Restasis Eye Drops

Restasis Eye Drops (Cyclosporine 0.05% Ophthalmic Emulsion) - Product Information

Restasis Eye Drops (Cyclosporine Ophthalmic Emulsion) are used to increase tear production in patients who have dry eyes due to eye inflammation (eg, keratoconjunctivitis sicca). This medicine may be used to treat vernal keratoconjunctivitis (allergic eye condition) and signs and symptoms of dry eye disease.
The active ingredient, Cyclosporine, is an immune inhibitor. It limits the production of enzymes that cause inflammation. Blocking eye inflammation that way helps increase tear fluid production, improving eye moisture.
Restasis Eye Drops manufactured by Allergan (USA) , are available in the strengths of 0.05% of Cyclosporine.
We also have in stock Careprost ophthalmic solution (Bimatoprost eye drops) which is used to treat certain diseases of the eye like open-angle glaucoma and ocular (eye) hypertension which occurs in many people as they grow older.

Name of the Drug

Restasis Eye Drops. This medicine is also known as Generic Cyclosporine Eye Drops.

Manufacturer of Restasis Eye Drops

Allergan (USA)  
Website: www.allergan.com

Active Pharmaceutical Ingredient

The active ingredient present in Restasis Eye Drops is Cyclosporine. Restasis Ophthalmic emulsion contains 0.5 mg/mL of Cyclosporine.

Uses of Restasis Ophthalmic Solution (Cyclosporine Eye Drops)

Restasis Ophthalmic Solution (Cyclosporine Eye Drops) 0.05% and 0.1% is a calcineurin inhibitor immunosuppressant used to increase tear production in patients whose tear production is presumed to be suppressed due to ocular inflammation associated with keratoconjunctivitis sicca. Increased tear production was not seen in patients currently taking topical anti-inflammatory drugs or using punctal plugs.

Restasis Eye Drops (Cyclosporine 0.05% Ophthalmic Emulsion) - Dosage

Restasis Eye Drops should be administered exactly as suggested by your doctor. Your doctor may recommend a dosage of Restasis Eye Drops depending on your age, medical requirement, body weight, other medical conditions, and current medications.
Instill one drop of Restasis ophthalmic emulsion twice a day in each eye approximately 12 hours apart. This recommended dose is the maximum recommended dose and should be used both as the starting dose and throughout long term treatment.

Continue using Cyclosporine Ophthalmic Solution without missing any doses for the recommended treatment period and do not stop the treatment suddenly even if you feel better. Please consult your doctor for exact dosing instructions. Restasis Eye Drops (Generic Cyclosporine 0.05% and 0.1% Ophthalmic Solution) should be administered in the dose prescribed by the doctor and for the duration recommended by the doctor.

Missed Dose

If you forget to administer your regular Restasis Eye Drops dose on time, use it whenever you remember.
However, if it is almost time for the next dose, the missed dose should be skipped, and the regular dosing schedule resumed. Doses should not be doubled. The dose should not exceed two drops in the affected eye(s) daily.

Mechanism of Action

Cyclosporine ophthalmic emulsion primarily functions as an immunomodulator to increase tear production in dry eye disease. It achieves this by inhibiting the activation of T-cells, which are immune cells involved in the inflammatory process associated with dry eye. By reducing T-cell activity, cyclosporine helps decrease inflammation in the eye, allowing the lacrimal glands to produce more tears
In patients whose tear production is presumed to be suppressed due to ocular inflammation associated with keratoconjunctivitis sicca, Cyclosporine emulsion is thought to act as a partial immunomodulator.

Storage Instructions for Restasis Eye Drops (Cyclosporine 0.05% Ophthalmic Solution)

Store Restasis Eye Drops at controlled room temperature (20°C to 25°C),protected from heat, moisture, and sunlight. Excursions are permitted from 15°C to 30°C.
Retain the original packing of the medication and do not use past its expiration date printed on the blister pack. Keep the pack of Cyclosporine Eye Drops away from the reach of children and pets. Do not dispose Restasis Eye Drops along with domestic waste or sewage. Consult your doctor or pharmacist about the correct method of disposal.

Contraindications

Restasis Eye Drops are contraindicated in patients with a hypersensitivity to Cyclosporine or any inactive ingredient present in Restasis Eye Drops.

Overdose

Due to low systemic concentrations of Cyclosporine after topical treatment with the ophthalmic emulsion, the likelihood of systemic intoxication from topical overdose is remote.

