Levodopa And Carbidopa Tablets

Levodopa and Carbidopa Tablets (Syndopa) - Product Information

Syndopa tablets, also known as Levodopa and Carbidopa generic, is used for the treatment of Parkinson's disease and symptoms which are related to Parkinson's disease such as muscle stiffness, tremors, spasms, and poor muscle control.
These Parkinson's disease symptoms are known to develop due to low levels of dopamine neurotransmitter in the brain. Parkinson's-like symptoms occur due to swelling in the brain (encephalitis) or nervous system injury from the ingestion of carbon monoxide or intoxication by manganese.
Syndopa tablets contain an antidyskinetic combination of Levodopa and Carbidopa as the active ingredient. Levodopa, which belongs to a class of medications known as central nervous system agents, is converted to dopamine in the brain. Carbidopa, on the other hand, is a decarboxylase inhibitor, which prevents the premature breakdown of Levodopa before it reaches the brain.
In our online pharmacy, Syndopa tablets are available as a combination of Levodopa and Carbidopa in the strength of 100 mg and 10 mg (Syndopa 110), 100 mg and 25 mg (Syndopa 125), and 250 mg and 25 mg (Syndopa 275) respectively.
We also have in stock Donepezil Hydrochloride Tablets (Donecept) which is used effective treatment of dementia, which is characteristic of patients suffering from mild to moderate Alzheimer's disease. Donepezil Hydrochloride tablets are useful to improve the symptoms of dementia such as memory loss, difficulties in thinking and reasoning.

Name of the Drug

Syndopa tablets. Syndopa tablets are also available under different brand names such as Duodopa, LCD, Levopa-C, Neocare, Neocare Plus, Pardopa, Parkimet, Sinemet, Sinemet Plus, Tidomet-CR, Tidomet Forte, Tidomet LS, and Tidomet Plus. Syndopa tablets are also known as Generic Levodopa and Carbidopa tablets.

Manufacturer of Syndopa Tablets

Syndopa tablets, available in our online pharmacy are manufactured by Sun Pharmaceutical Industries Limited, India  
Website: www.sunpharma.com

Active Pharmaceutical Ingredient

The active ingredient present in Syndopa tablets is Levodopa and Carbidopa. Each Syndopa tablet contains a combination of Levodopa and Carbidopa in the strength of 100 mg and 10 mg (Syndopa 110), 100 mg and 25 mg (Syndopa 125), and 250 mg and 25 mg (Syndopa 275) respectively. The inactive ingredients present in Generic Levodopa and Carbidopa pills are hydroxypropyl cellulose, pregelatinized starch, crospovidone, microcrystalline cellulose, magnesium stearate, FD&C Blue #2/lndigo Carmine AL, D&C Yellow #10 Lake.

Syndopa Tablets Indications - What is Levodopa and Carbidopa Used For?

Syndopa tablets, manufactured by Sun Pharmaceuticals Pvt. Ltd. contains an antidyskinetic combination of Levodopa and Carbidopa in the strength of 100 mg and 10 mg, 100 mg and 25 mg, and 250 mg and 25 mg respectively. Syndopa tablets are commonly used as oral therapy for the treatment of Parkinson's disease and Parkinson's-like symptoms such as trembling, body rigidness, difficulty moving. Parkinson's disease is known to develop in patients diagnosed with a low level of dopamine neurotransmitter activity. Levodopa, which belongs to a class of medications known as central nervous system agents, is converted to dopamine in the brain and thus controls the body movement. Carbidopa, on the other hand, is a decarboxylase inhibitor, which prevents the premature breakdown of Levodopa before it reaches the brain so that more Levodopa can cross the blood brain barrier and enter the brain. Levodopa and Carbidopa tablets may be used alone for the treatment of Parkinson's disease or it may be used in combination with other medications.

Levodopa and Carbidopa Dosage - How to Take Syndopa Tablets?

