Hydrocortisone Tablets

Hisone Tablets (Hydrocortisone Tablets) - Product Information

Hisone (Generic Hydrocortisone Tablets) is commonly used for various inflammatory, autoimmune, hormonal, and other conditions where a corticosteroid may be used, which include the following: Severe allergic conditions, Certain disorders of your skin, hormonal system, digestive tract, blood, nervous system, eyes, kidneys, or lungs, Certain types of cancer (to ease the symptoms),Rheumatic diseases (such as rheumatoid arthritis), which are painful and inflammatory conditions that affect your joints, tendons, ligaments, bones, and muscles as well as reduced adrenal gland function (adrenal insufficiency).
Hisone Tablets are manufactured by Samarth Life Sciences Private Limited, India, in the strengths of 5 mg, 10 mg and 20 mg.
We also have in stock Generic Prednisolone (Omnacortil tablets) which is also used to treat a wide range of health problems including allergies, blood disorders, skin diseases, inflammation, infections and certain cancers and to prevent organ rejection after a transplant.

Name of the Drug

Hisone Tablets.

Manufacturer of Tablets

Samarth Life Sciences Private Limited, India.  
Website: samarthlife.com

Active Pharmaceutical Ingredient

The active pharmaceutical ingredient present in Hisone Tablets is Hydrocortisone. Each Hisone tablet contains 5 mg, 10 mg or 20 mg of Hydrocortisone.

Uses of Hisone Tablets (Generic Hydrocortisone Tablets)

Hisone Tablets (Generic Hydrocortisone Tablets) provides relief for inflamed areas of the body. This medicine is used to treat a number of different conditions, such as inflammation (swelling), severe allergies, adrenal problems, arthritis, blood or bone marrow problems, eye or vision problems, lung or breathing problems (eg, asthma), lupus, skin conditions, and ulcerative colitis.
Hydrocortisone is a corticosteroid (cortisone-like medicine or steroid). It works on the immune system to help relieve swelling, redness, itching, and allergic reactions.
Hisone Tablets are indicated in the following conditions. 1. Endocrine Disorders:
Primary or secondary adrenocortical insufficiency (hydrocortisone or cortisone is the first choice; synthetic analogs may be used in conjunction with mineralocorticoids where applicable; in infancy mineralocorticoid supplementation is of particular importance)
Congenital adrenal hyperplasia
Non suppurative thyroiditis
Hypercalcemia associated with cancer
2. Rheumatic Disorders :
As adjunctive therapy for short-term administration (to tide the patient over an acute episode or exacerbation) in:
Psoriatic arthritis
Rheumatoid arthritis, including juvenile rheumatoid arthritis (selected cases may require low-dose maintenance therapy)
Ankylosing spondylitis
Acute and subacute bursitis
Acute nonspecific tenosynovitis
Acute gouty arthritis
Post-traumatic osteoarthritis
Synovitis of osteoarthritis
Epicondylitis
3. Collagen Diseases :
During an exacerbation or as maintenance therapy in selected cases of: Systemic lupus erythematosus Systemic dermatomyositis (polymyositis) Acute rheumatic carditis
4. Dermatologic Diseases :
Pemphigus Bullous dermatitis herpetiformis Severe erythema multiforme (Stevens-Johnson syndrome) Exfoliative dermatitis Mycosis fungoides Severe psoriasis Severe seborrheic dermatitis
5. Allergic States :
Control of severe or incapacitating allergic conditions intractable to adequate trials of conventional treatment:
Seasonal or perennial allergic rhinitis
Serum sickness
Bronchial asthma
Contact dermatitis
Atopic dermatitis
Drug hypersensitivity reactions
6. Ophthalmic Diseases :
Severe acute and chronic allergic and inflammatory processes involving the eye and its adnexa such as:
Allergic conjunctivitis
Keratitis
Allergic corneal marginal ulcers
Herpes zoster ophthalmicus
Iritis and iridocyclitis
Chorioretinitis
Anterior segment inflammation
Diffuse posterior uveitis and choroiditis
Optic neuritis
Sympathetic ophthalmia
7. Respiratory Diseases :

Symptomatic sarcoidosis
Loeffler’s syndrome not manageable by other means
Berylliosis
Fulminating or disseminated pulmonary tuberculosis when used concurrently with appropriate antituberculous chemotherapy
Aspiration pneumonitis
8. Hematologic Disorders :
Idiopathic thrombocytopenic purpura in adults
Secondary thrombocytopenia in adults
Acquired (autoimmune) hemolytic anemia
Erythroblastopenia (RBC anemia)
Congenital (erythroid) hypoplastic anemia
9. Neoplastic Diseases :
For palliative management of:
Leukemias and lymphomas in adults
Acute leukemia of childhood
10. Edematous States :
To induce a diuresis or remission of proteinuria in the nephrotic syndrome, without uremia, of the idiopathic type or that due to lupus erythematosus.
11. Gastrointestinal Diseases :
To tide the patient over a critical period of the disease in:
Ulcerative colitis
Regional enteritis
12. Nervous System :
Acute exacerbations of multiple sclerosis
13. Miscellaneous :
Tuberculous meningitis with subarachnoid block or impending block when used concurrently with appropriate antituberculous chemotherapy
Trichinosis with neurologic or myocardial involvement

