Pramirol Tablets

Generic Pramipexole Dihydrochloride (Pramirol Tablets) - Product Information

Generic Pramipexole Dihydrochloride tablets (Pramirol tablets) are indicated for the treatment of the signs and symptoms of idiopathic Parkinson's disease.
Pramirol is also used to treat Restless Legs Syndrome (RLS).
In our online pharmacy, Pramirol tablets are available in the strength of 0.125 mg, 0.25 mg ,0.5 mg, 0.75 mg , 1 mg and 1.5 mg of Pramipexole Dihydrochloride.
We also have in stock Donepezil Hydrochloride Tablets (Donecept) which is also used for the treatment of dementia, which is characteristic of patients suffering from mild to moderate Alzheimer's disease.

Name of the Drug

Pramirol Tablets. Pramirol tablets are also known as Parpex, Pramipex and Generic Pramipexole Dihydrochloride tablets.

Manufacturer of Pramirol Tablets

Intas Pharmaceuticals Limited, India. 
Website: www.intaspharma.com

Active Pharmaceutical Ingredient

The active ingredient present in Pramirol tablets is Pramipexole Dihydrochloride. Each Pramirol tablet contains 0.125 mg, 0.25 mg ,0.5 mg or 1 mg of Pramipexole Dihydrochloride.
The inactive ingredients present in Generic Pramipexole Dihydrochloride pills are colloidal silicon dioxide, copovidone, cornstarch, magnesium stearate, and microcrystalline cellulose.

Pramirol Indications – What is Pramipexole Dihydrochloride Used For?

Pramirol tablets, manufactured by , in strengths of 0.5 mg, are commonly used as oral therapy for the treatment of Parkinson's disease. Pramipexole Dihydrochloride tablets belongs to the class of drugs called dopamine agonists.
Pramirol tablets are known to mimic the effects of the naturally-occurring Dopamine neurotransmitter in the brain. Parkinson's patients are known to have low levels of dopamine activity in the brain.
Pramipexole Dihydrochloride tablets are used for the effective treatment of the characteristic symptoms of Parkinson's disease such as stiffness, tremors, muscle spasms, and poor muscle control. Pramirol tablets is also used to treat moderate to severe restless legs syndrome (RLS).

Pramipexole Dihydrochloride Dosage - How to Take Pramirol Tablets?

Generic Pramipexole Dihydrochloride tablets should be administered exactly as suggested by your doctor. Your doctor may recommend a dosage of Pramirolole tablets depending on your age, medical requirement, body weight, other medical conditions, and current medications. Pramirol tablets should be swallowed with a glass of water. Pramipexole Dihydrochloride tablets should be administered either before or preferably after a meal to avoid gastrointestinal problems.
You doctor may alter the dosage and the number of times you should take Pramipexole Dihydrochloride tablets depending on your response to treatment and the severity of your medical condition.
You should be systematic about the daily schedule for the medication such that you take Pramirol tablets at the same time every day, to get the maximum benefit of the medication. Continue taking Pramirol tablets for the recommended treatment period and do not stop the treatment suddenly even if you feel that your symptoms have cleared. The dosage of Pramipexole Dihydrochloride tablets should be gradually decreased otherwise it will result in unpleasant withdrawal symptoms.
The recommended dosage for the treatment of Parkinson's disease is 0.375 mg per day which may divided into three doses during the day. The initial dosage in Parkinson's patients may be gradually increased after a gap of 5 to 7 days. The maximum recommended daily dosage is 4.5 mg, which can be administered as multiple doses every 8 hours.
For patients taking Pramipexole Dihydrochloride tablets for the treatment of restless legs syndrome (RLS), the recommended daily starting dose is 0.125 mg. The dosage of Pramipexole Dihydrochloride tablets in these patients should be administered 2 to 3 hours before bedtime. The initial dosage in Parkinson's patients may be gradually increased after a gap of 4 to 7 days.
The maximum recommended daily dosage is 0.5 mg, which can be administered 2 to 3 hours before bedtime. The treatment period with Pramirolole tablets should be maintained at 12 weeks. In case of an overdose with Pramirol tablets, please seek emergency help immediately.
Please consult your doctor for exact dosing instructions. Pramirol tablets (Generic Pramipexole Dihydrochloride tablets) should be administered in the dose prescribed by the doctor and for the duration recommended by the doctor.

Pramipexole Dihydrochloride Mechanism of Action – How Does Pramirol Work?

Pramipexole Dihydrochloride is a medication used for the treatment of Parkinson's disease and restless legs syndrome (LS). Pramirol tablets belongs to the class of drugs known as dopamine agonists.
Parkinson’s Disease: The precise mechanism of action of Pramipexole as a treatment for Parkinson's disease is unknown, although it is believed to be related to its ability to stimulate dopamine receptors in the striatum. This conclusion is supported by electrophysiologic studies in animals that have demonstrated that pramipexole influences striatal neuronal firing rates via activation of dopamine receptors in the striatum and the substantia nigra, the site of neurons that send projections to the striatum. The relevance of D3 receptor binding in Parkinson’s disease is unknown.
Restless Legs Syndrome (RLS): The precise mechanism of action of Pramirol (Pramipexole Dihydrochloride) tablets as a treatment for Restless Legs Syndrome (RLS) is unknown. Although the pathophysiology of RLS is largely unknown, neuropharmacological evidence suggests primary dopaminergic system involvement. Positron Emission Tomographic (PET) studies suggest that a mild striatal presynaptic dopaminergic dysfunction may be involved in the pathogenesis of RLS.

