplasia-BPH) such as difficulty in beginning urine flow, weak urine stream, frequent or urgent urination (such as during the middle of the night). Tadalafil tablets are known to treat these symptoms by relaxing effect on the smooth muscles of the prostate and bladder.
Tadalafil Tablets for Pulmonary Arterial Hypertension (PAH)
Tadalafil tablets also enhance the physical stamina in pulmonary arterial hypertension (PAH) patients. Tadalafil treats PAH by its relaxing action on the blood vessels in the lungs, resulting in improved blood flow and better energy levels.
Tadalafil tablets are not contraceptives and does not protect against sexually transmitted diseases (HIV, hepatitis B, gonorrhea, syphilis). Use proper contraceptive methods (latex condoms) for "safe sex".

Tadalafil Tablets (Tadali) - Dosage

Generic Tadalafil tablets should be administered exactly as suggested by your doctor. Your doctor may recommend a dosage of Tadali tablets depending on your age, medical requirement, body weight, other medical conditions, and current medications.
Tadalafil Tablets for Use as Needed for Erectile Dysfunction
The recommended starting dose of Tadalafil tablets for use as needed in most patients is 10 mg, taken prior to anticipated sexual activity.
The dose may be increased to 20 mg or decreased to 5 mg, based on individual efficacy and tolerability. The maximum recommended dosing frequency is once per day in most patients.
To buy Tadalafil tablets of 10 mg and 5 mg strength click on this link. Tadalafil tablets for use as needed were shown to improve erectile function compared to placebo up to 36 hours following dosing. Therefore, when advising patients on optimal use of tadalafil tablets, this should be taken into consideration.

Tadalafil tablets for Once Daily Use for Erectile Dysfunction
The recommended starting dose of tadalafil tablets for once daily use is 2.5 mg, taken at approximately the same time every day, without regard to timing of sexual activity.
The Tadalafil tablets dose for once daily use may be increased to 5 mg, based on individual efficacy and tolerability.

Tadalafil Tablets for Once Daily Use for Benign Prostatic Hyperplasia
The recommended dose of Tadalafil tablets for once daily use is 5 mg, taken at approximately the same time every day.
When therapy for BPH is initiated with Tadalafil and Finasteride, the recommended dose of tadalafil tablets for once daily use is 5 mg, taken at approximately the same time every day for up to 26 weeks.

Tadali tablets work effectively if the amount of Tadalafil is maintained at a constant level in the body. You should be systematic about the daily schedule for the medication such that you take tablets at about the same time every day, to get the maximum benefit of the medication. Continue taking Tadali tablets without missing any doses for the recommended treatment period and do not stop the treatment suddenly even if you feel better.

Please consult your doctor for exact dosing instructions. Tadali tablets (Generic Tadalafil tablets) should be administered in the dose prescribed by the doctor and for the duration recommended by the doctor.

Missed Dose

Tadalafil tablets are consumed on a need-basis before engaging in sexual activity. However, doctors recommend a regular daily dose of Tadalafil tablets for certain medical conditions.
If you forget to take dose of Tadali tablets during the course of a regular schedule, take it as soon as you remember. If the time for the next dose is near, skip the missed dose and continue your standard dosing schedule. Do not administer a double dose in a single day to compensate the missed dose.

Tadalafil Mechanism of Action – How Do Tadali Tablets Work?

Tadalafil works by inhibiting the enzyme phosphodiesterase type 5 (PDE5), which increases the levels of cyclic guanosine monophosphate (cGMP). This leads to the relaxation of smooth muscle and enhanced blood flow in specific tissues. Step-by-Step Mechanism of Action
Nitric oxide (NO) release: The process begins with stimulation, such as sexual arousal, which triggers the release of nitric oxide from nerves and blood vessels.
Increased cGMP production: The presence of NO stimulates an enzyme called guanylate cyclase, which converts guanosine triphosphate (GTP) into cyclic guanosine monophosphate (cGMP).
Smooth muscle relaxation: The increased levels of cGMP cause the smooth muscles in the walls of blood vessels to relax. This promotes vasodilation, or the widening of the blood vessels.
PDE5 inhibition by Tadalafil: Tadalafil inhibits PDE5, the enzyme that typically breaks down cGMP. By blocking PDE5, tadalafil allows cGMP levels to remain elevated for a longer period.
Prolonged smooth muscle relaxation and blood flow: The sustained high levels of cGMP lead to prolonged smooth muscle relaxation and enhanced blood flow to specific areas, such as the corpus cavernosum in the penis
Therapeutic effects based on the mechanism
This mechanism of action accounts for tadalafil's effectiveness in treating several conditions:
Erectile dysfunction (ED): In the penis, the relaxation of smooth muscles and increased blood flow result in an erection.
Pulmonary arterial hypertension (PAH): In the lungs, the vasodilation of pulmonary blood vessels reduces arterial pressure, easing the symptoms of PAH and improving exercise ability.
Benign prostatic hyperplasia (BPH): Tadalafil can relax the smooth muscles in the prostate and bladder, improving urinary flow and alleviating symptoms of BPH