Hisone Tablets (Generic Hydrocortisone Tablets) - Dosage

Generic Hydrocortisone tablets should be administered exactly as suggested by your doctor. Your doctor may recommend a dosage of Hisone tablets depending on your age, medical requirement, body weight, other medical conditions, and current medications.
The initial dosage of Tablets may vary from 20 mg to 240 mg of Hydrocortisone per day depending on the specific disease entity being treated. In situations of less severity lower doses will generally suffice while in selected patients higher initial doses may be required. The initial dosage should be maintained or adjusted until a satisfactory response is noted. If after a reasonable period of time there is a lack of satisfactory clinical response, Hisone should be discontinued and the patient transferred to other appropriate therapy.
Hisone tablets work effectively if the amount of Hydrocortisone is maintained at a constant level in the body. You should be systematic about the daily schedule for the medication such that you take tablets at about the same time every day, to get the maximum benefit of the medication. Continue taking Hydrocortisone tablets without missing any doses for the recommended treatment period and do not stop the treatment suddenly even if you feel better.

Please consult your doctor for exact dosing instructions. Hisone tablets (Generic Hydrocortisone tablets) should be administered in the dose prescribed by the doctor and for the duration recommended by the doctor.

Missed Dose

If you forget to take your regular Hisone tablet dose on time, take it whenever you remember.
If you remember the next day, skip the missed dose and take your scheduled dose. Do not take a double dose to compensate the missed dose.

Hydrocortisone Tablets - Mechanism of Action

Naturally occurring glucocorticoids (Hydrocortisone and Cortisone), which also have salt-retaining properties, are used as replacement therapy in adrenocortical deficiency states. Their synthetic analogs are primarily used for their potent anti-inflammatory effects in disorders of many organ systems.
Glucocorticoids cause profound and varied metabolic effects. In addition, they modify the body’s immune responses to diverse stimuli.

Storage Instructions for Hisone Tablets (Hydrocortisone Tablets)

Store at controlled room temperature (20°C to 25°C),protected from heat, moisture, and sunlight. Excursions are permitted from 15°C to 30°C.
Retain the original packing of the medication and do not consume past its expiration date printed on the blister pack. Keep the pack of away from the reach of children and pets. Do not dispose along with domestic waste or sewage. Consult your doctor or pharmacist about the correct method of disposal.

Contraindications

Hisone tablets are contraindicated in patients with a hypersensitivity to Hydrocortisone or any inactive ingredient present in tablets. Hisone are contraindicated in the following cases:
Contraindicated in infections including systemic infections where anti-infective therapy has not been started.
High doses of corticosteroids impair the immune response to vaccines. Therefore the concomitant administration of live vaccines with corticosteroids should be avoided.

Overdose

Overdosage may cause nausea and vomiting, sodium and water retention, hyperglycemia and occasional gastrointestinal bleeding. Management Treatment need only be symptomatic although Cimetidine (200-400 mg by slow intravenous injection every 6 hours) or Ranitidine (50 mg by slow intravenous injection every 6 hours) may be administered to prevent gastrointestinal bleeding.

Warnings and Precautions

Adrenal suppression
Adrenal cortical atrophy develops during prolonged therapy and may persist for years after stopping treatment. Withdrawal of corticosteroids after prolonged therapy must therefore always be gradual to avoid acute adrenal insufficiency, being tapered off over weeks or months according to the dose and duration of treatment. During prolonged therapy, any intercurrent illness, trauma or surgical procedure will require a temporary increase in dosage. If corticosteroids have been stopped following prolonged therapy, they may need to be temporarily re-introduced.
Anti-inflammatory / immunosuppressive effects and infection


Suppression of inflammatory response and immune function increases the susceptibility to infections and their severity. The clinical presentation can often be atypical and serious infections such as septicaemia and tuberculosis may be masked and may reach an advanced stage before being recognized. New infections may appear during their use.
Paediatric population:
Corticosteroids cause growth retardation in infancy, childhood and adolescence; this may be irreversible. Treatment should be limited to the minimum dosage for the shortest possible time.
Withdrawal symptoms:
In patients who have received more than physiological doses of systemic corticosteroids (approximately 40 mg cortisone or equivalent) for greater than three weeks, withdrawal should not be abrupt. How dose reduction should be carried out depends largely on whether the disease is likely to relapse as the dose of systemic corticosteroids is reduced. Clinical assessment of disease activity may be needed during withdrawal. If the disease is unlikely to relapse on withdrawal of systemic corticosteroids but there is uncertainty about hypothalamic-pituitary adrenal (HPA) suppression, the dose of systemic corticosteroid may be reduced rapidly to physiological doses.
Visual disturbance
Visual disturbance may be reported with systemic and topical corticosteroid use. If a patient presents with symptoms such as blurred vision or other visual disturbances, the patient should be considered for referral to an ophthalmologist for evaluation of possible causes which may include cataract, glaucoma or rare diseases such as central serous chorioretinopathy (CSCR) which have been reported after use of systemic and topical corticosteroids.