Storage Instructions for Pramirol Tablets

Store Pramirol tablets at controlled room temperature (20°C to 25°C), protected from heat, moisture, and sunlight. Excursions are permitted from 15°C to 30°C.
Retain the original packing of the medication and do not consume Pramipexole Dihydrochloride tablets (Pramirol) beyond its expiration date printed on the blister pack. Keep the pack of Generic Pramipexole Dihydrochloride tablets away from the reach of children and pets.
Do not discard Pramirol tablets along with domestic waste or sewage. Consult your doctor or pharmacist about the correct method of disposal.

Contraindications

Pramirol tablets are contraindicated in patients with a known hypersensitivity to Pramipexole Dihydrochloride or any inactive ingredient present in Pramirol tablets.

Missed Dose

If you miss your regular dose of Pramirol tablets, take it as soon as you remember. You can continue your regular schedule the next day.
If you remember the missed Pramipexole Dihydrochloride tablets the next day, take your regular dose and skip the missed dose. Do not take a double dose to compensate the missed dose of Pramirol tablets.

Overdose

There is no clinical experience with massive overdosage. One patient, with a 10-year history of Schizophrenia, took 11 mg/day of Pramipexole Dihydrochloride for 2 days in a clinical trial to evaluate the effect of Pramipexole Dihydrochloride in schizophrenic patients. No adverse events were reported related to the increased dose.
Blood pressure remained stable although pulse rate increased to between 100 and 120 beats/minute. The patient withdrew from the study at the end of week 2 due to lack of efficacy.

Warnings and Precautions

Medical History
Before beginning the treatment with Pramirol tablets (Generic Pramipexole Dihydrochloride tablets), discuss your personal and family medical history with your doctor. Inform your doctor if you have narcolepsy (a sleep disorder), kidney disease, low blood pressure, dizziness or fainting when you sit or stand up, tremors (dyskinesia) or uncontrolled muscle movements.
Allergy
Please inform your doctor if you have an allergy or have had an allergic reaction in the past to Pramipexole Dihydrochloride or any inactive ingredient in Pramirol tablets. Please tell your doctor if you have any other allergies.
Pramipexole Dihydrochloride Tablets and Alcohol
Avoid or limit the consumption of alcohol during the treatment with Generic Pramipexole Dihydrochloride tablets (Pramirol tablets) and consult your doctor for further information.
Falling asleep during activities of daily living:
Sudden onset of sleep may occur without warning; advise patients to report symptoms. Patients receiving treatment with pramipexole dihydrochloride and other dopaminergic agents have reported suddenly falling asleep while engaged in activities of daily living, including operating a motor vehicle, which sometimes resulted in accidents.
Symptomatic orthostatic hypotension:
Monitor during dose escalation
Impulse control/Compulsive behaviors:
Patients may experience compulsive behaviors and other intense urges
Hallucinations and Psychotic-like Behavior:
May occur; risk increases with age
Dyskinesia:
May be caused or exacerbated by Pramirol
Postural Deformity:
Consider reducing the dose or discontinuing Pramirol if postural deformity occurs

Side Effects of Pramipexole Dihydrochloride

Most common Pramipexole Dihydrochloride side effects (incidence rate greater than 5% and greater than placebo):

• Early PD without levodopa: nausea, dizziness, somnolence, insomnia, constipation, asthenia, and hallucinations
• Advanced PD with levodopa: postural (orthostatic) hypotension, dyskinesia, extrapyramidal syndrome, insomnia, dizziness, hallucinations, accidental injury, dream abnormalities, confusion, constipation, asthenia, somnolence, dystonia, gait abnormality, hypertonia, dry mouth, amnesia, and urinary frequency
• RLS: nausea, somnolence, fatigue, and headache

Inform your doctor immediately if you experience any of these side effects. This is not an exhaustive list of all the potential side effects of Pramirol tablets (Generic Pramipexole Dihydrochloride tablets). Please contact your doctor immediately in case you develop any other medical conditions during the course of treatment with Pramipexole Dihydrochloride tablets.

Pramipexole Dihydrochloride Tablets during Pregnancy and Breastfeeding

Pramipexole Dihydrochloride has been classified by the US FDA as Pregnancy Category C.
There are no adequate data on the developmental risk associated with the use of Pramipexole Dihydrochloride in pregnant women. No adverse developmental effects were observed in animal studies in which Pramirolole was administered to rabbits during pregnancy. The administration of Pramirolole Tablets in pregnant women is not known to cause any harm in the unborn fetus.
Pramirolole is not known to be transmitted to a baby through breastmilk. However, nursing mothers should avoid breastfeeding an infant during the course of Pramipexole Dihydrochloride tablets.
Pregnant women and nursing mothers who are undergoing treatment with Pramirolole tablets should consult their doctor and understand its therapeutic benefits and accompanying risks before continuing the course of treatment with Pramipexole Dihydrochloride tablets.
Do not use this medicine without your doctor's consent in case you are pregnant. Stop using this medication and inform your doctor immediately if you become pregnant during treatment.

Buy Generic Pramipexole Dihydrochloride 0.125 mg, 0.25 mg ,0.5 mg, and 1  mg Pills Online From Only $0.33 per Pill

You can buy Generic Pramipexole Dihydrochloride online from Everest Online Pharmacy at a cheap price. Pramirol 0.125 mg, 0.25 mg ,0.5 mg, 0.75 mg , 1 mg and 1.5 mg pills, manufactured by Intas Pharmaceuticals Limited, India, are supplied in a blister strip of 10 tablets. The 0.125 mg tablets cost only $0.33 per unit when you place an order for 500 tablets.

Disclaimer

The above information is provided to the best of our knowledge and in good faith. It is without a warrant of any kind, expressed or implied.

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