Megalis Tablets

Tadalafil Tablets (Megalis) - Product Information

Tadalafil tablets are orally administered drugs which act as muscle relaxants and also increase penile blood flow. Tadalafil Tablets are primarily used for the treatment of erectile dysfunction in men. Tadalafil tablets are also used to cure the symptoms of benign prostatic hypertrophy (enlarged prostate).
Megalis tablets also enhance the physical stamina in pulmonary arterial hypertension (PAH) patients. Tadalafil tablets treat PAH by its relaxing action on the blood vessels in the lungs, resulting in improved blood flow and better energy levels.
Tadalafil tablets of strengths, 10 mg and 20 mg are available in our online pharmacy.
We also have in stock Sildenafil Oral Jelly (Kamagra Jelly) which is also used as an fast acting oral therapy for erectile dysfunction (male impotence) and works efficaciously to relax the muscles in the penile area.

Name of the Drug

Megalis Tablets.
Tadalafil tablets are also available under other generic brand names such as Tadacip, Tadalis, and Forzest.

Manufacturer of Megalis Tablets

Megalis tablets which are available at our online pharmacy are manufactured by Macleods Pharmaceuticals  
Website: www.macleodspharma.com

Active Pharmaceutical Ingredient

The active ingredient present in Megalis tablets is Tadalafil. Each Megalis tablet contains either 10 mg or 20 mg of Tadalafil.
The inactive ingredients in Tadalafil tablets are croscarmellose sodium, hydroxypropyl cellulose, hypromellose, iron oxide, lactose monohydrate, magnesium stearate, microcrystalline cellulose, sodium lauryl sulfate, talc, titanium dioxide, and triacet.

What are Megalis Tablets Used For?

Tadalafil Tablets for Erectile Dysfunction
Tadalafil tablets are used for the treatment of impotence in men. This condition is medically identified as erectile dysfunction. Tadalafil tablets enhance the flow of blood to the penis during sexual stimulation. This increase in blood flow helps in achieving a lasting erection during sexual stimulation. The effects of Tadalafil tablets can last up to 36 hours.
Tadalafil Tablets for Benign Prostatic Hyperplasia (BPH)
Tadalafil tablets are also used for the treatment of medical conditions that arise due to the development of an enlarged prostate (also known as benign prostatic hyperplasia-BPH) such as difficulty in beginning urine flow, weak urine stream, frequent or urgent urination (such as during the middle of the night). Tadalafil tablets are known to treat these symptoms by relaxing effect on the smooth muscles of the prostate and bladder.
Tadalafil Tablets for Pulmonary Arterial Hypertension (PAH)
Tadalafil tablets also enhance the physical stamina in pulmonary arterial hypertension (PAH) patients. Tadalafil treats PAH by its relaxing action on the blood vessels in the lungs, resulting in improved blood flow and better energy levels.
Tadalafil tablets are not contraceptives and does not protect against sexually transmitted diseases (HIV, hepatitis B, gonorrhea, syphilis). Use proper contraceptive methods (latex condoms) for "safe sex".

Dosage

Megalis tablets (Generic Tadalafil) are intended for oral administration. Tadalafil tablets should be used as recommended by your doctor.
Megalis tablets can be administered before or after food. If you are using Tadalafil tablets on a need-basis, you can take the tablet at least 30 minutes before the sexual activity, or as directed by your doctor. The effects of Tadalafil tablets usually remains for up to 36 hours after administration.
Benign Prostatic Hyperplasia patients, who are recommended a daily dose of Megalis tablets, should stick to a regular schedule, such that they take the medication at the same time every day.
The doctor will suggest a dosage and dosage period based on your medical condition, response to treatment, and other drugs you may be taking.
Please consult your doctor for exact dosing instructions. Megalis tablets (Generic Tadalafil tablets) should be administered in the dose prescribed by the doctor and for the duration recommended by the doctor.

Missed Dose

Tadalafil tablets are consumed on a need-basis before engaging in sexual activity. However, doctors recommend a regular daily dose of Tadalafil tablets for certain medical conditions.
If you forget to take dose of Megalis tablets during the course of a regular schedule, take it as soon as you remember. If the time for the next dose is near, skip the missed dose and continue your standard dosing schedule. Do not administer a double dose in a single day to compensate the missed dose.

Megalis Mechanism of Action – How Does Tadalafil Work?