Generic Levodopa and Carbidopa tablets should be administered exactly as suggested by your doctor. Your doctor may recommend a dosage of Syndopa tablets depending on your age, medical requirement, body weight, other medical conditions, and current medications.
Levodopa and Carbidopa tablets should be orally administered on an empty stomach, minimum 1 to 2 hours before meals. Eating a meal with high-protein content may obstruct the absorption of the medication in the system. Syndopa tablets can be taken 3 to 4 times a day, preferably starting with the first dose in the morning. To decrease the risk of side effects of excess dopamine in the brain, your doctor may start your treatment course by recommending a low dosage level and slowly increasing it to the most effective dosage. It may take several weeks to a couple of months after treatment with Levodopa and Carbidopa tablets to observe the full therapeutic effect of Syndopa tablets.
Your doctor may alter the dosage of Syndopa tablets depending on your response to treatment and the severity of the medical condition. Syndopa tablets work effectively if the amount of the Levodopa and Carbidopa is maintained at a constant level in the body. You should be systematic about the daily schedule for the medication such that you take Levodopa and Carbidopa tablets at about the same time every day, to get the maximum benefit of the medication. Continue taking Levodopa and Carbidopa tablets without missing any doses for the recommended treatment period and do not stop the treatment suddenly even if you feel better. Abrupt discontinuation of treatment with Syndopa tablets may result in the development of unpleasant withdrawal symptoms. To avoid this situation, your dosage of Syndopa tablets will have to be gradually reduced.
If you are taking multivitamins and minerals containing iron salts, avoid eating them 2 hours before or after your dosage of Syndopa tablets because iron reduces the levels of Levodopa and Carbidopa in the body. If you have been taking another medication containing Levodopa, do not start the treatment with Syndopa tablets until at least 12 hours after your final dose of Levodopa medications.
Please consult your doctor for exact dosing instructions. Syndopa tablets (Generic Levodopa and Carbidopa tablets) should be administered in the dose prescribed by the doctor and for the duration recommended by the doctor.

Missed Dose

If you miss your regular dose of Levodopa and Carbidopa tablets, take it as soon as you remember. You can continue your regular schedule the next day. If you remember the missed Levodopa and Carbidopa tablets the next day, take your regular dose and skip the missed dose.
Do not take a double dose to compensate the missed dose of Levodopa and Carbidopa tablets.

Levodopa and Carbidopa Mechanism of Action – How Does Syndopa Work?

The symptoms of Parkinson's disease such as muscle stiffness, tremors, spasms, and poor muscle control are known to develop due to low levels of dopamine neurotransmitter in the brain. Syndopa tablets contain an antidyskinetic combination of Levodopa and Carbidopa as the active ingredient. Levodopa, which belongs to a class of medications known as central nervous system agents, is converted to dopamine in the brain and thus controls the body movement. Carbidopa, on the other hand, is a decarboxylase inhibitor, which prevents the premature breakdown of Levodopa before it reaches the brain so that more Levodopa can cross the blood brain barrier and enter the brain.

Storage Instructions for Syndopa Tablets

Store Syndopa tablets at controlled room temperature (20°C to 25°C),protected from heat, moisture, and sunlight. Excursions are permitted from 15°C to 30°C.
Retain the original packing of the medication and do not consume Levodopa and Carbidopa tablets (Syndopa) beyond its expiration date printed on the blister pack. Keep the pack of Generic Levodopa and Carbidopa tablets away from the reach of children and pets. Do not discard Levodopa and Carbidopa tablets along with domestic waste or sewage. Consult your doctor or pharmacist about the correct method of disposal.

Contraindications

Syndopa Tablets Contraindications Syndopa tablets are contraindicated in patients with a known hypersensitivity to Levodopa and Carbidopa or any inactive ingredient present in Syndopa tablets. tablets are contraindicated in patients with a hypersensitivity to or any inactive ingredient present in tablets. are contraindicated in the following cases:

Overdose

Management of acute overdosage with Syndopa tablets (Generic Levodopa and Carbidopa tablets) is the same as management of acute overdosage with levodopa. Pyridoxine is not effective in reversing the actions of Syndopa tablets.
General supportive measures should be employed, along with immediate gastric lavage. Intravenous fluids should be administered judiciously and an adequate airway maintained. Electrocardiographic monitoring should be instituted and the patient carefully observed for the development of arrhythmias; if required, appropriate antiarrhythmic therapy should be given.

