Rabeprazole Sodium Tablets

Rabicip (Generic Rabeprazole Sodium Tablets) - Product Information

Rabicip (Generic Rabeprazole Sodium Tablets) is used for the treatment of gastro-oesophageal reflux disease (GERD), duodenal ulcers and Zollinger-Ellison syndrome.
Rabeprazole is used to treat duodenal ulcers, gastroesophageal reflux disease (GERD), and Zollinger-Ellison syndrome, a condition where the stomach produces too much acid. It may also be used together with antibiotics (eg, amoxicillin, clarithromycin) to treat ulcers associated with infections caused by the H. pylori bacteria. Rabeprazole is a proton pump inhibitor (PPI) that decreases the amount of acid produced by the stomach.
Rabicip tablets, manufactured by is available in the strength of 20 mg.
We also have in stock Lansoprazole Capsules (Lan 15 mg & 30 mg Capsules) which are gastro-intestinal medications used to decrease the amount of acid formed in the stomach during digestion.

Name of the Drug

Rabicip Tablets.

Manufacturer of Rabicip Tablets

Cipla Limited, India  
Website: www.cipla.com

Active Pharmaceutical Ingredient

The active ingredient present in Rabicip tablets.
Each enteric-coated Rabicip tablet contains 20 mg of Rabeprazole Sodium.

Uses of Generic Rabeprazole Sodium Tablets (Rabicip)

Gastro-oesophageal reflux disease (GERD)
This can be caused by food and acid from the stomach flowing the wrong way (reflux) back up the food pipe, also known as the oesophagus.
Reflux can cause a burning sensation in the chest rising up to the throat, also known as heartburn.
Rabeprazole sodium is also used to help stop reflux oesophagitis from coming back or relapsing.
Gastric And Duodenal Ulcers:
Depending on the position of the ulcer it is called a gastric or duodenal ulcer. A gastric ulcer occurs in the stomach. A duodenal ulcer occurs in the duodenum which is the tube leading out of the stomach. These ulcers can be caused by too much acid being made in the stomach.
Most people who have a peptic ulcer also have a bacteria called Helicobacter pylori in their stomach. Your doctor may also prescribe a course of antibiotics (clarithromycin and amoxycillin) for you. When this medicine is taken with antibiotics, the combination therapy will kill the Helicobacter pylori and let your ulcer heal.

Chronic Gastritis
The presence of the bacteria Helicobacter pylori may cause the stomach to become inflamed, resulting in pain, nausea and vomiting; all of which are signs of chronic gastritis.

Rabicip (Rabeprazole Sodium Tablets) - Dosage

Generic Rabeprazole Sodium tablets should be administered exactly as suggested by your doctor. Your doctor may recommend a dosage of Rabicip tablets depending on your age, medical requirement, body weight, other medical conditions, and current medications.
Symptomatic Relief and Healing of Erosive or Ulcerative Gastroesophageal Reflux Disease (GERD)
The recommended adult oral dose is 20 mg once daily (QD). In most patients, healing occurs in four weeks. For patients not healed after this initial course, an additional four weeks of treatment is recommended. Symptom relief is usually rapid. If symptom relief is not achieved after four weeks, further investigation is recommended.
Long-term Maintenance of Healing of Erosive or Ulcerative Gastroesophageal Reflux Disease (GERD Maintenance)
10 mg QD has been demonstrated to be effective versus placebo in the maintenance of healing of GERD. The maximum recommended adult oral dose is 20 mg once daily. Treatment of Symptoms (i.e., Heartburn and Regurgitation) of Symptomatic Gastroesophageal Reflux Disease (GERD) or Non-erosive Reflux Disease (NERD) The recommended adult oral dose is 10 mg QD to a maximum of 20 mg QD in patients with NERD. If symptom control is not achieved after four weeks, further investigation is recommended.
Symptomatic Relief and Healing of Duodenal Ulcers
The recommended adult oral dose is 20 mg once daily for up to four weeks. Most patients with duodenal ulcer heal within four weeks, but a few patients may require additional therapy to achieve healing. Symptom relief is usually rapid with improvement achieved after two weeks for most patients.
Symptomatic Relief and Healing of Gastric Ulcers
The recommended adult oral dose is 20 mg once daily for up to six weeks. Most patients with gastric ulcer heal within six weeks, but a few patients may require additional therapy to achieve healing. Symptom relief is usually rapid with improvement achieved after three weeks for most patients.
Long-term Treatment of Pathological Hypersecretory Conditions Including Zollinger-Ellison Syndrome
The Sandoz Rabeprazole dosage in patients with pathologic hypersecretory conditions varies with the individual patient. The recommended adult oral starting dose is 60 mg once daily (QD). Doses should be adjusted to individual patient needs and should continue for as long as clinically indicated. Some patients may require divided doses. Doses up to 100 mg once daily (QD) and 60 mg two times a day (BID) have been administered. Some patients with Zollinger-Ellison syndrome have been treated continuously with rabeprazole sodium tablets for up to one year.
Rabicip tablets work effectively if the amount of Rabeprazole Sodium is maintained at a constant level in the body. You should be systematic about the daily schedule for the medication such that you take tablets at about the same time every day, to get the maximum benefit of the medication. Continue taking Rabicip tablets without missing any doses for the recommended treatment period and do not stop the treatment suddenly even if you feel better.