Erection during sexual stimulation can be easily attained when there is increased blood circulation in the penis. Increased blood circulation takes place due to the increase in the size of blood vessels that supply the blood to the penis. Simultaneously, the blood vessels that take out blood from the penis shrink in size, which result in lesser removal of blood from the penis.
When an erection occurs during sexual stimulation, it results in the production and release of nitric oxide in the penis. The nitric oxide activates an enzyme called guanylate cyclase to produce cyclic guanosine monophosphate (cGMP). cGMP mainly controls the increase and decrease of the size of blood vessels which supply and take away blood from the penis, resulting in a lasting erection.
An enzyme called phosphodiesterase-5 suppresses the activity of cGMP. When there is a deficiency of cGMP in the penis, the blood vessels return to their normal size, resulting in a decreased supply of blood to the penis. This situation leads to a termination of penis erection.
Tadalafil tablets belong to a group of drugs called phosphodiesterase-5 (PDE5) inhibitors. Other drugs in this group include Sildenafil (Viagra) and Vardenafil (Levitra). Tadalafil tablets inhibit the activity of the phosphodiesterase-5 enzyme. During Tadalafil treatment, phosphodiesterase-5 enzyme are no longer available to suppress cGMP. The presence of cGMP leads to an increased blood flow, resulting in an extended enlargement of the penis.
The mechanism of action of Tadalafil tablets to cure the symptoms of BPH is not still unknown. Phosphodiesterase-5 enzyme is present in the muscles of the bladder and the prostate. It has been suggested that the passage of urine can be made easier by bringing about the relaxation of these muscles. For example, the reduction of pressure in the muscle surrounding the opening to the urethra (the body part that controls the flow of urine from the bladder) may result in an easier flow of urine.

Storage Instructions for Megalis Tablets

Store Tadalafil tablets (Megalis) at controlled room temperature (20°C to 25°C). Excursions are permitted from 15°C to 30°C.
Keep the pack of Tadalafil tablets protected from heat, moisture, and sunlight. Retain the original packing of the medication and do not consume Tadalafil tablets past its expiration date printed on the blister pack. Keep the pack of Tadalafil tablets away from the reach of children and pets.
Do not dispose Tadalafil tablets along with domestic waste or sewage. Consult your doctor or pharmacist about the correct method of disposal.

Contraindications

The use of Megalis tablets are contraindicated in patients with chest pain or heart problems who are currently using organic nitrates, nitrates and nitric oxide donors such as nitroglycerin (Nitrostat, Nitrolingual, Nitro-Dur, Nitro-Bid, Minitran, Deponit, Transderm-Nitro), isosorbide dinitrate (Dilatrate-SR, Isordil, Sorbitrate), isosorbide mononitrate (Imdur, ISMO, Monoket), or recreational drugs such as amyl nitrate or nitrite ("poppers"). The concomitant administration of Megalis tablets with a nitrate drug can result in a severe decrease in blood pressure, leading to fainting, stroke, or heart attack.
Megalis tablets are also contraindicated in men with cardiac disease for whom sexual activity is inadvisable; recent MI (within 90 days) or stroke (within last 6 months), hypotension (<90/50 mm Hg); unstable angina, heart failure, uncontrolled arrhythmias or hypertension; known hypersensitivity to Tadalafil or other inactive ingredients present in Megalis tablets.

Overdose

Single doses up to 500 mg have been given to healthy subjects, and multiple daily doses up to 100 mg have been given to patients. Adverse events were similar to those seen at lower doses.
In cases of overdose, standard supportive measures should be adopted as required. Hemodialysis contributes negligibly to tadalafil elimination.

Warnings and Precautions to be taken when using Tadalafil Tablets

Medical History
Before beginning the course of Tadalafil tablets, let your doctor know about your personal and family medical history. Inform your doctor if have or have had heart disease or heart rhythm problems; a heart attack (within the past 90 days); stroke or congestive heart failure (within the past 6 months); angina (chest pain); high or low blood pressure; liver disease; kidney disease (or if you are on dialysis); diabetes or thyroid problems; severe bladder infection; a blood cell disorder (sickle cell anemia, multiple myeloma, or leukemia); dehydration; a bleeding disorder (hemophilia); stomach ulcer; retinitis pigmentosa (an inherited condition of the eye), sudden decreased vision, NAION; painful/prolonged erection (priapism); a physical deformity of the penis (angulation, fibrosis/scarring, Peyronie's disease); or if you have been advised to abstain from sexual intercourse for health reasons (heart problems).
Tadalafil Interactions
Before starting the course of Megalis tablets (Generic Tadalafil), inform your doctor about all your current medications such as prescription drugs, over the counter medications, herbal products, mineral supplements, and vitamins. Avoid beginning, discontinuing, or altering the dosage of any medication without informing your doctor. Tadalafil tablets are known to interact with other drugs. Such drug interactions may change the effectiveness of Tadalafil tablets or may increase the possibility of serious side effects. Some of the drugs that have known interactions with Tadalafil tablets are riociguat; nitrate drugs (nitroglycerin, isosorbide), recreational drugs called "poppers" containing amyl or butyl nitrite; alpha blocker medication (doxazosin, tamsulosin); azole antifungals (itraconazole, ketoconazole); macrolide antibiotics (clarithromycin, erythromycin); HIV protease inhibitors (fosamprenavir, ritonavir); hepatitis C virus protease inhibitors (boceprevir, telaprevir); rifampin; other medications used to treat erectile dysfunction or pulmonary hypertension (sildenafil, vardenafil).
Allergic Reactions
Before starting the course of Tadalafil tablets, inform your doctor if you are allergic to or if you had any allergic reactions in the past to Tadalafil or any other inactive ingredients present in Megalis tablets.
Tadalafil and Alcohol
The simultaneous administration of alcohol along with Tadalafil tablets increases the probability of orthostatic symptoms such as increased heart rate, decreased in blood pressure, dizziness, and headache.
Driving and Other Activities
The administration of Tadalafil tablets may make you feel dizzy. Avoid activities which require you to be alert such as driving and using machinery, until you are sure you can them carry out without harm.

