Cyclosporine Ophthalmic Solution

Cyclomune Eye Drops (Cyclosporine 0.05% and 0.1% Ophthalmic Solution) - Product Information

Cyclomune Eye Drops (Cyclosporine Ophthalmic Solution) are used to increase tear production in patients who have a certain eye condition (eg, keratoconjunctivitis sicca). It is also used to treat vernal keratoconjunctivitis (allergic eye condition) and signs and symptoms of dry eye disease.
Cyclomune Eye Drops manufactured by Sun Pharmaceutical Industries Limited, India, are available in the strengths of 0.05% and 0.1% of Cyclosporine.
We also have in stock Careprost ophthalmic solution (Bimatoprost eye drops) which is used to treat certain diseases of the eye like open-angle glaucoma and ocular (eye) hypertension which occurs in many people as they grow older.

Name of the Drug

Cyclomune Eye Drops. This medicine is also known as Generic Cyclosporine Eye Drops.

Manufacturer of Cyclomune Eye Drops

Sun Pharmaceutical Industries Limited, India  
Website: sunpharma.com

Active Pharmaceutical Ingredient

The active ingredient present in Cyclomune Eye Drops is Cyclosporine. Cyclomune Ophthalmic emulsion contains 0.5 mg/mL or 1 mg/mL of Cyclosporine.

Uses of Cyclomune Ophthalmic Solution (Cyclosporine Eye Drops)

Cyclomune Ophthalmic Solution (Cyclosporine Eye Drops) 0.05% and 0.1% is a calcineurin inhibitor immunosuppressant used to increase tear production in patients whose tear production is presumed to be suppressed due to ocular inflammation associated with keratoconjunctivitis sicca. Increased tear production was not seen in patients currently taking topical anti-inflammatory drugs or using punctal plugs.

Cyclomune Eye Drops (Cyclosporine 0.05% and 0.1% Ophthalmic Solution) - Dosage

Cyclomune Eye Drops should be administered exactly as suggested by your doctor. Your doctor may recommend a dosage of Cyclomune Eye Drops depending on your age, medical requirement, body weight, other medical conditions, and current medications.
Instill one drop of Cyclomune ophthalmic solution twice a day in each eye approximately 12 hours apart.
Cyclomune Eye Drops work effectively if the amount of Cyclosporine is maintained at a constant level in the body. You should be systematic about the daily schedule for the medication such that you use Cyclosporine Ophthalmic Solution at about the same time every day, to get the maximum benefit of the medication. Continue using Cyclosporine Ophthalmic Solution without missing any doses for the recommended treatment period and do not stop the treatment suddenly even if you feel better.

Please consult your doctor for exact dosing instructions. Cyclomune Eye Drops (Generic Cyclosporine 0.05% and 0.1% Ophthalmic Solution) should be administered in the dose prescribed by the doctor and for the duration recommended by the doctor.

Missed Dose

If you forget to administer your regular Cyclomune Eye Drops dose on time, use it whenever you remember.
However, if it is almost time for the next dose, the missed dose should be skipped, and the regular dosing schedule resumed. Doses should not be doubled. The dose should not exceed two drops in the affected eye(s) daily.

Mechanism of Action

Cyclosporine is an immunosuppressive agent when administered systemically.
In patients whose tear production is presumed to be suppressed due to ocular inflammation associated with keratoconjunctivitis sicca, cyclosporine emulsion is thought to act as a partial immunomodulator. The exact mechanism of action is not known.

Storage Instructions for Cyclomune Eye Drops (Cyclosporine 0.05% and 0.1% Ophthalmic Solution)

Store Cyclomune Eye Drops at controlled room temperature (20°C to 25°C),protected from heat, moisture, and sunlight. Excursions are permitted from 15°C to 30°C.
Retain the original packing of the medication and do not use past its expiration date printed on the blister pack. Keep the pack of Cyclosporine Eye Drops away from the reach of children and pets. Do not dispose Cyclomune Eye Drops along with domestic waste or sewage. Consult your doctor or pharmacist about the correct method of disposal.

Contraindications

Cyclomune Eye Drops are contraindicated in patients with a hypersensitivity to Cyclosporine or any inactive ingredient present in Cyclomune Eye Drops.

Overdose

Due to low systemic concentrations of Cyclosporine after topical treatment with the ophthalmic emulsion, the likelihood of systemic intoxication from topical overdose is remote.

