Generic Anastrozole Tablets

Anazole (Generic Anastrozole 1 mg Tablets) - Product Information

Anazole (Generic Anastrozole 1 mg Tablets) is used for the treatment of hormone receptor-positive advanced breast cancer in postmenopausal women.
It is also used for adjuvant treatment of hormone receptor-positive early invasive breast cancer in postmenopausal women and adjuvant treatment of hormone receptor-positive early invasive breast cancer in postmenopausal women who have received 2 to 3 years adjuvant Tamoxifen.
Anazole tablets are manufactured by Alpha Pharma Healthcare Private limited, India, in the strengths of 1 mg of Anastrozole.
We also have in stock Altamofen Tablets (Generic Tamoxifen Citrate) which are prescribed as oral therapy in women as well as men who have developed breast tumors which are dependent on estrogen for their growth and survival in the body.

Name of the Drug

Anazole tablets.

Manufacturer of Anazole Tablets

Alpha Pharma Healthcare Private limited, India.  
Website: www.alpha-pharma.com

Active Pharmaceutical Ingredient

The active ingredient present in Anazole tablets is Anastrozole. Each Anazole tablet contains 1 mg of Anastrozole.

Uses of Anastrozole Tablets (Anazole 1 mg Tablets)

Anazole (Generic Anastrozole 1 mg Tablets) is a prescription-only aromatase inhibitor used to treat hormone receptor-positive early and advanced breast cancer in postmenopausal women. It is also used for first-line treatment of hormone receptor-positive or hormone receptor-unknown advanced or metastatic (cancer that has spread) breast cancer.
Anastrozole is also used to treat advanced breast cancer that has grown or spread after Tamoxifen treatment. This medicine is used only in women who have already stopped menstruating (postmenopausal).
Many breast cancer tumors grow in response to estrogen. This medicine interferes with the production of estrogen in the body. As a result, the amount of estrogen that the tumor is exposed to is reduced, limiting the growth of the tumor.
Due to the fact that Generic Arimidex tablets act as anti-estrogens, Anazole is used offlabel by male bodybuilders as part of their Post Cycle Therapy (PCT).

Anazole 1 mg Tablets (Generic Anastrozole Tablets) - Dosage

Generic Anastrozole tablets should be administered exactly as suggested by your doctor. Your doctor may recommend a dosage of Anazole tablets depending on your age, medical requirement, body weight, other medical conditions, and current medications.
The recommended dose of Anastrozole for adults including the elderly is one 1 mg tablet once a day.
For postmenopausal women with hormone receptor-positive early invasive breast cancer, the recommended duration of adjuvant endocrine treatment is 5 years.
Anazole tablets work effectively if the amount of Anastrozole is maintained at a constant level in the body. You should be systematic about the daily schedule for the medication such that you take tablets at about the same time every day, to get the maximum benefit of the medication. Continue taking Anastrozole tablets without missing any doses for the recommended treatment period and do not stop the treatment suddenly even if you feel better.

Please consult your doctor for exact dosing instructions. Anazole tablets (Generic Anastrozole tablets) should be administered in the dose prescribed by the doctor and for the duration recommended by the doctor.

Missed Dose

If you forget to take your regular tablet dose on time, take it whenever you remember, as long as it is taken at least 12 hours before the next dose is due.
A missed dose should not be taken within 12 hours of the next dose.

Anastrozole Mechanism of Action – How do Anazole Tablets Work?

Many breast cancers have estrogen receptors and growth of these tumours can be stimulated by estrogens. In postmenopausal women, the principal source of circulating estrogen (primarily Estrone) is conversion of adrenally-generated Androstenedione to Estrone by aromatase in peripheral tissues, such as adipose tissue, with further conversion of Estrone to Estradiol. Many breast cancers also contain aromatase; the importance of tumour-generated estrogens is uncertain.
Treatment of breast cancer has included efforts to decrease estrogen levels by ovariectomy pre-menopausally and by use of anti-estrogens and progestational agents both pre- and post-menopausally, and these interventions lead to decreased tumour mass or delayed progression of tumour growth in some women.
Anazole (Generic Anastrozole Tablets) is a potent and selective non-steroidal aromatase inhibitor. It significantly lowers serum estradiol concentrations and has no detectable effect on formation of adrenal corticosteroids or Aldosterone.

Storage Instructions for Anazole Tablets (Generic Anastrozole Tablets)

Store Anazole tablets at controlled room temperature (20°C to 25°C),protected from heat, moisture, and sunlight. Excursions are permitted from 15°C to 30°C.
Retain the original packing of the medication and do not consume Anazole tablets past its expiration date printed on the blister pack. Keep the pack of Generic Anastrozole tablets away from the reach of children and pets. Do not dispose along with domestic waste or sewage. Consult your doctor or pharmacist about the correct method of disposal.