Side Effects of Tadalafil Tablets

The following side effects have been reported during the course of Tadalafil tablets (Megalis):

• Cardiovascular System- Flushing, high blood pressure, angina pectoris, chest pain, hypotension, postural hypotension, MI, tachycardia, heart attack, palpitations, syncope, irregular heart rate, stroke and sudden cardiac death.
• Central Nervous System- Headache, asthenia, weakness, dizziness, fatigue, sensory loss, insomnia, mood changes, paresthesia, somnolence, tingling, drowsiness, vertigo, migraine, seizure and seizure recurrence, transient global amnesia, and temporary memory loss.
• Skin- Itching, rash, sweating, scaling, blistering or peeling of skin, Pruritus, swelling (especially of the face/tongue/throat), allergic reactions and hives.
• Eye and ENT- Nasopharyngitis, inflammation of nasopharynx, nasal congestion, blurred vision, changes in color vision, inflammation of conjunctiva, conjunctivitis including conjunctival hyperemia, epistaxis, nosebleed, eye pain, increased lacrimation, inflammation of pharynx, sudden decrease or loss of hearing, ringing in ears, retinal artery occlusion, swelling of eyelids, tinnitus, eye stroke and visual field defect.
• Gastrointestinal System- Upset stomach, gastroenteritis, gastroesophageal reflux, indigestion, nausea, stomach flu, acid reflux disease, abdominal pain, diarrhea, Dyspepsia, dry mouth, difficulty in swallowing, inflammation of esophagus, gastric ulcer, rectal hemorrhage, loose stools, dysphagia, esophagitis, gastritis, hemorrhoidal hemorrhage, increased GGT, and vomiting.
• Genitourinary System- Urinary tract infection, renal impairment, increased erection, spontaneous penile erection and painful erection or a prolonged erection that persists for more than 4 hours (that can be damaging for penis), and priapism.
• Liver- Abnormal Liver function tests.
• Musculoskeletal System- Muscle ache, myalgia, arthralgia, back pain, pain in extremities, limb pain, joint pain and neck pain.
• Respiratory System -Upper and lower respiratory tract infection, dyspnea, cough, inflammation of bronchus, and difficulty in breathing.
• Hypersensitivity- Exfoliative dermatitis, Stevens-Johnson syndrome, and urticaria.
• Miscellaneous- Influenza, face edema, and pain.

Inform your doctor immediately if you experience any of these side effects. This is not a comprehensive list of all the possible side effects of Megalic tablets (Generic Tadalafil). If you develop any other medical conditions during the course of treatment with Tadalafil tablets, please consult your doctor immediately.

Tadalafil During Pregnancy and Breast-Feeding

Tadalafil has been classified by the US FDA as Pregnancy Category B.
Tadalafil tablets is not ordinarily used in women. During pregnancy, Tadalafil tablets should be used only when clearly necessary. Discuss the risks and benefits of Tadalafil tablets with your doctor. It is unknown if Tadalafil tablets can transmit into breast milk. Discuss the implications with your doctor before breast-feeding.
There are no adequate and well controlled studies of Tadalafil use in pregnant women. Animal reproduction studies in rats and mice revealed no evidence of fetal harm.
Animal reproduction studies showed no evidence of teratogenicity, embryotoxicity, or fetotoxicity when Tadalafil was given to pregnant rats or mice at exposures up to 11 times the maximum recommended human dose (MRHD) of 20 mg/day during organogenesis.
Do not use this medicine without your doctor's consent in case you are pregnant. Stop using this medication and inform your doctor immediately if you become pregnant during treatment.

Buy Tadalafil 10 mg and 20 mg Pills (Megalis Tablets) Online From Only $0.87 per Pill

You can buy Tadalafil pills online from Everest Online Pharmacy at a cheap price. Megalis tablets, manufactured by Macleods, India are supplied in a box of 4 tablets. The 10 mg pills cost only $ 0.87 per unit when you place an order for 300 tablets.

Disclaimer

The above information is provided to the best of our knowledge and in good faith. It is without a warrant of any kind, expressed or implied.

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