Storage Instructions for Tadalafil Tablets (Tadali)

Store Tadali tablets (Generic Tadalafil) at controlled room temperature (20°C to 25°C),protected from heat, moisture, and sunlight. Excursions are permitted from 15°C to 30°C.
Retain the original packing of the medication and do not consume Tadali tablets past its expiration date printed on the blister pack. Keep the pack of away from the reach of children and pets. Do not dispose along with domestic waste or sewage. Consult your doctor or pharmacist about the correct method of disposal.

Contraindications

Tadali tablets are contraindicated in patients with a hypersensitivity to Tadalafil or any inactive ingredient present in Tadali tablets. Tadali tablets are contraindicated in the following cases:
Administration of Tadali to patients using any form of organic nitrate is contraindicated. Tadali was shown to potentiate the hypotensive effect of nitrates
Tadali tablets are also contraindicated in men with cardiac disease for whom sexual activity is inadvisable; recent MI (within 90 days) or stroke (within last 6 months), hypotension (<90/50 mm Hg); unstable angina, heart failure, uncontrolled arrhythmias or hypertension.

Overdose

Single doses up to 500 mg have been given to healthy male subjects, and multiple daily doses up to 100 mg have been given to male patients with erectile dysfunction. Adverse reactions were similar to those seen at lower doses. Doses greater than 40 mg have not been studied in patients with pulmonary arterial hypertension. In cases of overdose, standard supportive measures should be adopted as needed. Hemodialysis contributes negligibly to Tadalafil elimination.

Warnings and Precautions

Hypotension
Tadalafil has vasodilatory properties that may result in transient decreases in blood pressure. Prior to prescribing tadalafil, carefully consider whether patients with underlying cardiovascular disease could be affected adversely by such vasodilatory effects.
Worsening Pulmonary Vascular Occlusive Disease
Pulmonary vasodilators may significantly worsen the cardiovascular status of patients with pulmonary veno-occlusive disease (PVOD). Since there are no clinical data on administration of tadalafil to patients with veno-occlusive disease, administration of tadalafil to such patients is not recommended.
Visual Loss
When used to treat erectile dysfunction, non–arteritic anterior ischemic optic neuropathy (NAION), a cause of decreased vision including permanent loss of vision, has been reported postmarketing in temporal association with the use of phosphodiesterase type 5 (PDE5) inhibitors, including tadalafil.
Hearing Impairment
Cases of sudden decrease or loss of hearing, which may be accompanied by tinnitus and dizziness, have been reported in patients taking tadalafil. It is not possible to determine whether these events are related directly to the use of PDE5 inhibitors or to other factors
Combination with Other PDE5 Inhibitors
Tadalafil is also marketed for erectile dysfunction. The safety and efficacy of taking tadalafil together with another PDE5 inhibitor has not been studied. Inform patients taking tadalafil not to take other PDE5 inhibitors.
Prolonged Erection
There have been reports of prolonged erections greater than 4 hours and priapism (painful erections greater than 6 hours in duration) for this class of compounds. Patients with conditions that might predispose them to priapism (such as sickle cell anemia, multiple myeloma, or leukemia), or in patients with anatomical deformation of the penis (such as angulation, cavernosal fibrosis, or Peyronie's disease) are at an increased risk.
Cardiovascular
Physicians should consider the cardiovascular status of their patients, since there is a degree of cardiac risk associated with sexual activity. Therefore, treatments for erectile dysfunction, including tadalafil, should not be used in men for whom sexual activity is inadvisable as a result of their underlying cardiovascular status.
Potential For Drug Interactions When Taking Tadalafil Tablets For Once Daily Use
Physicians should be aware that tadalafil tablets for once daily use provides continuous plasma tadalafil levels and should consider this when evaluating the potential for interactions with medications and with substantial consumption of alcohol.
Alcohol
Patients should be made aware that both alcohol and Tadalafil, a PDE5 inhibitor, act as mild vasodilators. When mild vasodilators are taken in combination, blood-pressure-lowering effects of each individual compound may be increased. Therefore, physicians should inform patients that substantial consumption of alcohol (e.g., 5 units or greater) in combination with tadalafil can increase the potential for orthostatic signs and symptoms, including increase in heart rate, decrease in standing blood pressure, dizziness, and headache.