Warnings and Precautions

Potential For Eye Injury And Contamination:
To avoid the potential for eye injury and contamination, advise patients not to touch the vial tip to the eye or other surfaces
Use with Contact Lenses:
Cyclosporine ophthalmic emulsion should not be administered while wearing contact lenses. Patients with decreased tear production typically should not wear contact lenses. If contact lenses are worn, they should be removed prior to the administration of the emulsion. Lenses may be reinserted 15 minutes following administration of cyclosporine ophthalmic emulsion.
Immune
There is the potential to experience hypersensitivity to Cyclomune Eye Drops. Reactions of severe angioedema, face swelling, tongue swelling, pharyngeal edema, dyspnea and urticaria have been reported with the use of Cyclosporine 0.05% and 0.1% Eye Drops.
Driving and Operating Machinery
Cyclomune Eye Drops may cause transient blurred vision due to its emulsion formulation. If patients experience blurred vision, they should be advised not to drive or operate machinery until vision has cleared.
Ophthalmologic
Cyclomune Eye Drops has not been studied in patients with a history of herpes keratitis, end stage lacrimal gland disease, keratoconjunctivitis sicca (KCS) secondary to the destruction of conjunctival goblet cells such as occurs with Vitamin A deficiency, or scarring, such as occurs with cicatricial pemphigoid, alkali burns, Stevens Johnson syndrome, trachoma, or irradiation .

Side Effects of Cyclosporine 0.05% and 0.1% Ophthalmic Solution (Cyclomune Eye Drops)

During clinical trials the most common side effect following the use of Cyclosporine 0.05% and 0.1% Ophthalmic Solution was ocular burning (17%). Other reactions reported in 1% to 5% of patients included conjunctival hyperemia, discharge, epiphora, eye pain, foreign body sensation, pruritus, stinging, and visual disturbance (most often blurring).
The following adverse reactions have been identified during post approval use of Cyclomune Eye Drops (Cyclosporine 0.05% and 0.1% Ophthalmic Solution). Because these reactions are reported voluntarily from a population of uncertain size, it is not always possible to reliably estimate their frequency or establish a causal relationship to drug exposure.
Reported reactions have included: hypersensitivity (including eye swelling, urticaria, rare cases of severe angioedema, face swelling, tongue swelling, pharyngeal edema and dyspnea); and superficial injury of the eye (from the vial tip touching the eye during administration).

Cyclosporine Ophthalmic Solution (Cyclomune 0.05% and 0.1% Eye Drops) During Pregnancy

has been classified by the US FDA as Pregnancy Category C.
No evidence of embryofetal toxicity was observed in rats or rabbits receiving cyclosporine at oral doses up to 17 mg/kg/day or 30 mg/kg/day, respectively, during organogenesis. These doses in rats and rabbits are approximately 3,000 and 10,000 times greater (normalized to body surface area), respectively, than the daily human dose. There are no adequate and well-controlled studies of Cyclosporine Eye Drops in pregnant women. Cyclomune Eye Drops should be administered to a pregnant woman only if clearly needed.
Do not use this medicine without your doctor's consent in case you are pregnant. Stop using this medication and inform your doctor immediately if you become pregnant during treatment.

Cyclosporine Eye Drops - Nursing Considerations

Cyclosporine is known to be excreted in human milk following systemic administration but excretion in human milk after topical treatment has not been investigated. Although blood concentrations are undetectable after topical administration of Cyclomune Eye Drops, caution should be exercised when Cyclomune Eye Drops is administered to a nursing woman
Do not use this medication without telling your doctor if you are breast-feeding a baby.

Buy Cyclosporine 0.05% and 0.1% Ophthalmic Solution (Cyclomune Eye Drops) Online From Only $17.33 per 3ml Bottle

You can buy Cyclosporine 0.05% and 0.1% Eye Drops online from Everest Online Pharmacy at a cheap price. Cyclomune 0.05% and 0.1% Eye Drops, manufactured by Sun Pharmaceutical Industries Limited, India, are supplied in a bottle. Cyclomune 3 ml bottle in 0.05% strength costs only $17.33 per unit when you place an order for 15 bottles.

Disclaimer

The above information is provided to the best of our knowledge and in good faith. It is without a warrant of any kind, expressed or implied.

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