Contraindications

Anazole tablets are contraindicated in patients with a hypersensitivity to Anastrozole or any inactive ingredient present in Anazole tablets. Observed reactions include anaphylaxis, angioedema, and urticaria. Anazole tablets are contraindicated in the following cases:
Pregnant or lactating women.

Overdose

There is limited clinical experience of accidental overdosage. Acute toxicity was seen in animals at a dose greater than 45 mg/kg (equivalent to 2.7 g). Clinical trials have been conducted with various dosages of Anazole (Anastrozole), up to 60 mg in a single dose given to healthy male volunteers and up to 10 mg daily given to postmenopausal women with advanced breast cancer; these dosages were well tolerated. A single dose of Anastrozole that results in life-threatening symptoms has not been established. There is no specific antidote to overdosage and treatment must be symptomatic. In the management of an overdose, consideration should be given to the possibility that multiple agents may have been taken. Vomiting may be induced if the patient is alert. Dialysis may be helpful because Anastrozole is not highly protein bound. General supportive care, including frequent monitoring of vital signs and close observation of the patient, is indicated.

Warnings and Precautions

General
Anastrozole should not be used in premenopausal women. The menopause should be defined biochemically (luteinizing-hormone [LH], follicle stimulating hormone [FSH], and/or estradiol levels) in any patient where there is doubt about menopausal status. There are no data to support the use of Anastrozole with LHRH analogues. Potential risk/benefit should be carefully assessed in patients with severe hepatic and severe renal impairment.Potential risk/benefit should be carefully assessed in patients with osteoporosis or risk factors for osteoporosis.
Ischemic Cardiovascular Events:
In women with pre-existing ischemic heart disease, an increased incidence of ischemic cardiovascular events was observed with Anastrozole tablets in the ATAC trial (17% of patients on Anastrozole tablets and 10% of patients on tamoxifen). Consider risk and benefits of Anastrozole tablets therapy in patients with pre-existing ischemic heart disease.
Bone Effects
Results from the ATAC trial bone substudy at 12 and 24 months demonstrated that patients receiving Anastrozole tablets had a mean decrease in both lumbar spine and total hip bone mineral density (BMD) compared to baseline. Patients receiving tamoxifen had a mean increase in both lumbar spine and total hip BMD compared to baseline. Consider bone mineral density monitoring in patients treated with Anastrozole tablets.
Cholesterol
During the ATAC trial, more patients receiving Anastrozole tablets were reported to have elevated serum cholesterol compared to patients receiving tamoxifen (9% versus 3.5%, respectively)
Embryo-Fetal Toxicity
Based on findings from animal studies and its mechanism of action, Anastrozole tablets can cause fetal harm when administered to a pregnant woman. Anastrozole caused embryo-fetal toxicities in rats at maternal exposure that were 9 times the human clinical exposure, based on area under the curve (AUC). Advise pregnant women and females of reproductive potential of the potential risk to a fetus.
Driving and Operating Machinery
Anastrozole is unlikely to impair the ability of patients to drive and operate machinery. However, asthenia and somnolence have been reported with the use of Anastrozole and caution should be observed when driving or operating machinery while such symptoms persist.
Arthralgia/Arthritis:
The use of Aromatase Inhibitors, including Anastrozole, may cause arthralgia/arthritis, which may impact on treatment compliance and quality of life.

Side Effects of Anazole Tablets (Generic Anastrozole Tablets)

Common side effects occurring with an incidence of 10% or more in women taking Anastrozole (Anazole Tablets) included: hot flashes, asthenia, arthritis, pain, arthralgia, hypertension, depression, nausea and vomiting, rash, osteoporosis, fractures, back pain, insomnia, headache, bone pain, peripheral edema, increased cough, dyspnea, pharyngitis and lymphedema.

Anastrozole Tablets (Anazole 1 mg) During Pregnancy

Anastrozole (Anazole 1 mg Tablets) has been classified by the US FDA as Pregnancy Category X. Anazole is contraindicated in pregnant women.
The extent of exposure in pregnancy to Anastrozole during clinical trials and postmarketing is very limited to individual cases only. If a patient becomes pregnant while receiving this medicine, the patient should be apprised of the potential hazard to the fetus or potential risk for loss of the pregnancy.
Do not use this medicine without your doctor's consent in case you are pregnant. Stop using this medication and inform your doctor immediately if you become pregnant during treatment.

Nursing Considerations

Anastrozole Tablets (Anazole 1 mg) is contraindicated in lactating women.
Do not use this medication without telling your doctor if you are breast-feeding a baby.

Buy Generic Anastrozole 1 mg Pills Online From Only $0.78 per Pill

You can buy Generic Anastrozole online from Everest Online Pharmacy at a cheap price. Anazole 1 mg pills, manufactured by Alpha Pharma Healthcare Private limited, India, are supplied in a box with 30 tablets. The 1 mg tablets cost only $0.78 per unit when you place an order for 720 tablets.

Disclaimer

The above information is provided to the best of our knowledge and in good faith. It is without a warrant of any kind, expressed or implied.

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