 

Effects On Ability To Drive And Use Machines

Hydrocortisone has minor influence on the ability to drive and use machines. Fatigue and episodes of short lasting vertigo have been reported.
Untreated and poorly replaced adrenal insufficiency may affect the ability to drive and use machines.

Side Effects of

Like all medicines, Hisone tablets can cause side effects, although not everybody gets them. People taking steroids to replace similar naturally occurring hormones should be less likely to get side effects than people taking steroids for other illnesses.
Fluid and Electrolyte Disturbances :
Sodium retention, Fluid retention, Congestive heart failure in susceptible patients, Potassium loss, Hypokalemic alkalosis and Hypertension
Musculoskeletal :
Muscle weakness, Steroid myopathy, Loss of muscle mass, Osteoporosis , Vertebral compression fractures, Aseptic necrosis of femoral and humeral heads, Pathologic fracture of long bones and Tendon rupture
Gastrointestinal :
Peptic ulcer with possible perforation and hemorrhage, Perforation of the small and large bowel, particularly in patients with inflammatory bowel disease, Pancreatitis, Abdominal distention and Ulcerative esophagitis
Dermatologic :
Impaired wound healing, Thin fragile skin, Petechiae and ecchymoses , Erythema , Increased sweating, May suppress reactions to skin tests, Other cutaneous reactions, such as allergic dermatitis, urticaria, angioneurotic edema
Neurologic :
Convulsions, Increased intracranial pressure with papilledema (pseudotumor cerbri) usually after treatment, Vertigo, Headache and Psychic disturbances
Endocrine :
Menstrual irregularities, Development of cushingoid state, Suppression of growth in children Secondary adrenocortical and pituitary unresponsiveness, particularly in times of stress, as in trauma, surgery, or illness Decreased carbohydrate tolerance, Manifestations of latent diabetes mellitus, Increased requirements for insulin or oral hypoglycemic agents in diabetics and Hirsutism
Ophthalmic :
Posterior subcapsular cataracts, Increased intraocular pressure, Glaucoma and Exophthalmos
Metabolic:
Negative nitrogen balance due to protein catabolism
Cardiovascular :
Myocardial rupture following recent myocardial infarction
Other :

Hypersensitivity, Thromboembolism , Weight gain , Increased appetite, Nausea and Malaise

Hisone Tablets (Hydrocortisone Tablets)

During Pregnancy

Hydrocortisone has been classified by the US FDA as Pregnancy Category C.

Since adequate human reproduction studies have not been done with corticosteroids, the use of these drugs in pregnancy, nursing mothers or women of childbearing potential requires that the possible benefits of the drug be weighed against the potential hazards to the mother and embryo or fetus.
Infants born of mothers who have received substantial doses of corticosteroids during pregnancy, should be carefully observed for signs of hypoadrenalism.
Administration of corticosteroids to pregnant animals can cause abnormalities of foetal development including cleft palate, intra-uterine growth retardation and effects on brain growth and development. There is no evidence that corticosteroids result in an increased incidence of congenital abnormalities, such as cleft palate / lip in man.
However, when administered for prolonged periods or repeatedly during pregnancy, corticosteroids may increase the risk of intra-uterine growth retardation Do not use this medicine without your doctor's consent in case you are pregnant.
Stop using this medication and inform your doctor immediately if you become pregnant during treatment.

Nursing Considerations

Corticosteroids are excreted in breast milk, although no data are available for hydrocortisone. Infants of mothers taking high doses of systemic corticosteroids for prolonged periods may have a degree of adrenal suppression. Mothers taking pharmacological doses of corticosteroids should be advised not to breast-feed. Any maternal treatment should be carefully documented in the infant's medical records to assist in follow up.
Do not use this medication without telling your doctor if you are breast-feeding a baby.

Buy Hisone Pills (Hydrocortisone 5 mg 10 mg and 20 mg Tablets) Online From Only $0.26 per Pill

You can buy Hydrocortisone tablets online from Everest Online Pharmacy at a cheap price. Hisone 5 mg, 10 mg and 20 mg pills, manufactured by Samarth Life Sciences Private Limited, India, are supplied in a blister strip of 10 tablets. The 5 mg tablets cost only $0.26 per unit when you place an order for 360 tablets.

Disclaimer

The above information is provided to the best of our knowledge and in good faith. It is without a warrant of any kind, expressed or implied.

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