Warnings and Precautions

Potential For Eye Injury And Contamination:
To avoid the potential for eye injury and contamination, advise patients not to touch the vial tip to the eye or other surfaces
Use with Contact Lenses:
Cyclosporine ophthalmic emulsion should not be administered while wearing contact lenses. Patients with decreased tear production typically should not wear contact lenses. If contact lenses are worn, they should be removed prior to the administration of the emulsion. Lenses may be reinserted 15 minutes following administration of cyclosporine ophthalmic emulsion.
Immune
There is the potential to experience hypersensitivity to Restasis Eye Drops. Reactions of severe angioedema, face swelling, tongue swelling, pharyngeal edema, dyspnea and urticaria have been reported with the use of Cyclosporine 0.05% and 0.1% Eye Drops.
Driving and Operating Machinery
Restasis Eye Drops may cause transient blurred vision due to its emulsion formulation. If patients experience blurred vision, they should be advised not to drive or operate machinery until vision has cleared.
Ophthalmologic
Restasis Eye Drops has not been studied in patients with a history of herpes keratitis, end stage lacrimal gland disease, keratoconjunctivitis sicca (KCS) secondary to the destruction of conjunctival goblet cells such as occurs with Vitamin A deficiency, or scarring, such as occurs with cicatricial pemphigoid, alkali burns, Stevens Johnson syndrome, trachoma, or irradiation .

Side Effects of Cyclosporine 0.05% Ophthalmic Solution (Restasis Eye Drops)

During clinical trials the most common side effect following the use of Cyclosporine 0.05% and 0.1% Ophthalmic Solution was ocular burning (17%). Other reactions reported in 1% to 5% of patients included conjunctival hyperemia, discharge, epiphora, eye pain, foreign body sensation, pruritus, stinging, and visual disturbance (most often blurring).
The following adverse reactions have been identified during post approval use of Restasis Eye Drops (Cyclosporine 0.05% and 0.1% Ophthalmic Solution). Because these reactions are reported voluntarily from a population of uncertain size, it is not always possible to reliably estimate their frequency or establish a causal relationship to drug exposure.
Reported reactions have included: hypersensitivity (including eye swelling, urticaria, rare cases of severe angioedema, face swelling, tongue swelling, pharyngeal edema and dyspnea); and superficial injury of the eye (from the vial tip touching the eye during administration).

Cyclosporine Ophthalmic Emulsion ( Restasis 0.05% Eye Drops) During Pregnancy

Cyclosporine Ophthalmic Emulsion has been classified by the US FDA as Pregnancy Category C.
No evidence of embryofetal toxicity was observed in rats or rabbits receiving cyclosporine at oral doses up to 17 mg/kg/day or 30 mg/kg/day, respectively, during organogenesis. These doses in rats and rabbits are approximately 3,000 and 10,000 times greater (normalized to body surface area), respectively, than the daily human dose. There are no adequate and well-controlled studies of Cyclosporine Eye Drops in pregnant women. Restasis Eye Drops should be administered to a pregnant woman only if clearly needed.
Do not use this medicine without your doctor's consent in case you are pregnant. Stop using this medication and inform your doctor immediately if you become pregnant during treatment.

Cyclosporine Eye Drops - Nursing Considerations

Cyclosporine is known to be excreted in human milk following systemic administration but excretion in human milk after topical treatment has not been investigated. Although blood concentrations are undetectable after topical administration of Restasis Eye Drops, caution should be exercised when Restasis Eye Drops is administered to a nursing woman
Do not use this medication without telling your doctor if you are breast-feeding a baby.

You can buy Restasis Eye Drops online from Clear Sky Pharmacy at a cheap price.

Buy Cyclosporine 0.05% Ophthalmic Emulsion (Restasis Eye Drops) Online From Only $3.83 per Vial

You can buy Cyclosporine 0.05% Ophthalmic Emulsion online from Everest Online Pharmacy at a cheap price. Restasis 0.05% Eye Drops, manufactured by Allergan, USA are supplied in a box containing 30 vials. Restasis Eye Drops box of 30 vials in 0.05% strength costs only $3.83 per vial if you place an order for 120 Vials (4 Boxes).

Disclaimer

The above information is provided to the best of our knowledge and in good faith. It is without a warrant of any kind, expressed or implied.

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