Effects On Ability To Drive And Use Machines

Tadali (Tadalafil Tablets) has negligible influence on the ability to drive or use machines. Although the frequency of reports of dizziness in placebo and tadalafil arms in clinical trials was similar, patients should be aware of how they react to Tadali, before driving or using machines

Side Effects of Tadalafil Tablets

Most common Tadali tablets (Tadalafil) side effects with an incidence rate of 2% or more include headache, dyspepsia, back pain, myalgia, nasal congestion, flushing, and pain in limb. The following side effects have been reported during the course of Tadalafil tablets (Tadali):

• Cardiovascular System- Flushing, high blood pressure, angina pectoris, chest pain, hypotension, postural hypotension, MI, tachycardia, heart attack, palpitations, syncope, irregular heart rate, stroke and sudden cardiac death.
• Central Nervous System- Headache, asthenia, weakness, dizziness, fatigue, sensory loss, insomnia, mood changes, paresthesia, somnolence, tingling, drowsiness, vertigo, migraine, seizure and seizure recurrence, transient global amnesia, and temporary memory loss.
• Skin- Itching, rash, sweating, scaling, blistering or peeling of skin, Pruritus, swelling (especially of the face/tongue/throat), allergic reactions and hives.
• Eye and ENT- Nasopharyngitis, inflammation of nasopharynx, nasal congestion, blurred vision, changes in color vision, inflammation of conjunctiva, conjunctivitis including conjunctival hyperemia, epistaxis, nosebleed, eye pain, increased lacrimation, inflammation of pharynx, sudden decrease or loss of hearing, ringing in ears, retinal artery occlusion, swelling of eyelids, tinnitus, eye stroke and visual field defect.
• Gastrointestinal System- Upset stomach, gastroenteritis, gastroesophageal reflux, indigestion, nausea, stomach flu, acid reflux disease, abdominal pain, diarrhea, Dyspepsia, dry mouth, difficulty in swallowing, inflammation of esophagus, gastric ulcer, rectal hemorrhage, loose stools, dysphagia, esophagitis, gastritis, hemorrhoidal hemorrhage, increased GGT, and vomiting.
• Genitourinary System- Urinary tract infection, renal impairment, increased erection, spontaneous penile erection and painful erection or a prolonged erection that persists for more than 4 hours (that can be damaging for penis), and priapism.
• Liver- Abnormal Liver function tests.
• Musculoskeletal System- Muscle ache, myalgia, arthralgia, back pain, pain in extremities, limb pain, joint pain and neck pain.
• Respiratory System -Upper and lower respiratory tract infection, dyspnea, cough, inflammation of bronchus, and difficulty in breathing.
• Hypersensitivity- Exfoliative dermatitis, Stevens-Johnson syndrome, and urticaria.
• Miscellaneous- Influenza, face edema, and pain.

Inform your doctor immediately if you experience any of these side effects. This is not a comprehensive list of all the possible side effects of Megalic tablets (Generic Tadalafil). If you develop any other medical conditions during the course of treatment with Tadalafil tablets, please consult your doctor immediately.

Tadalafil Tablets During Pregnancy

Tadalafil (Tadali Tablets) has been classified by the US FDA as Pregnancy Category B.
Tadalafil tablets is not ordinarily used in women. During pregnancy, Tadalafil tablets should be used only when clearly necessary.
There are no data with the use of Tadalafil (Tadali) in pregnant women to inform any drug- associated risks for adverse developmental outcomes. In animal reproduction studies, no adverse developmental effects were observed with oral administration of Tadalafil to pregnant rats or mice during organogenesis at exposures up to 11 times the maximum recommended human dose (MRHD) of 20 mg/day.
Do not use this medicine without your doctor's consent in case you are pregnant. Stop using this medication and inform your doctor immediately if you become pregnant during treatment.

Nursing Considerations

Tadalafil (Tadali Tablets) is not indicated for use in females There is no information on the presence of Tadalafil and/or metabolites in human milk, the effects on the breastfed child, or the effects on milk production. Tadalafil and/or its metabolites are present in the milk of lactating rats at concentrations approximately 2.4-fold greater than found in the plasma.
Do not use this medication without telling your doctor if you are breast-feeding a baby.

Buy Generic Tadalafil 20 mg Pills Online From Only $0.50 per Pill

You can buy Generic Tadalafil Tablets online from Everest Online Pharmacy at a cheap price. Tadali 20 mg pills, manufactured by Alpha Pharma Healthcare Private limited, India, are supplied in a blister strip of 10 tablets. The 20 mg tablets cost only $0.50 per unit when you place an order for 1000 tablets.

Disclaimer

The above information is provided to the best of our knowledge and in good faith. It is without a warrant of any kind, expressed or implied.

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