Warnings and Precautions to be taken when using Levodopa and Carbidopa Tablets

Medical History
Before beginning the treatment with Syndopa tablets (Generic Levodopa and Carbidopa tablets), discuss your personal and family medical history with your doctor. Inform your doctor if you have a narrow-angle glaucoma, undiagnosed skin growths, skin cancer, or a history of skin cancer, bleeding disorders, breathing problems (e.g., asthma, emphysema), heart or blood vessel problems (e.g., arrhythmias, heart attack, angina), kidney disease, liver disease, mental/mood disorders (e.g., depression, schizophrenia), peptic ulcer, seizure, sleep disorder.
Allergy
Please inform your doctor if you have an allergy or have had an allergic reaction in the past to Levodopa and Carbidopa or any inactive ingredient in Syndopa tablets (Generic Levodopa and Carbidopa tablets). Please tell your doctor if you have any other allergies.
Levodopa and Carbidopa Interactions
Before beginning the oral therapy of Syndopa tablets, please tell your doctor about all your present medications including prescription drugs, over the counter medications, mineral supplements, herbal products, and vitamins. Generic Levodopa and Carbidopa tablets are known to have drug interactions with certain other medications. Please inform your doctor if you are taking other drugs to treat Parkinson's disease (e.g., all levodopa-containing products, benztropine, entacapone), medicine for high blood pressure (e.g., guanethidine, methyldopa, reserpine), antidepressants (e.g., tricyclics such as amitriptyline/nortriptyline), antipsychotics (e.g., chlorpromazine, thioridazine, risperidone), metoclopramide, phenytoin, papaverine, certain sedatives (e.g., benzodiazepines such as chlordiazepoxide/diazepam), tryptophan (e.g., l-tryptophan, oxitriptan). Do not use Levodopa and Carbidopa tablets if you have taken a monoamine oxidase (MAO) inhibitor (eg, phenelzine) within the last 14 days.
Levodopa and Carbidopa Tablets and Alcohol
Avoid or limit the consumption of alcohol during the treatment with Generic Levodopa and Carbidopa tablets (Syndopa tablets) because it may increase the risk of certain side effects such as dizziness, drowsiness, and lightheadedness.
Levodopa and Carbidopa Tablets - Driving and Other Activities
Levodopa and Carbidopa tablets may make you light-headed or impair your vision. Avoid activities such as driving, using machinery, or performing any activity that requires complete vigilance or perfect vision until you are sure about your safety.
Live Vaccinations, Surgery and Regular Medical Tests
If you plan to have live vaccinations, surgery or any dental procedure, inform your doctor, anesthetist, or dentist about your course of Levodopa and Carbidopa tablets. In case of an emergency medical treatment, please inform the practitioner about your course of Levodopa and Carbidopa tablets and the details of your last dose.

Side Effects of Syndopa Tablets

The following side effects have been reported during the course of treatment with Syndopa tablets (Generic Levodopa and Carbidopa tablets):

• Cardiovascular System- chest pain, fast or irregular heartbeat
• Central Nervous System- confusion, drowsiness, headache, sleeping problems, depression, hallucinations, mental or mood changes, severe lightheadedness, fainting, suicidal thoughts, seizures
• ENT- sore throat, changes in vision
• Gastrointestinal System- constipation, diarrhea, dry mouth, nausea, stomach upset, vomiting, blood in vomit, severe abdominal pain
• Genitourinary System- urinary tract infection, black tarry stools
• Musculoskeletal System- muscle pain, unusual stiffness, unusual or painful movements or spasms of the face/eyelids/mouth/tongue/arms/hands/legs
• Hypersensitivity- hives; difficulty breathing; swelling of your face, lips, tongue, throat, hands, feet; tightness in the chest; redness
• General- increased sweating, loss of appetite, change in taste, fever, unusual bruising or bleeding, yellowing of the eyes or skin, trouble breathing

Inform your doctor immediately if you experience any of these side effects. This is not an exhaustive list of all the potential side effects of Syndopa tablets. Please contact your doctor immediately in case you develop any other medical conditions during the course of treatment with Levodopa and Carbidopa tablets.

Levodopa and Carbidopa Tablets During Pregnancy and Breastfeeding

Levodopa and Carbidopa tablets (Syndopa) has been classified by the US FDA as Pregnancy Category C.
No teratogenic effects were observed in a study in mice receiving up to 20 times the maximum recommended human dose of Syndopa. There was a decrease in the number of live pups delivered by rats receiving approximately two times the maximum recommended human dose of Carbidopa and approximately five times the maximum recommended human dose of Levodopa during organogenesis. Levodopa and Carbidopa tablets caused both visceral and skeletal malformations in rabbits at all doses and ratios of Carbidopa/Levodopa tested.
There are no adequate or well-controlled studies in pregnant women. It has been reported from individual cases that Levodopa crosses the human placental barrier, enters the fetus, and is metabolized. Carbidopa concentrations in fetal tissue appeared to be minimal. Use of Levodopa and Carbidopa tablets in women of childbearing potential requires that the anticipated benefits of the drug be weighed against possible hazards to mother and child.
Do not use this medicine without your doctor's consent in case you are pregnant. Stop using this medication and inform your doctor immediately if you become pregnant during treatment.

Buy Levodopa and Carbidopa (Syndopa 110, 125 & 275) Pills Online From Only $0.21 per Pill

You can buy Generic Levodopa and Carbidopa online from Everest Online Pharmacy at a cheap price. Syndopa tablets are available as a combination of Levodopa and Carbidopa in the strength of 100 mg and 10 mg (Syndopa 110), 100 mg and 25 mg (Syndopa 125), and 250 mg and 25 mg (Syndopa 275) pills. They are manufactured by Sun Pharmaceutical Industries Limited, India, and supplied in a blister strip of 10 tablets. The 110 mg tablets cost only $0.21 per unit when you place an order for 360 tablets.

Disclaimer

The above information is provided to the best of our knowledge and in good faith. It is without a warrant of any kind, expressed or implied.

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