Please consult your doctor for exact dosing instructions. Rabicip tablets (Generic Rabeprazole Sodium tablets) should be administered in the dose prescribed by the doctor and for the duration recommended by the doctor.

Missed Dose

If you forget to take your regular Rabicip tablet dose on time, take it whenever you remember.
If you remember the next day, skip the missed dose and take your scheduled dose. Do not take a double dose to compensate the missed dose.

Rabeprazole Sodium Mechanism of Action

Rabeprazole belongs to a class of antisecretory compounds (substituted benzimidazole proton-pump inhibitors) that do not exhibit anticholinergic or histamine H2-receptor antagonist properties, but suppress gastric acid secretion by inhibiting the gastric H+, K+ATPase at the secretory surface of the gastric parietal cell.
Because this enzyme is regarded as the acid (proton) pump within the parietal cell, rabeprazole has been characterized as a gastric proton-pump inhibitor. Rabeprazole blocks the final step of gastric acid secretion.

Storage Instructions for Rabicip Tablets

Store Rabicip (Rabeprazole Sodium Tablets) at controlled room temperature (20°C to 25°C),protected from heat, moisture, and sunlight. Excursions are permitted from 15°C to 30°C.
Retain the original packing of the medication and do not consume past its expiration date printed on the blister pack. Keep the pack of Rabeprazole Sodium tablets away from the reach of children and pets. Do not dispose Rabicip tablets along with domestic waste or sewage. Consult your doctor or pharmacist about the correct method of disposal.

Contraindications

Rabicip tablets are contraindicated in patients with a hypersensitivity to Rabeprazole Sodium or any inactive ingredient present in tablets.
Amoxicillin is contraindicated in patients with a known hypersensitivity to any penicillin. Clarithromycin is contraindicated in patients with known hypersensitivity to clarithromycin, erythromycin or other macrolide antibacterial agents. Clarithromycin is also contraindicated in patients receiving concurrent therapy with astemizole, terfenadine, cisapride or pimozide.

Overdose

Seven reports of accidental overdosage with Rabeprazole Sodium (Rabicip tablets) have been received. The maximum reported overdose was 80 mg. There were no clinical signs or symptoms associated with any reported overdose. Patients with Zollinger-Ellison syndrome have been treated with up to 120 mg rabeprazole once daily. No specific antidote for rabeprazole is known. Rabeprazole is extensively protein bound and is not readily dialyzable.
In the event of overdosage, treatment should be symptomatic and supportive.

Warnings and Precautions

Symptomatic response to therapy with Rabeprazole does not preclude the presence of gastric malignancy
Use with warfarin:Monitor for increases in INR and prothombin time.
Acute interstitial nephritis has been observed in patients taking PPIs.
Cyanocobalamin (vitamin B-12) Deficiency: Daily long-term use (e.g., longer than 3 years) may lead to malabsorption or a deficiency of cyanocobalamin.
PPI therapy may be associated with increased risk of Clostridium difficile associated diarrhea.
Bone fracture:Long-term and multiple daily dose PPI therapy may be associated with an increased risk for osteoporosis-related fractures of the hip, wrist, or spine.
Hypomagnesemia has been reported rarely withprolonged treatment with PPIs

Effects on Ability to Drive and Use Machines

Based on the pharmacodynamic properties and the adverse events profile, it is unlikely that rabeprazole sodium 20 mg tablets would cause an impairment in driving performance or compromise the ability to use machinery.
If however, alertness is impaired due to somnolence, it is recommended that driving and operating complex machinery be avoided.

Side Effects of Rabeprazole Sodium Tablets (Rabicip)

In the adult studies (4 to 8 weeks), Rabeprazole Sodium side effects that occurred at a rate greater than 2% and greater than placebo included pain, pharyngitis, flatulence, infection, and constipation.
In studies of pediatric and adolescent patients (ages 1 to 16years, and up to 36 weeks exposure) adverse reactions that occurred at a rate of 5% or more of patients included abdominal pain, diarrhea, and headache.

Rabeprazole Sodium During Pregnancy

Rabeprazole Sodium Tablets (Rabicip) has been classified by the US FDA as Pregnancy Category B.
There is no data on the safety of Rabeprazole Sodium in human pregnancy. Reproduction studies performed in rats and rabbits have revealed no evidence of impaired fertility or harm to the foetus due to rabeprazole sodium, although low foeto-placental transfer occurs in rats. Rabeprazole sodium 20 mg tablets are contraindicated during pregnancy.
Do not use this medicine without your doctor's consent in case you are pregnant. Stop using this medication and inform your doctor immediately if you become pregnant during treatment.

Nursing Considerations

It is not known whether Rabeprazole Sodium (Rabicip) is excreted in human breast milk. No studies in lactating women have been performed. Rabeprazole Sodium is however excreted in rat mammary secretions. Therefore, Rabeprazole Sodium 20 mg tablets must not be used during breastfeeding.
Do not use this medication without telling your doctor if you are breast-feeding a baby.

Buy Rabeprazole Sodium 20 mg Pills Online From Only $0.60 per Pill

You can buy Rabeprazole Sodium tablets online from Everest Online Pharmacy at a cheap price. Rabicip 20 mg pills, manufactured by Cipla Limited, India, are supplied in a blister strip of 15 tablets. The 20 mg tablets cost only $0.60 per unit when you place an order for 180 tablets.

Disclaimer

The above information is provided to the best of our knowledge and in good faith. It is without a warrant of any kind, expressed or implied.

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